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Pathogenicity and mode of transmission

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It refers study of pathogenicity and mode of transmission and control measures

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Study of pathogenicity, mode of transmission and control measures of
dengue


Aim: Study of pathogenicity, mode of transmission and control measures of dengue
Introduction:
Dengue is a viral infection spread by the bite of an infected mosquito. It can cause a
range of symptoms, from mild fever to severe dengue, a life-threatening condition. About half
of the world's population is now at risk of dengue with an estimated 100–400 million infections
occurring each year. Dengue is found in tropical and sub-tropical climates worldwide, mostly
in urban and semi-urban areas. Dengue virus is most frequently transmitted by the bite of
mosquitos Aedes aegypti. Humans are the primary host of the virus, but it also circulates in
nonhuman primates, and can infect other mammals.




Figure No. 1: Aedes aegypti.
Transmission
Transmission of these viruses to humans happens through the bites of an infected
mosquito. The most common types of mosquitoes responsible for spreading dengue fever are
Aedes aegypti and Aedes albopictus mosquitoes. when an infected mosquito bites a person, the
virus initially enters the bloodstream, targets the liver, and then propagates to other organs. It
replicates there and impairs the liver's functioning, accumulating toxins in the blood, resulting
in fever, muscle pain, headache, and rash. If not managed, its severity may cause liver failure.
The spread of the virus to the bone marrow leads to reduced numbers of platelets, which are
necessary for effective blood clotting; this increases the risk of bleeding, the other major
complication of dengue fever.

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March 25, 2025
Number of pages
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2024/2025
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Dr joyti chintanchale
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