Carbon monoxide
Injures cells by reducing oxygen level on hemoglobin
Malignant neoplasms
Epithelial origin known as carcinomas
Staging procedure
Determines extent of tumor spread
Proto-oncogenes
Normal cellular genes promoting growth
Familial retinoblastoma
Involves transmission of mutant tumor-suppressor gene
Necrotic brain tissue
Produces liquefactive necrosis
Aging effect
Decreased functional reserve on body systems
Preneoplastic change
Dysplasia, considered cellular
Hypermetabolic state
Leads to cachexia due to tumor necrosis factor
Paraneoplastic syndromes
Involve excessive substance production in cancer
Tumor-suppressor gene defect
Most common in cancer cells is P53
Intracellular accumulations
Indicative of injury due to faulty metabolism
Retroviruses
Associated with human cancers like Burkitt lymphoma
Breast cancer gene
Causes earlier onset of breast cancer in women
Lung cancer survival rate
, Approximately 15% survival rate
Nutrition and cellular health
Deficient uptake by one cell type may lead to excess delivery to others
Cancer grading
Based on cell differentiation
Metaplasia
Replacement of one differentiated cell type with another
Differentiated cancer cells
Less tissue-specific are more likely aggressive
Chemotherapy after surgery
Kills rapidly dividing cells
Apoptosis
Results in cellular death
Alarm stage substances
Produced for energy and repair
Excessive cortisol effects
Include immune suppression
Selye's stress phases
Include alarm, resistance, and exhaustion
Extreme cold cell injury
Causes harm except decreased blood viscosity
Subclinical stage
Patient functions normally with established disease processes
Obese teen prescription
Example of secondary prevention with diet and exercise
Insulin stress response
Not normally secreted in response to stress
Heart attack medication
Example of tertiary prevention for cholesterol management
Organ hypertrophy
Increase in size and function due to increased workload