3/24/25, 6:00 NR507 Midterm Study guide Flashcards |
PM
NR507 MIDTERM STUDY GUIDE EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS VERIFIED
Practice questions for this set
Learn 1/7 Study using Learn
<60ml/min for 3 months or longer
Select the correct term
what are kinds of restrictive pulmonary
1describe stage D heart failure
2disease
3what GFR quantifies CKF
4how is acute pyelonephritis diagnosed
Don't know?
Terms in this set (153)
IgE
What is Type 1 reaction mediated by?
*inflammation r/t mast cell degranulation
What are the local symptoms of Type itching, rash
1 reaction?
What are systemic reactions of Type 1? wheezing
anaphylactic reaction
What is the most dangerous form of type
*systemic response-hypotension, severe bronchoconstriction
1 reaction?
*epinephrine to reverse effects
cytotoxic reaction-tissue specific
What kind of reaction is type 2? *machrophages are primary effector cells involved
*can cause tissue damage or alter function
What are examples of type 2 Graves' disease
hypersensitivity? transfusion reaction
incompatible blood type causes cell/tissue damage
What happens in a transfusion reaction?
*erythrocytes are destroyed by agglutination or complete-mediated lysis
the action of TSH, binding to the receptors on thyroid cells
In Graves' disease TSI's mimic what? *binding stimulates production and release of excessive thyroid hormones (T3-
T4) even in absence of TSH
What are key characteristics of Graves' autoantibody mediated-caused by IgG targeting TSH receptors
disease? stimulatory not cytotoxic- involves cell overstimulation
1/
7
, 3/24/25, 6:00 NR507 Midterm Study guide Flashcards |
PM
What are common symptoms of Graves increased metabolism, sweating, tremors, bulging eyes (exophthalmos)
disease?
Immune complex mediated-complexes formed in blood and are deposited in
What type of hypersensitivity as type 3?
various tissues
when soluble antigens (foreign proteins, drugs, microbial components) combine with
How is type 3 triggered?
antibodies -primarily IgG/IgM- form immune complexes
What does type 3 reaction lead to? inflammation and tissue damage
Where do type 3 immune complexes bl vessel walls, joints, glomeruli, tissues with small vessels
typically deposit themselves? * kidneys, lungs, skin, joints
Type 2- organ specific, binds to cell surface
What is the difference between type 2 and
type3-not organ specific-bind to the soluble antigen outside cell surface that was
type 3?
released into blood or body fluids, then deposited into tissue
RA-deposited into joints
What are type 3 axample?
SLE- deposit in organs that cause tissue damage
new or current symptoms worsen often triggered by stress, infection, sunlight,
What happens in SLE flare-up?
hormonal changes, certain medications
What symptoms are associated with SLE joint pain, fatigue, skin rash, kidney dysfunction, fever, chest pain
flare up?
How can SLE flare ups be managed? Use sunscreen, manage stress, avoid certain medications
What are medications for SLE NSAIDS, steroids, immunosupressive agents, antimalarials, biologics
management?
What are lifestyle and support mechanisms regular monitoring, sun protection, healthy lifestyle
for SLE?
general term used to describe individuals immune system reaction against antigens
on the tissues of other membranes
example-neonatal disease where maternal immune system becomes sensitized
What is alloimmunity?
against expressed by the fetus
-transplant rejection
-transfusion reaction
delayed response
Describe type 4 hypersensitivity
does not involve antigen/antibody complexes liek type 1,2,3
What is an example of type 4? poison ivy
type 1-atopic dermatitis usually characterized by widely distributed lesions
what is the difference between type 1 vs
type 4- contact dermatitis (delayed hypersensitivity) consists of lesions only at
type 4 rash reaction?
the site contact with the allergen
What is the key determinant in determining 1- immediate
type 1 vs type 4 rash 4- delayed several days followings i.e. poison ivy
topical steroid
*epi for type 1 anaphylaxis
How do you treat type 4 rash *antihistamines act on H1 receptors
*type 4 reaction does not involve mast cells and H1 receptors
*ABX not appropriate for allergic reaction
are result of single gene defect
What is primary immunodeficiency? *something lacking in immune system itself
*b-lymphocyte deficiency is one of the most severe forms
2/
7
PM
NR507 MIDTERM STUDY GUIDE EXAM QUESTIONS AND ANSWERS WITH
COMPLETE SOLUTIONS VERIFIED
Practice questions for this set
Learn 1/7 Study using Learn
<60ml/min for 3 months or longer
Select the correct term
what are kinds of restrictive pulmonary
1describe stage D heart failure
2disease
3what GFR quantifies CKF
4how is acute pyelonephritis diagnosed
Don't know?
Terms in this set (153)
IgE
What is Type 1 reaction mediated by?
*inflammation r/t mast cell degranulation
What are the local symptoms of Type itching, rash
1 reaction?
What are systemic reactions of Type 1? wheezing
anaphylactic reaction
What is the most dangerous form of type
*systemic response-hypotension, severe bronchoconstriction
1 reaction?
*epinephrine to reverse effects
cytotoxic reaction-tissue specific
What kind of reaction is type 2? *machrophages are primary effector cells involved
*can cause tissue damage or alter function
What are examples of type 2 Graves' disease
hypersensitivity? transfusion reaction
incompatible blood type causes cell/tissue damage
What happens in a transfusion reaction?
*erythrocytes are destroyed by agglutination or complete-mediated lysis
the action of TSH, binding to the receptors on thyroid cells
In Graves' disease TSI's mimic what? *binding stimulates production and release of excessive thyroid hormones (T3-
T4) even in absence of TSH
What are key characteristics of Graves' autoantibody mediated-caused by IgG targeting TSH receptors
disease? stimulatory not cytotoxic- involves cell overstimulation
1/
7
, 3/24/25, 6:00 NR507 Midterm Study guide Flashcards |
PM
What are common symptoms of Graves increased metabolism, sweating, tremors, bulging eyes (exophthalmos)
disease?
Immune complex mediated-complexes formed in blood and are deposited in
What type of hypersensitivity as type 3?
various tissues
when soluble antigens (foreign proteins, drugs, microbial components) combine with
How is type 3 triggered?
antibodies -primarily IgG/IgM- form immune complexes
What does type 3 reaction lead to? inflammation and tissue damage
Where do type 3 immune complexes bl vessel walls, joints, glomeruli, tissues with small vessels
typically deposit themselves? * kidneys, lungs, skin, joints
Type 2- organ specific, binds to cell surface
What is the difference between type 2 and
type3-not organ specific-bind to the soluble antigen outside cell surface that was
type 3?
released into blood or body fluids, then deposited into tissue
RA-deposited into joints
What are type 3 axample?
SLE- deposit in organs that cause tissue damage
new or current symptoms worsen often triggered by stress, infection, sunlight,
What happens in SLE flare-up?
hormonal changes, certain medications
What symptoms are associated with SLE joint pain, fatigue, skin rash, kidney dysfunction, fever, chest pain
flare up?
How can SLE flare ups be managed? Use sunscreen, manage stress, avoid certain medications
What are medications for SLE NSAIDS, steroids, immunosupressive agents, antimalarials, biologics
management?
What are lifestyle and support mechanisms regular monitoring, sun protection, healthy lifestyle
for SLE?
general term used to describe individuals immune system reaction against antigens
on the tissues of other membranes
example-neonatal disease where maternal immune system becomes sensitized
What is alloimmunity?
against expressed by the fetus
-transplant rejection
-transfusion reaction
delayed response
Describe type 4 hypersensitivity
does not involve antigen/antibody complexes liek type 1,2,3
What is an example of type 4? poison ivy
type 1-atopic dermatitis usually characterized by widely distributed lesions
what is the difference between type 1 vs
type 4- contact dermatitis (delayed hypersensitivity) consists of lesions only at
type 4 rash reaction?
the site contact with the allergen
What is the key determinant in determining 1- immediate
type 1 vs type 4 rash 4- delayed several days followings i.e. poison ivy
topical steroid
*epi for type 1 anaphylaxis
How do you treat type 4 rash *antihistamines act on H1 receptors
*type 4 reaction does not involve mast cells and H1 receptors
*ABX not appropriate for allergic reaction
are result of single gene defect
What is primary immunodeficiency? *something lacking in immune system itself
*b-lymphocyte deficiency is one of the most severe forms
2/
7
