z z
THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND CHILDREN
Z Z Z Z Z Z Z Z
8th Edition
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Kathryn L. McCance, Sue E. Huether
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, z 2
Contents
Chapterz01:zCellularzBiology........................................................................................................................... 4
Chapterz02:zAlteredzCellularzandzTissuezBiology:zEnvironmentalzAgents ..................................................... 18
Chapterz03:zThezCellularzEnvironment:zFluidszandzElectrolytes,zAcidszandzBases ......................................... 31
Chapterz04:zGeneszandzGeneticzDiseases ..................................................................................................... 44
Chapterz05:zGenes,zEnvironment-Lifestyle,zandzCommonzDiseases............................................................. 55
Chapterz06:zEpigeneticszandzDisease ........................................................................................................... 63
Chapterz07:zInnatezImmunity:zInflammationzandzWoundzHealing ............................................................... 68
Chapterz08:zAdaptivezImmunity ................................................................................................................... 83
Chapterz09:zAlterationszinzImmunityzandzInflammation............................................................................... 95
Chapterz10:zInfection ................................................................................................................................. 108
Chapterz11:zStresszandzDisease .................................................................................................................. 117
Chapterz12:zCancerzBiology ........................................................................................................................ 124
Chapterz13:zCancerzEpidemiology .............................................................................................................. 137
Chapterz14:zCancerzinzChildren .................................................................................................................. 143
Chapterz15:zStructurezandzFunctionzofzthezNeurologiczSystem .................................................................. 148
Chapterz16:zPain,zTemperaturezRegulation,zSleep,zandzSensoryzFunction.................................................. 159
Chapterz17:zAlterationszinzCognitivezSystems,zCerebralzHemodynamics,zandzMotorzFunction .................. 174
Chapterz18:zDisorderszofzthezCentralzandzPeripheralzNervouszSystemszandzthezNeuromuscularzJunction
.................................................................................................................................................................188
Chapterz19:zNeurobiologyzofzSchizophrenia,zMoodzDisorders,zandzAnxietyzDisorders............................... 199
Chapterz20:zAlterationszofzNeurologiczFunctionzinzChildren ....................................................................... 206
Chapterz21:zMechanismszofzHormonalzRegulation..................................................................................... 213
Chapterz22:zAlterationszofzHormonalzRegulation ....................................................................................... 222
Chapterz23:zObesityzandzDisorderszofzNutrition ......................................................................................... 234
Chapterz24:zStructurezandzFunctionzofzthezReproductivezSystems ............................................................. 239
Chapterz25:zAlterationszofzthezFemalezReproductivezSystem..................................................................... 249
Chapterz26:zAlterationszofzthezMalezReproductivezSystem ........................................................................ 259
Chapterz27:zSexuallyzTransmittedzInfections ............................................................................................. 265
Chapterz28:zStructurezandzFunctionzofzthezHematologiczSystem................................................................ 273
Chapterz29:zAlterationszofzErythrocytes,zPlatelets,zandzHemostaticzFunction............................................ 283
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Chapterz30:zAlterationszofzLeukocytezandzLymphoidzFunction................................................................... 293
Chapterz31:zAlterationszofzHematologiczFunctionzinzChildren .................................................................... 300
Chapterz32:zStructurezandzFunctionzofzthezCardiovascularzandzLymphaticzSystems ................................... 311
Chapterz33:zAlterationszofzCardiovascularzFunction................................................................................... 324
Chapterz34:zAlterationszofzCardiovascularzFunctionzinzChildren ................................................................. 338
Chapterz35:zStructurezandzFunctionzofzthezPulmonaryzSystem .................................................................. 346
Chapterz36:zAlterationszofzPulmonaryzFunction ......................................................................................... 356
Chapterz37:zAlterationszofzPulmonaryzFunctionzinzChildren ....................................................................... 373
Chapterz38:zStructurezandzFunctionzofzthezRenalzandzUrologiczSystems..................................................... 381
Chapterz39:zAlterationszofzRenalzandzUrinaryzTractzFunction ..................................................................... 391
Chapterz40:zAlterationszofzRenalzandzUrinaryzTractzFunctionzinzChildren ................................................... 401
Chapterz41:zStructurezandzFunctionzofzthezDigestivezSystem ..................................................................... 409
Chapterz42:zAlterationszofzDigestivezFunction............................................................................................ 421
Chapterz43:zAlterationszofzDigestivezFunctionzinzChildren.......................................................................... 432
Chapterz44:zStructurezandzFunctionzofzthezMusculoskeletalzSystem.......................................................... 441
Chapterz45:zAlterationszofzMusculoskeletalzFunction ................................................................................ 453
Chapterz46:zAlterationszofzMusculoskeletalzFunctionzinzChildren .............................................................. 466
Chapterz47:zStructure,zFunction,zandzDisorderszofzthezIntegument ........................................................... 475
Chapterz48:zAlterationszofzthezIntegumentzinzChildren .............................................................................. 486
Chapterz49:zShock,zMultiplezOrganzDysfunctionzSyndrome,zandzBurnszinzAdults ....................................... 494
Chapterz50:zShock,zMultiplezOrganzDysfunctionzSyndrome,zandzBurnszinzChildren .................................... 502
, TestzBankz-zPathophysiology:zThezBiologiczBasiszforzDiseasezinzAdultszandzChildrenz(8th)z z z 4
Chapter 01: Cellular Biology
z z z
MULTIPLEzCHOICE
1. Whichzstatementzbestzdescribeszthezcellularzfunctionzofzmetaboliczabsorption?
a. Cellszcanzproducezproteins.
b. Cellszcanzsecretezdigestivezenzymes.
c. Cellszcanztakezinzandzuseznutrients.
d. Cellszcanzsynthesizezfats.
ANS:z C
Inzmetaboliczabsorption,zallzcellsztakezinzandzuseznutrientszandzotherzsubstanceszfromztheirzsurroundings
.zThezremainingzoptionszareznotzinclusivezinztheirzdescriptionszofzcellularzmetaboliczabsorption.
PTS:z z 1 DIF: CognitivezLevel:zRemembering
2. Whereziszmostzofzazcell’szgeneticzinformation,zincludingzRNAzandzDNA,zcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. Lysosome
ANS:z C
Theznucleuszcontainsztheznucleolus,zazsmallzdensezstructurezcomposedzlargelyzofzRNA,zmostzofzthez
cellularzDNA,zandzthezDNA-
bindingzproteins,zsuchzaszthezhistones,zwhichzregulatezitszactivity.zThezmitochondriazarezresponsibl
ezforzcellularzrespirationzandzenergyzproduction.
Ribosomes’zchiefzfunctionzisztozprovidezsiteszforzcellularzproteinzsynthesis.zLysosomeszfunctionzaszt
hezintracellularzdigestivezsystem.
PTS:z z 1 DIF: CognitivezLevel:zRemembering
3. Whichzcomponentzofzthezcellzproduceszhydrogenzperoxidez(H2O2)zbyzusingzoxygenztozremovezh
ydrogenzatomszfromzspecificzsubstrateszinzanzoxidativezreaction?
a. Lysosomes
b. Peroxisomes
c. Ribosomes
d. Endosome
ANS:z B