What is one characteristic of a non-healing wound? - ANSWER-persistent high levels of
pro-inflammatory MMPs
What are the 3 guidelines for active therapies for non-healing wounds - ANSWER-use
only for wounds that are clean, non-granulating (uninfected)
if wound necrotic-debride first
if wound infected- antibiotic first
Protease inhibitors - ANSWER-controls levels of inflammatory enzymes
matrix dressings - ANSWER-scaffolding to aid in cell migration and attachment
cell and tissue substitutes - ANSWER-provides cells and growth factors to promote
healing
How long would you use a protease inhibitor dressing if no response? - ANSWER-2
weeks
What are the theoretical basis for Acellular matrix dressings? - ANSWER-Provides
scaffolding for cell migration and attachment
controls cellular communication
provides proliferative signals to cells