CCTC Transplant pharmacology (2025)
COMPLETE EXAM SET (QUESTIONS AND
VERIFIED ANSWERS) FREQUENTLY MOST
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Cyclosporine or Sandimmune (Neoral, Gengraf) &
Calcineurin inhibitors
Tacrolimus or hecoria (Prograf)
MOA of Tacrolimus binds to fkbp12 to inhibit interleukin 2 production &
(Prograf) release. Which inhibits cytotoxic T cells.
Binds to cyclophylin to inhibit interleukin 2
MOA of Cyclosporine
production & release. Which inhibits cytotoxic T
(Neoral, Gengraf)
cells.
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, 3/7/25, 8:38 AM CCTC Transplant pharmacology (2025) COMPLETE EXAM SET (QUESTIONS AND VERIFIED ANSWERS) FREQUENTLY MO…
Neurotoxicity (HA, tremors, anxiety, confusion,
sleep disturbance)
Nephrotoxicity
Diarrhea
HTN
side effects of tacrolimus
Hyperkalemia
Hyperglycemia
Hypomagnesemia
HUS
Hypophosphatemia.
tacrolimus & Sirolimus
cyclosporine are NSAID'S
synergistic with which
meds?
how is tacrolimus & Through cytochrome p450 3A4 enzyme pathway in
Sirolimus metabolized? liver.
How many hours is 11-12 hour trough level.
tacrolimus &
cyclosporine troughs?
Decreased by food, especially fatty foods.
absorption of tacrolimus
Best absorbed on empty stomach.
& sirolimus
If taken with food, always take with food.
Macrolide ABX(erythromycin & clarithromycin).
Diltiazem
Meds that raise
verapamil
tacrolimus &
high dose steroids
cyclosporine & Sirolimus
azole antifungals
trough levels
grapefruit (squirt & fresca)
sirolimus
Anti-convulsants (Dilantin, Phenobarbital,
Meds that lower Carbazepine)
tacrolimus cyclosporine Rifampin
& Sirolimus trough levels Caspofungin
St John's wort.
0.2 mg/kg/day divided into 2 doses.
tacrolimus dosage
IV form highly Nephrotoxic.
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