WOUND HEALING CH. 2 EXAM 2025/2026
QUESTIONS WITH ANSWERS GRADED A+
Platelet Functions - - forms platelet plug to control bleeding
- secretes growth factors and chemotactic agents
PMN Functions - - 1st cells to site of injury
- scavenger
- kills bacteria
- cleans wound
- secretes inflammatory mediators & MMP's
Macrophage Functions - - directs repair process
- assists with killing bacteria & cleaning wound
- secretes growth factors and MMP's
Mast cell functions - - secretes enzymes
- secretes inflammatory mediators
What triggers wound healing ? - A change in polarity between epidermis and dermis with break
in skin (current of injury)
The epidermis is _______________ in intact skin compared to dermis. - electronegative
The epidermis is _______________ in wounded/broken skin compared to dermis. -
electropositive
Superficial wounds heal via - re-epithelialization
Deep wounds heal via - scar tissue formation
What are the 3 overlapping phases of wound healing? - Inflammation, proliferation, maturation
& remodeling
How long does the inflammatory phase last? - 0 to 7-10 days
How long does the proliferative phase last? - 3-28 days
How long does the remodeling phase last? - 6 mo to 1-2 years
What vascular response occurs during inflammatory phase? - vasoconstriction, vasodilation,
transudate/exudate, blood clot (platelets + fibrin plugs)
Describe the cellular events that occur during the inflammatory phase: - migration of PMN's &
macrophages
, phagocytosis
increased fibroblast activity
5 clinical events of inflammatory phase: - 1. redness (rubor)
2. heat (calor)
3. swelling (tumor)
4. pain (dolor)
5. loss of function
In what phase does granulation tissue form? - proliferative phase
What is granulation tissue? - collagen mixed with new capillaries
appears "beefy red"
4 cellular events of proliferative phase - 1. collagen synthesis via fibroblasts
2. angiogenesis
3. fibroblasts --> myofibroblasts
4. new epithelial growth
4 clinical events of proliferative phase - 1. granulation tissue forms
2. endothelial budding
3. wound contraction
4. re-epithelialization & contact inhibition
angiogenesis - formation of new blood vessels
contact inhibition - a process that stops additional cell growth when cells become crowded
migration continues until advancing cells from opposite sides of wound meet, causing _______
_______ of migration - contact inhibition
Epithelialization can occur from the _________ and/or _______ - wound edge,
from cells around hair follicles
What mediates wound contraction - extracellular matrix
What cells are the driving force of wound contraction? - myofibroblast
Which types of wounds contract the fastest? - linear wound
Which types of wounds contract the slowest? - Circular wounds
QUESTIONS WITH ANSWERS GRADED A+
Platelet Functions - - forms platelet plug to control bleeding
- secretes growth factors and chemotactic agents
PMN Functions - - 1st cells to site of injury
- scavenger
- kills bacteria
- cleans wound
- secretes inflammatory mediators & MMP's
Macrophage Functions - - directs repair process
- assists with killing bacteria & cleaning wound
- secretes growth factors and MMP's
Mast cell functions - - secretes enzymes
- secretes inflammatory mediators
What triggers wound healing ? - A change in polarity between epidermis and dermis with break
in skin (current of injury)
The epidermis is _______________ in intact skin compared to dermis. - electronegative
The epidermis is _______________ in wounded/broken skin compared to dermis. -
electropositive
Superficial wounds heal via - re-epithelialization
Deep wounds heal via - scar tissue formation
What are the 3 overlapping phases of wound healing? - Inflammation, proliferation, maturation
& remodeling
How long does the inflammatory phase last? - 0 to 7-10 days
How long does the proliferative phase last? - 3-28 days
How long does the remodeling phase last? - 6 mo to 1-2 years
What vascular response occurs during inflammatory phase? - vasoconstriction, vasodilation,
transudate/exudate, blood clot (platelets + fibrin plugs)
Describe the cellular events that occur during the inflammatory phase: - migration of PMN's &
macrophages
, phagocytosis
increased fibroblast activity
5 clinical events of inflammatory phase: - 1. redness (rubor)
2. heat (calor)
3. swelling (tumor)
4. pain (dolor)
5. loss of function
In what phase does granulation tissue form? - proliferative phase
What is granulation tissue? - collagen mixed with new capillaries
appears "beefy red"
4 cellular events of proliferative phase - 1. collagen synthesis via fibroblasts
2. angiogenesis
3. fibroblasts --> myofibroblasts
4. new epithelial growth
4 clinical events of proliferative phase - 1. granulation tissue forms
2. endothelial budding
3. wound contraction
4. re-epithelialization & contact inhibition
angiogenesis - formation of new blood vessels
contact inhibition - a process that stops additional cell growth when cells become crowded
migration continues until advancing cells from opposite sides of wound meet, causing _______
_______ of migration - contact inhibition
Epithelialization can occur from the _________ and/or _______ - wound edge,
from cells around hair follicles
What mediates wound contraction - extracellular matrix
What cells are the driving force of wound contraction? - myofibroblast
Which types of wounds contract the fastest? - linear wound
Which types of wounds contract the slowest? - Circular wounds
