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1. What is the MOA of daptomycin? binds to cells membrane
causing rapid depolariza-
tion of the membrane po-
tential . loss of membrane
lead to cell death
2. Against which type of bacteria is daptomycin effective gram-positive bacteria
in only
3. What is daptomycin approve for it use treat complicated skin and
skin structure infections
4. Which bacteria do daptomycin treats staph. aureus ,
MRSA,MRSE, VISA , E. fae-
calis and E. faecium and
VRE
5. Which infection is daptomycin not used in pneumonia
6. What should be monitored when pt is taking dapto- CPK
mycin
7. What is the adverse effect for pt taking daptomycin myositis and rhabdomyol-
ysis
8. What type of drug is Streptogramin quinupristin/dalfopristin
(Q/D)
9. Streptogramins (Q/D) binds to 50s
10. Streptogramins (Q/D) is active against most gram-pos- E. faecalis
itive bacteria except for
11. Which bacteria can be treated by Q/D
, MRSA/MRSE- Agents against Actual Exam Questions With
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gram positive such as
MRSA ,VISA, and VRE
but also have activity
against chlamydia, my-
coplasma and legionella
12. What are the side effects for Q/D infusion- related toxicities,
arthralgias and myalgias,
hyperbilirubemia
13. Q/D is metabolized by in the liver and has CYP 450
many drug interaction
14. How is streptogramin given? IV which is crystalize in the
presence of saline and is
administer central line
15. What do you linezolid for VRE
16. What is the MOA for linezolid inhibits monoamine oxi-
dase
17. What should pt avoid when taking oxazolidinones tyramine containing foods
such as linezolid , SSRI, triptans---> sero-
tonin syndrome
18. What is a side effect of linezolid thrombocytopenia , optic
neuritis and peripheral
19. What does Fidaxomicin treat? C. ditt
20. What is the MOA of Fidaxomicin inhibits mRNA synthesis
through inhibition of tran-
scriptions that is depen-