NRNP 6665 Final Exam Test Questions with verified
answers
Aducanumab Ans✓✓✓ - Alzheimer's drug
- decreases amyloid plaques
Agomelatine Ans✓✓✓ Brand: Valdoxan
-Melatonin multimodal (Mel-MM)
-Agonist at melatonergic 1 and melatonergic 2 receptors
-Antagonist at 5HT2C receptors
-Not FDA approved: Rx for Depression, Generalized anxiety disorder
-Initial 25 mg/day at bedtime; after 2 weeks can increase to 50 mg/day at bedtime
Akathisia Ans✓✓✓ - motor restlessness, need to keep going, tx with
antiparkinsons meds, can be mistaken
for agitation
Akinesia Ans✓✓✓ loss or impairment of the power of voluntary movement
Amitriptyline (Elavil) Ans✓✓✓ Tricyclic antidepressant.
Amphetamine IR Ans✓✓✓ Adderall
CNS Stimulant
Amphetamine XR Ans✓✓✓ Adderall (XR) CNS Stimulant
,Amphetamines Ans✓✓✓ drugs that stimulate neural activity, causing speeded-
up body functions and associated energy and mood changes
Aripiprazole (Abilify) Ans✓✓✓ Treatment for depression. Atypical antipsychotic.
"Dopamine stabilizer". Dopamine receptor antagonist in high concentration and
also stimulates increase of dopamine in low concentrations. Side effects:
insomnia, akathisia.
Aripiprazole Ans✓✓✓ abilify/ antipsychotic (atypical)
S/sx: drowsiness
Atomoxetine (Strattera) Ans✓✓✓ - BBW
> Risk of suicidal ideation; monitor for suicidal thinking or behavior, worsening, or
unusual behavior
- Contraindications
> Glaucoma, pheochromocytoma, MAO I use within past 14 days
- Warning
> Rare, but severe hepatotoxicity (most within 120 days of start of treatment)
SE
> Headache, insomnia, *somnolence*, dry mouth, nausea, abdominal pain,
decrease in appetite, nausea, etc.
> Priapism
NOTE
> * do not open capsule * - irritant
> CYPD 2D6 substrate
,> watch out for *LIVER PROBLEMS *
Atomoxetine (Strattera) Ans✓✓✓ - BBW
> Risk of suicidal ideation; monitor for suicidal thinking or behavior, worsening, or
unusual behavior
- Contraindications
> Glaucoma, pheochromocytoma, MAO I use within past 14 days
- Warning
> Rare, but severe hepatotoxicity (most within 120 days of start of treatment)
SE
> Headache, insomnia, *somnolence*, dry mouth, nausea, abdominal pain,
decrease in appetite, nausea, etc.
> Priapism
NOTE
> * do not open capsule * - irritant
> CYPD 2D6 substrate
> watch out for *LIVER PROBLEMS *
Benadryl (diphenhydramine) Ans✓✓✓ Antihistamine used in akinesia, dystonia,
pseudo-Parkinson's
Brexpiprazole (Rexulti) Ans✓✓✓ Treatment for depression. Atypical
antipsychotic
, Bupropion (Wellbutrin) Ans✓✓✓ Antidepressant and smoking cessation aid, It
can treat depression and help people quit smoking. It can also prevent depression
caused by seasonal affective disorder (SAD).
Caprylidene Ans✓✓✓ Medical food approved by FDA for treatment of (AD)
Axona
Citalopram (Celexa) Ans✓✓✓ Antidepressant, SSRI: 20-40 mg qd.
Clomipramine (Anafranil) Ans✓✓✓ -Serotonin reuptake inhibitor (S-RI)
-Tricyclic antidepressant (TCA)
-Parent drug is a potent serotonin reuptake inhibitor
Active metabolite is a potent norepinephrine/noradrenaline reuptake inhibitor
-Increases serotonergic neurotransmission by blocking the serotonin reuptake
pump (transporter), -Desensitization of serotonin receptors, especially serotonin
1A receptors
-Increases noradrenergic neurotransmission by blocking the norepinephrine
reuptake pump (transporter), -Desensitization of beta adrenergic receptors
-Dopamine is inactivated by norepinephrine reuptake in the frontal cortex
-Lacks dopamine transporters
-Increases dopamine neurotransmission in this part of the brain
**FDA Approved for Pediatrics in tx Obsessive-compulsive disorder (OCD) (ages
10 and older)
*Off-Label for Pediatric Use: Depression, Severe and treatment-resistant,
depression, Cataplexy syndrome, Anxiety, Insomnia,
Neuropathic pain/chronic pain
answers
Aducanumab Ans✓✓✓ - Alzheimer's drug
- decreases amyloid plaques
Agomelatine Ans✓✓✓ Brand: Valdoxan
-Melatonin multimodal (Mel-MM)
-Agonist at melatonergic 1 and melatonergic 2 receptors
-Antagonist at 5HT2C receptors
-Not FDA approved: Rx for Depression, Generalized anxiety disorder
-Initial 25 mg/day at bedtime; after 2 weeks can increase to 50 mg/day at bedtime
Akathisia Ans✓✓✓ - motor restlessness, need to keep going, tx with
antiparkinsons meds, can be mistaken
for agitation
Akinesia Ans✓✓✓ loss or impairment of the power of voluntary movement
Amitriptyline (Elavil) Ans✓✓✓ Tricyclic antidepressant.
Amphetamine IR Ans✓✓✓ Adderall
CNS Stimulant
Amphetamine XR Ans✓✓✓ Adderall (XR) CNS Stimulant
,Amphetamines Ans✓✓✓ drugs that stimulate neural activity, causing speeded-
up body functions and associated energy and mood changes
Aripiprazole (Abilify) Ans✓✓✓ Treatment for depression. Atypical antipsychotic.
"Dopamine stabilizer". Dopamine receptor antagonist in high concentration and
also stimulates increase of dopamine in low concentrations. Side effects:
insomnia, akathisia.
Aripiprazole Ans✓✓✓ abilify/ antipsychotic (atypical)
S/sx: drowsiness
Atomoxetine (Strattera) Ans✓✓✓ - BBW
> Risk of suicidal ideation; monitor for suicidal thinking or behavior, worsening, or
unusual behavior
- Contraindications
> Glaucoma, pheochromocytoma, MAO I use within past 14 days
- Warning
> Rare, but severe hepatotoxicity (most within 120 days of start of treatment)
SE
> Headache, insomnia, *somnolence*, dry mouth, nausea, abdominal pain,
decrease in appetite, nausea, etc.
> Priapism
NOTE
> * do not open capsule * - irritant
> CYPD 2D6 substrate
,> watch out for *LIVER PROBLEMS *
Atomoxetine (Strattera) Ans✓✓✓ - BBW
> Risk of suicidal ideation; monitor for suicidal thinking or behavior, worsening, or
unusual behavior
- Contraindications
> Glaucoma, pheochromocytoma, MAO I use within past 14 days
- Warning
> Rare, but severe hepatotoxicity (most within 120 days of start of treatment)
SE
> Headache, insomnia, *somnolence*, dry mouth, nausea, abdominal pain,
decrease in appetite, nausea, etc.
> Priapism
NOTE
> * do not open capsule * - irritant
> CYPD 2D6 substrate
> watch out for *LIVER PROBLEMS *
Benadryl (diphenhydramine) Ans✓✓✓ Antihistamine used in akinesia, dystonia,
pseudo-Parkinson's
Brexpiprazole (Rexulti) Ans✓✓✓ Treatment for depression. Atypical
antipsychotic
, Bupropion (Wellbutrin) Ans✓✓✓ Antidepressant and smoking cessation aid, It
can treat depression and help people quit smoking. It can also prevent depression
caused by seasonal affective disorder (SAD).
Caprylidene Ans✓✓✓ Medical food approved by FDA for treatment of (AD)
Axona
Citalopram (Celexa) Ans✓✓✓ Antidepressant, SSRI: 20-40 mg qd.
Clomipramine (Anafranil) Ans✓✓✓ -Serotonin reuptake inhibitor (S-RI)
-Tricyclic antidepressant (TCA)
-Parent drug is a potent serotonin reuptake inhibitor
Active metabolite is a potent norepinephrine/noradrenaline reuptake inhibitor
-Increases serotonergic neurotransmission by blocking the serotonin reuptake
pump (transporter), -Desensitization of serotonin receptors, especially serotonin
1A receptors
-Increases noradrenergic neurotransmission by blocking the norepinephrine
reuptake pump (transporter), -Desensitization of beta adrenergic receptors
-Dopamine is inactivated by norepinephrine reuptake in the frontal cortex
-Lacks dopamine transporters
-Increases dopamine neurotransmission in this part of the brain
**FDA Approved for Pediatrics in tx Obsessive-compulsive disorder (OCD) (ages
10 and older)
*Off-Label for Pediatric Use: Depression, Severe and treatment-resistant,
depression, Cataplexy syndrome, Anxiety, Insomnia,
Neuropathic pain/chronic pain
