Breast cancer
Classification of breast cancer
based on expression ER HERZ
of
1,41111 iterate Friti 1
3 TNBC HER ER PR
based on site behaviour
DCS
cis
LCIS
Masa alobular
DC Other
colloid
papillary
tubular
medullary
Riskfactors elder age gender etc
T estrogen exposure
menarche late menopause
early
organochlorine hasestrogenic effects
geneticinheritance more risk in 1 relatives
lifestyle factors
pregcroyes risk Be
prolong breastfeed of
Pathogenesis
I Genetic inherited BC ADinheritance
mutations are seen in following
genes
BRCA
BRCAL
TP53
PTEN etc
DN b I b hom to
, DNA breaks
BRCA genes repair by homologous
recombination
BRCA also increase risk ovarian cancer
mostly TNBC
of
type
BRCA as I male BC
ERtve
I Sporadic B C
Luminal HERZ ve ER PR tve
estrogen enhance
proliferation
breast
ofepithelial cells
Type FAF peaces or lesio
transformation
to
malignancy
Tell groups at
risk
TER TPR well differentiated slowgrowin
HER no PR poor diff high proliferating
HER 2 it is receptorof TK
gene amplization of HERS
cell proliferation
apoptosis
plateau at middle
showgood prognosisageby HERZ antagonist
TNBC as I BRCAImeet
aggressivetype Treemence Gin syrs
ER ve P53 lobular epithelial cells P
Classification of breast cancer
based on expression ER HERZ
of
1,41111 iterate Friti 1
3 TNBC HER ER PR
based on site behaviour
DCS
cis
LCIS
Masa alobular
DC Other
colloid
papillary
tubular
medullary
Riskfactors elder age gender etc
T estrogen exposure
menarche late menopause
early
organochlorine hasestrogenic effects
geneticinheritance more risk in 1 relatives
lifestyle factors
pregcroyes risk Be
prolong breastfeed of
Pathogenesis
I Genetic inherited BC ADinheritance
mutations are seen in following
genes
BRCA
BRCAL
TP53
PTEN etc
DN b I b hom to
, DNA breaks
BRCA genes repair by homologous
recombination
BRCA also increase risk ovarian cancer
mostly TNBC
of
type
BRCA as I male BC
ERtve
I Sporadic B C
Luminal HERZ ve ER PR tve
estrogen enhance
proliferation
breast
ofepithelial cells
Type FAF peaces or lesio
transformation
to
malignancy
Tell groups at
risk
TER TPR well differentiated slowgrowin
HER no PR poor diff high proliferating
HER 2 it is receptorof TK
gene amplization of HERS
cell proliferation
apoptosis
plateau at middle
showgood prognosisageby HERZ antagonist
TNBC as I BRCAImeet
aggressivetype Treemence Gin syrs
ER ve P53 lobular epithelial cells P
