WGU C785 Biochemistry Unit Questions Latest
Update 2025-2026 Exam 70 Questions with 100%
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A final product of a four-step metabolic pathway serves as a noncompetitive inhibitor,
binding to an enzyme in this pathway and temporarily turning off the pathway. Which
enzyme is most likely to be targeted by the inhibitor?
The final enzyme in the pathway
The first enzyme in the pathway
Any enzyme in the middle of the pathway
The second enzyme in the pathway - CORRECT ANSWER: The first enzyme in the
pathway
The final product's structure is more unlike the substrate for the first enzyme in the
pathway than any other, and thus the least likely to fit the active site of enzyme 1.
A mutation in the beta-hemoglobin gene, which results in the replacement of the amino
acid glutamate in position 6 with the amino acid valine, leads to the development of
sickle cell anemia. The structures of glutamate and valine are shown below.
If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so
that the valine in position 6 was replaced with a different amino acid, which replacement
for valine would be expected to have the best clinical outcome, in theory, for the
patient? (Assume the valine can potentially be replaced with any amino acid other than
glutamate.) - CORRECT ANSWER: The original amino acid in a healthy patient is
glutamate, which is negatively charged. The mutated amino acid is valine, which is non-
,polar. Valine is causing sickle cell anemia. The best amino acid to replace valine so that
the patient is healthy again would be the one most like glutamate, so any negatively
charged amino acid.
A patient has received a large dose of ionizing radiation at his place of employment.
Which scenario is accurate?
Ligase removes a single damaged base and replaces it with a new nucleotide.
Double-stranded DNA breaks are being repaired by nonhomologous end joining, without
the use of a homologous template.
The homologous recombination pathway is upregulated and is facilitating the removal of
mismatched bases.
A string of damaged nucleotides is removed and replaced by a new nucleotide
sequence in the base excision repair pathway. - CORRECT ANSWER: Double-stranded
DNA breaks are being repaired by nonhomologous end joining, without the use of a
homologous template.
Due to the large dose of ionizing radiation, the patient has many double-stranded DNA
breaks, and undamaged homologous DNA is in short supply. Nonhomologous end-
joining will be used to fix these double-strand breaks.
A point mutation has altered the amino acid sequence of a neuronal tau protein, causing
serine (Ser) at position 202 to be mutated to proline (Pro). Which set of codons below
corresponds to this mutation?
TCT to CCT
AGA to GGA
,CGA to AGG
AGG to CCC - CORRECT ANSWER: TCT to CCT
TCT is a codon for Ser, and CCT is a codon for Pro. TCT to CCT is a point mutation that
changes Ser to Pro.
A portion of the HLA gene and its associated amino acid sequence are shown below. If
cytosine is deleted from codon 101, what will be the resulting amino acid sequence?
Ser Tyr Glu
Glu Met Leu
Glu Pro Cys
Glu His Ala Asp - CORRECT ANSWER: Glu Met Leu
Deletion of cytosine (C) from codon 101 leads to the DNA sequence 5'-GAG ATG CTG
AT-3', which corresponds to the amino acid sequence Glu Met Leu.
An increase in beta-pleated sheet structure in some brain proteins can lead to an
increase in amyloid deposit formation, characteristic of some neurodegenerative
diseases. What is the primary biochemical process that follows the increase in beta-
pleated sheet structure that leads to the development of the amyloid deposits?
An increase in glycogen formation in the brain cells
, Aggregation of the proteins in the brain
Secretion of glucagon, leading to excessive ketogenesis
An increase in anaerobic metabolism of glucose in the brain - CORRECT ANSWER:
Aggregation of the proteins in the brain
This question is describing changes in protein structure. Aggregation occurs when
proteins clump together inappropriately, causing plaques like amyloid deposits to
accumulate.
During aerobic metabolism, acetyl-CoA is produced from which molecule?
Glycerol
Lactate
Pyruvate
Oxaloacetate - CORRECT ANSWER: Pyruvate
Acetyl-COA is produced from the breakdown of pyruvate after glycolysis.
During gluconeogenesis, how many ATP molecules are consumed for each glucose
molecule produced?
4
Update 2025-2026 Exam 70 Questions with 100%
Verified Correct Answers Guaranteed A+
A final product of a four-step metabolic pathway serves as a noncompetitive inhibitor,
binding to an enzyme in this pathway and temporarily turning off the pathway. Which
enzyme is most likely to be targeted by the inhibitor?
The final enzyme in the pathway
The first enzyme in the pathway
Any enzyme in the middle of the pathway
The second enzyme in the pathway - CORRECT ANSWER: The first enzyme in the
pathway
The final product's structure is more unlike the substrate for the first enzyme in the
pathway than any other, and thus the least likely to fit the active site of enzyme 1.
A mutation in the beta-hemoglobin gene, which results in the replacement of the amino
acid glutamate in position 6 with the amino acid valine, leads to the development of
sickle cell anemia. The structures of glutamate and valine are shown below.
If the beta hemoglobin gene in a patient with sickle-cell anemia were to be edited so
that the valine in position 6 was replaced with a different amino acid, which replacement
for valine would be expected to have the best clinical outcome, in theory, for the
patient? (Assume the valine can potentially be replaced with any amino acid other than
glutamate.) - CORRECT ANSWER: The original amino acid in a healthy patient is
glutamate, which is negatively charged. The mutated amino acid is valine, which is non-
,polar. Valine is causing sickle cell anemia. The best amino acid to replace valine so that
the patient is healthy again would be the one most like glutamate, so any negatively
charged amino acid.
A patient has received a large dose of ionizing radiation at his place of employment.
Which scenario is accurate?
Ligase removes a single damaged base and replaces it with a new nucleotide.
Double-stranded DNA breaks are being repaired by nonhomologous end joining, without
the use of a homologous template.
The homologous recombination pathway is upregulated and is facilitating the removal of
mismatched bases.
A string of damaged nucleotides is removed and replaced by a new nucleotide
sequence in the base excision repair pathway. - CORRECT ANSWER: Double-stranded
DNA breaks are being repaired by nonhomologous end joining, without the use of a
homologous template.
Due to the large dose of ionizing radiation, the patient has many double-stranded DNA
breaks, and undamaged homologous DNA is in short supply. Nonhomologous end-
joining will be used to fix these double-strand breaks.
A point mutation has altered the amino acid sequence of a neuronal tau protein, causing
serine (Ser) at position 202 to be mutated to proline (Pro). Which set of codons below
corresponds to this mutation?
TCT to CCT
AGA to GGA
,CGA to AGG
AGG to CCC - CORRECT ANSWER: TCT to CCT
TCT is a codon for Ser, and CCT is a codon for Pro. TCT to CCT is a point mutation that
changes Ser to Pro.
A portion of the HLA gene and its associated amino acid sequence are shown below. If
cytosine is deleted from codon 101, what will be the resulting amino acid sequence?
Ser Tyr Glu
Glu Met Leu
Glu Pro Cys
Glu His Ala Asp - CORRECT ANSWER: Glu Met Leu
Deletion of cytosine (C) from codon 101 leads to the DNA sequence 5'-GAG ATG CTG
AT-3', which corresponds to the amino acid sequence Glu Met Leu.
An increase in beta-pleated sheet structure in some brain proteins can lead to an
increase in amyloid deposit formation, characteristic of some neurodegenerative
diseases. What is the primary biochemical process that follows the increase in beta-
pleated sheet structure that leads to the development of the amyloid deposits?
An increase in glycogen formation in the brain cells
, Aggregation of the proteins in the brain
Secretion of glucagon, leading to excessive ketogenesis
An increase in anaerobic metabolism of glucose in the brain - CORRECT ANSWER:
Aggregation of the proteins in the brain
This question is describing changes in protein structure. Aggregation occurs when
proteins clump together inappropriately, causing plaques like amyloid deposits to
accumulate.
During aerobic metabolism, acetyl-CoA is produced from which molecule?
Glycerol
Lactate
Pyruvate
Oxaloacetate - CORRECT ANSWER: Pyruvate
Acetyl-COA is produced from the breakdown of pyruvate after glycolysis.
During gluconeogenesis, how many ATP molecules are consumed for each glucose
molecule produced?
4
