Albuterol
-increases levels of digoxin
-safe if children
-first line therapy
Etidronate (Didronel)
Bisphosphonates
-90 day half life
-preg cat B
reduces bone reabsorption
TX: low bone density, d/t cystic fibrosis, pagets disease (monitor xrays and labs), heterotropic
ossification, hip replacement, spinal cord injury
CI: entercolitis
Alendeonate (fosamax)
Biphosphonates
-10 yr. half life
( $cheapest)
TX: osteoporosis men, postmenopausal women, gluccorticoids induced, pagets diseae
bioavailability of biphosphonates
histamine 2 blocking, ranitadine agents double ALENDRONATE
TILUDRONATE decrease 50 % by aspirin and is increased by INDOMENTHACIN *consider
each nsaid individually
Anastozole, letroxole, exemestane
aromatase inhibitors
*hormone therapy to tx hormone receptor positive breast cancer.
AE: vertigo, insomnia, sleepiness, confusion, LIFE THREATENING BLOOD CLOTTING,
LOSS BONE MASS,
*take Ca+ vit D supplementation
*measure bone density
GH (somatotropin)
*used in children with GH deficiency treats hypoglycemia
Biophosphanates pt education
*empty stomach 8 oz water
avoid anitacids/ alcohol
ETIDRONATE increase in fx with pagets disease monitor labs and xrays
drugs associated with bone loss that should be monitored
aromatase inhibitors, thyroid hormones, gluccocorticoid, PPI, SSRI
Antidiabetic mediations to avoid in elderly
Sulfonylureas -hypoglycemia
Glimpride
Glyburide- most likely to cause hypo
metformin *renal insuffiency HF
Alpha-glycosidase inhibitors- not well tolerated
Screening of Type 2 DM
>45 yrs old BMI >25 *test yearly
>45 yrs old BMI WNL *q 3 yrs
<45 yrs old VMI >25* test more frequent.
-increases levels of digoxin
-safe if children
-first line therapy
Etidronate (Didronel)
Bisphosphonates
-90 day half life
-preg cat B
reduces bone reabsorption
TX: low bone density, d/t cystic fibrosis, pagets disease (monitor xrays and labs), heterotropic
ossification, hip replacement, spinal cord injury
CI: entercolitis
Alendeonate (fosamax)
Biphosphonates
-10 yr. half life
( $cheapest)
TX: osteoporosis men, postmenopausal women, gluccorticoids induced, pagets diseae
bioavailability of biphosphonates
histamine 2 blocking, ranitadine agents double ALENDRONATE
TILUDRONATE decrease 50 % by aspirin and is increased by INDOMENTHACIN *consider
each nsaid individually
Anastozole, letroxole, exemestane
aromatase inhibitors
*hormone therapy to tx hormone receptor positive breast cancer.
AE: vertigo, insomnia, sleepiness, confusion, LIFE THREATENING BLOOD CLOTTING,
LOSS BONE MASS,
*take Ca+ vit D supplementation
*measure bone density
GH (somatotropin)
*used in children with GH deficiency treats hypoglycemia
Biophosphanates pt education
*empty stomach 8 oz water
avoid anitacids/ alcohol
ETIDRONATE increase in fx with pagets disease monitor labs and xrays
drugs associated with bone loss that should be monitored
aromatase inhibitors, thyroid hormones, gluccocorticoid, PPI, SSRI
Antidiabetic mediations to avoid in elderly
Sulfonylureas -hypoglycemia
Glimpride
Glyburide- most likely to cause hypo
metformin *renal insuffiency HF
Alpha-glycosidase inhibitors- not well tolerated
Screening of Type 2 DM
>45 yrs old BMI >25 *test yearly
>45 yrs old BMI WNL *q 3 yrs
<45 yrs old VMI >25* test more frequent.
