gms 6552: cell signaling and therapeutics review exam 1
questions with verified answers
a GRK inhibitor would have what effect on GPCR inactivation in the presence of a
GPCR agonist? Ans✓✓✓ it would decrease it
assume you have receptor antagonists that are able to stop receptor signaling
immediately. for which type of receptor would take the longest to see the effects
of your drug at the cellular level? Ans✓✓✓ nuclear receptors
based on the effects of the Nf-kB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit? Ans✓✓✓ increase
Beta-arrestin has what effect on ERK signaling? Ans✓✓✓ increases it
death ligands directly activate the ____ apoptotic pathway. Ans✓✓✓ extrinsic
different SMAD complexes bind different genes, which group of SMADs is
responsible for this specifically? Ans✓✓✓ R-Smads
does TGF-beta treatment cause cells to grow more of less in the soft agar assay?
Ans✓✓✓ more
how is the activity of the IKK complex modulated in order to determine.....
Ans✓✓✓ if the complex includes phosphorylated IKKbeta....
how many DNA binding domains do SMADs have? Ans✓✓✓ 1
, in the TGF-beta pathway, which protein becomes activated first upon binding of a
ligand? Ans✓✓✓ TGFBR2
is it more like for a GPCR agonist to bind near the N- or C- terminus of the
receptor? Ans✓✓✓ N terminus
is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or
GDP? Ans✓✓✓ GDP
many phospholipase C enzymes contain pleckstrin homology domains. what is the
function of these domains? Ans✓✓✓ bind phosphotidylinositol
observation of which of the following would be an indication of ongoing
apoptosis? Ans✓✓✓ membrane blebbing
overexpression of the BAK protein would be expected to ____ the rate of
apoptosis. Ans✓✓✓ increase
PI3K is an ______ protein. Ans✓✓✓ intracellular
PLC exerts some of its effects through the modulation of which physiological ion?
Ans✓✓✓ calcium
the beta-arrestin mediated internalization of GPCRs occurs through which
process? Ans✓✓✓ endocytosis
questions with verified answers
a GRK inhibitor would have what effect on GPCR inactivation in the presence of a
GPCR agonist? Ans✓✓✓ it would decrease it
assume you have receptor antagonists that are able to stop receptor signaling
immediately. for which type of receptor would take the longest to see the effects
of your drug at the cellular level? Ans✓✓✓ nuclear receptors
based on the effects of the Nf-kB signaling, would cancer cells be expected to
increase or decrease its activity for their own benefit? Ans✓✓✓ increase
Beta-arrestin has what effect on ERK signaling? Ans✓✓✓ increases it
death ligands directly activate the ____ apoptotic pathway. Ans✓✓✓ extrinsic
different SMAD complexes bind different genes, which group of SMADs is
responsible for this specifically? Ans✓✓✓ R-Smads
does TGF-beta treatment cause cells to grow more of less in the soft agar assay?
Ans✓✓✓ more
how is the activity of the IKK complex modulated in order to determine.....
Ans✓✓✓ if the complex includes phosphorylated IKKbeta....
how many DNA binding domains do SMADs have? Ans✓✓✓ 1
, in the TGF-beta pathway, which protein becomes activated first upon binding of a
ligand? Ans✓✓✓ TGFBR2
is it more like for a GPCR agonist to bind near the N- or C- terminus of the
receptor? Ans✓✓✓ N terminus
is it more likely to find a GPCR bound to a G-protein that is also bound to GTP or
GDP? Ans✓✓✓ GDP
many phospholipase C enzymes contain pleckstrin homology domains. what is the
function of these domains? Ans✓✓✓ bind phosphotidylinositol
observation of which of the following would be an indication of ongoing
apoptosis? Ans✓✓✓ membrane blebbing
overexpression of the BAK protein would be expected to ____ the rate of
apoptosis. Ans✓✓✓ increase
PI3K is an ______ protein. Ans✓✓✓ intracellular
PLC exerts some of its effects through the modulation of which physiological ion?
Ans✓✓✓ calcium
the beta-arrestin mediated internalization of GPCRs occurs through which
process? Ans✓✓✓ endocytosis
