PATHOPHYSIOLOGY
THEBIOLOGICBASISFOR
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DISEASE IN ADULTS AND
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CHILDREN
8thEdition
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PATHOPHYSIOLOGY
THE BIOLOGIC BASIS FOR DISEASE IN ADULTS AND CHILDREN
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8th Edition
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Kathryn L. McCance, Sue E. Huether
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Contents
Chapterj01:jCellularjBiology ........................................................................................................................... 4
Chapterj02:jAlteredjCellularjandjTissuejBiology:jEnvironmentaljAgents ........................................................ 18
Chapterj03:jThejCellularjEnvironment:jFluidsjandjElectrolytes,jAcidsjandjBases............................................ 31
Chapterj04:jGenesjandjGeneticjDiseases ...................................................................................................... 44
Chapterj05:jGenes,jEnvironment-Lifestyle,jandjCommonjDiseases .............................................................. 55
Chapterj06:jEpigeneticsjandjDisease ............................................................................................................ 63
Chapterj07:jInnatejImmunity:jInflammationjandjWoundjHealing ................................................................. 68
Chapterj08:jAdaptivejImmunity.................................................................................................................... 83
Chapterj09:jAlterationsjinjImmunityjandjInflammation ................................................................................ 95
Chapterj10:jInfection.................................................................................................................................. 108
Chapterj11:jStressjandjDisease ................................................................................................................... 117
Chapterj12:jCancerjBiology ........................................................................................................................ 124
Chapterj13:jCancerjEpidemiology............................................................................................................... 137
Chapterj14:jCancerjinjChildren ................................................................................................................... 143
Chapterj15:jStructurejandjFunctionjofjthejNeurologicjSystem .................................................................... 148
Chapterj16:jPain,jTemperaturejRegulation,jSleep,jandjSensoryjFunction.................................................... 159
Chapterj17:jAlterationsjinjCognitivejSystems,jCerebraljHemodynamics,jandjMotorjFunction..................... 174
Chapterj18:jDisordersjofjthejCentraljandjPeripheraljNervousjSystemsjandjthejNeuromuscularjJunction
.................................................................................................................................................................. 188
Chapterj19:jNeurobiologyjofjSchizophrenia,jMoodjDisorders,jandjAnxietyjDisorders ................................. 199
Chapterj20:jAlterationsjofjNeurologicjFunctionjinjChildren ......................................................................... 206
Chapterj21:jMechanismsjofjHormonaljRegulation ...................................................................................... 213
Chapterj22:jAlterationsjofjHormonaljRegulation ........................................................................................ 222
Chapterj23:jObesityjandjDisordersjofjNutrition........................................................................................... 234
Chapterj24:jStructurejandjFunctionjofjthejReproductivejSystems ............................................................... 239
Chapterj25:jAlterationsjofjthejFemalejReproductivejSystem ...................................................................... 249
Chapterj26:jAlterationsjofjthejMalejReproductivejSystem .......................................................................... 259
Chapterj27:jSexuallyjTransmittedjInfections............................................................................................... 265
Chapterj28:jStructurejandjFunctionjofjthejHematologicjSystem.................................................................. 273
Chapterj29:jAlterationsjofjErythrocytes,jPlatelets,jandjHemostaticjFunction.............................................. 283
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Chapterj30:jAlterationsjofjLeukocytejandjLymphoidjFunction .................................................................... 293
Chapterj31:jAlterationsjofjHematologicjFunctionjinjChildren ...................................................................... 300
Chapterj32:jStructurejandjFunctionjofjthejCardiovascularjandjLymphaticjSystems ..................................... 311
Chapterj33:jAlterationsjofjCardiovascularjFunction .................................................................................... 324
Chapterj34:jAlterationsjofjCardiovascularjFunctionjinjChildren ................................................................... 338
Chapterj35:jStructurejandjFunctionjofjthejPulmonaryjSystem..................................................................... 346
Chapterj36:jAlterationsjofjPulmonaryjFunction .......................................................................................... 356
Chapterj37:jAlterationsjofjPulmonaryjFunctionjinjChildren ......................................................................... 373
Chapterj38:jStructurejandjFunctionjofjthejRenaljandjUrologicjSystems ....................................................... 381
Chapterj39:jAlterationsjofjRenaljandjUrinaryjTractjFunction ....................................................................... 391
Chapterj40:jAlterationsjofjRenaljandjUrinaryjTractjFunctionjinjChildren ...................................................... 401
Chapterj41:jStructurejandjFunctionjofjthejDigestivejSystem ....................................................................... 409
Chapterj42:jAlterationsjofjDigestivejFunction ............................................................................................. 421
Chapterj43:jAlterationsjofjDigestivejFunctionjinjChildren............................................................................ 432
Chapterj44:jStructurejandjFunctionjofjthejMusculoskeletaljSystem ............................................................ 441
Chapterj45:jAlterationsjofjMusculoskeletaljFunction ................................................................................. 453
Chapterj46:jAlterationsjofjMusculoskeletaljFunctionjinjChildren ................................................................ 466
Chapterj47:jStructure,jFunction,jandjDisordersjofjthejIntegument.............................................................. 475
Chapterj48:jAlterationsjofjthejIntegumentjinjChildren ................................................................................ 486
Chapterj49:jShock,jMultiplejOrganjDysfunctionjSyndrome,jandjBurnsjinjAdults .......................................... 494
Chapterj50:jShock,jMultiplejOrganjDysfunctionjSyndrome,jandjBurnsjinjChildren ...................................... 502