Thrombocytopenia
.Pathological condition which is characterized by the decreased amount of thrombocytes in
the blood.
9 9
Number:150-400.10 / l ( Less than 150.10 / l)
-Function tests:adhesion/aggregation
-Tests for granules:ELISA
*Platelets contain α-granules and dense granules, which are essential for clot
formation.
Classification:
-Quantitative:thrombocytopenia
(! pseudothrombocytopenia!)- This is an artificially low platelet count caused by
laboratory errors rather than an actual decrease in circulating platelets.
-Qualitative:thrombocytopathia
Megakaryocyte Dysplastic megakaryocyte
-A megakaryocyte is a large cell with an eccentric multilobulated nucleus and
granular cytoplasm.
-Dysplastic megakaryocyte with hyperlobulation and discreet segmentation of the
nucleus.
, Causes :
-Low production in the bone marrow
-Increased breakdown in the bloodstream ( called intravascular)
-Increased breakdown in the spleen or liver ( called extravascular)
Disorders that involve low production in the bone marrow include :
.Aplastic anemia → a rare but serious blood condition that occurs when your bone
marrow cannot make enough new blood cells for your body to work normally.
.Cancer in the bone marrow
.Cirrhosis(Chronic liver disease)
.Folate(vitamin B-9) deficiency
.Infections in the bone marrow (very rare)
.Myelodysplasia → affects blood stem cells.
.Vitamin B12 deficiency
.Pathological condition which is characterized by the decreased amount of thrombocytes in
the blood.
9 9
Number:150-400.10 / l ( Less than 150.10 / l)
-Function tests:adhesion/aggregation
-Tests for granules:ELISA
*Platelets contain α-granules and dense granules, which are essential for clot
formation.
Classification:
-Quantitative:thrombocytopenia
(! pseudothrombocytopenia!)- This is an artificially low platelet count caused by
laboratory errors rather than an actual decrease in circulating platelets.
-Qualitative:thrombocytopathia
Megakaryocyte Dysplastic megakaryocyte
-A megakaryocyte is a large cell with an eccentric multilobulated nucleus and
granular cytoplasm.
-Dysplastic megakaryocyte with hyperlobulation and discreet segmentation of the
nucleus.
, Causes :
-Low production in the bone marrow
-Increased breakdown in the bloodstream ( called intravascular)
-Increased breakdown in the spleen or liver ( called extravascular)
Disorders that involve low production in the bone marrow include :
.Aplastic anemia → a rare but serious blood condition that occurs when your bone
marrow cannot make enough new blood cells for your body to work normally.
.Cancer in the bone marrow
.Cirrhosis(Chronic liver disease)
.Folate(vitamin B-9) deficiency
.Infections in the bone marrow (very rare)
.Myelodysplasia → affects blood stem cells.
.Vitamin B12 deficiency
