ASSINGMENT- SBC 702 (METABOLISM)
Mechanism and theories
of OXIDATIVE
PHOSPHORYLATION and
uncouplers of oxidative
phosphorylation
, Oxidative phosphorylation vs electron transport chain
related
-closely processes
in cellular respiration but
they are not the same.
> Electron transport chain > series
of protein complexes (1-1v) and electron carriers
(eg ubiquinone
: and
cytochrome c embedded in the inner mitochondrial membrane.
<
transfer electrons
from NADH and FADH to
Oxygen ,
forming water
.
is
through the chain
protons (ions pumped from mitochondrial
·
more ,
are
matrix to intermembrane
the
space proton gradient
.
-does not
produce ATP
directly establishes the conditions
necessary for ATP
Synthesis .
Phosphorylation Synthase
1
ETC
Oxidative
Synthesis by
ATP
-
>
> + ATP
I
gradient (through E-C) Synthase allows protons
Proton drives to back into
> ATP
flow
the matrix
connecting
ADP + Pi < ATP
>
Oxidative because
depends on as
final e-acceptor
the and
phosphorylation
because
generated from
ATP is ADP .
, Theories of oxidative phosphorylation
There 3
hypothesis that explain how the
transfer between electron
transport and
-
principle
are
energy
ATP takes
Synthes
is
place
Chemical
Coupling Theory
. The
1
.
2 The
conformational Coupling Theory
The chemiosmotic
3
Theory
.
1. The chemical coupling theory
Slater oxidation component of released
1953
suggested that
during the of ETC the is
trapped
·
a
,
energy
and
by the
formation of a bond-between that component some other molecule that is not
the
part of the chain
.
G-3-Pdehydrogenase directly incorporated
into
glyceraldehype-3-p
Pi is
examples 3
phosphoglycerate
> > > one
of the
products of redox
kinase
3-phosphoglycerate
r/n (1 ,
3-bisphosphoglycerate)
Succinate thiokinase a reactive intermediate
(Succingl CoA) without
Succinate
3
Succingl COA > P is
into ATP.
generated
which is
subsequently transformed
Mechanism and theories
of OXIDATIVE
PHOSPHORYLATION and
uncouplers of oxidative
phosphorylation
, Oxidative phosphorylation vs electron transport chain
related
-closely processes
in cellular respiration but
they are not the same.
> Electron transport chain > series
of protein complexes (1-1v) and electron carriers
(eg ubiquinone
: and
cytochrome c embedded in the inner mitochondrial membrane.
<
transfer electrons
from NADH and FADH to
Oxygen ,
forming water
.
is
through the chain
protons (ions pumped from mitochondrial
·
more ,
are
matrix to intermembrane
the
space proton gradient
.
-does not
produce ATP
directly establishes the conditions
necessary for ATP
Synthesis .
Phosphorylation Synthase
1
ETC
Oxidative
Synthesis by
ATP
-
>
> + ATP
I
gradient (through E-C) Synthase allows protons
Proton drives to back into
> ATP
flow
the matrix
connecting
ADP + Pi < ATP
>
Oxidative because
depends on as
final e-acceptor
the and
phosphorylation
because
generated from
ATP is ADP .
, Theories of oxidative phosphorylation
There 3
hypothesis that explain how the
transfer between electron
transport and
-
principle
are
energy
ATP takes
Synthes
is
place
Chemical
Coupling Theory
. The
1
.
2 The
conformational Coupling Theory
The chemiosmotic
3
Theory
.
1. The chemical coupling theory
Slater oxidation component of released
1953
suggested that
during the of ETC the is
trapped
·
a
,
energy
and
by the
formation of a bond-between that component some other molecule that is not
the
part of the chain
.
G-3-Pdehydrogenase directly incorporated
into
glyceraldehype-3-p
Pi is
examples 3
phosphoglycerate
> > > one
of the
products of redox
kinase
3-phosphoglycerate
r/n (1 ,
3-bisphosphoglycerate)
Succinate thiokinase a reactive intermediate
(Succingl CoA) without
Succinate
3
Succingl COA > P is
into ATP.
generated
which is
subsequently transformed
