ACUTE KIDNEY INJURY
By E. Oyieko
, INTRODUCTION
• Acute kidney injury (AKI) is rapid and usually reversible
decline in renal function as evident by rapid decline in
GFR overa period of hours to days .
• It may occur in patient with previously normal renal
function or patient with chronic kidney disease.
• In 2002 Acute Dialysis Quality Initiative(ADQI)
developed new definition/classification i.e. RIFLE -Risk,
Injury, Failure, Loss & ESKD.
• In 2007 Acute Kidney Injury Network (AKIN) had given
new criteria :
, RIFLE criteria
GFR Criteria Urine Output Criteria
RISK SCr>1.5 x baseline or UOP < 0.5mls/kg x 6hrs
GFR> 25% reduction
INJURY SCR > 2.0x baseline or UOP < 0.5 mls/kg x 12 hrs
GFR > 50 % reduction
failure SCr > 3.0 x baseline or UOP < 0.3mls/kg x 24 hrs or Anuria
GFR > 75% reduction or x 12 hrs
SCr > 4.0 mg/dl
loss Persistent Acute renal failure = complete loss of function for > 4 wks
ESRD End stage renal disease > 3 months
• For RIFLE increase in Serum creatinine should be both abrupt (within 1-
7 days) and sustained (>24 hours)
, AKIN criteria
•
• The increase in serum creatinine must occur in less than
48 hours
By E. Oyieko
, INTRODUCTION
• Acute kidney injury (AKI) is rapid and usually reversible
decline in renal function as evident by rapid decline in
GFR overa period of hours to days .
• It may occur in patient with previously normal renal
function or patient with chronic kidney disease.
• In 2002 Acute Dialysis Quality Initiative(ADQI)
developed new definition/classification i.e. RIFLE -Risk,
Injury, Failure, Loss & ESKD.
• In 2007 Acute Kidney Injury Network (AKIN) had given
new criteria :
, RIFLE criteria
GFR Criteria Urine Output Criteria
RISK SCr>1.5 x baseline or UOP < 0.5mls/kg x 6hrs
GFR> 25% reduction
INJURY SCR > 2.0x baseline or UOP < 0.5 mls/kg x 12 hrs
GFR > 50 % reduction
failure SCr > 3.0 x baseline or UOP < 0.3mls/kg x 24 hrs or Anuria
GFR > 75% reduction or x 12 hrs
SCr > 4.0 mg/dl
loss Persistent Acute renal failure = complete loss of function for > 4 wks
ESRD End stage renal disease > 3 months
• For RIFLE increase in Serum creatinine should be both abrupt (within 1-
7 days) and sustained (>24 hours)
, AKIN criteria
•
• The increase in serum creatinine must occur in less than
48 hours
