,Focus on Nursing Pharmacology
Eighth Edition
,Focus on Nursing Pharmacology
Eighth Edition
Amy M. Karch, RN, MS, CNS
Associate Professor of Clinical Nursing
University of Rochester School of Nursing
Rochester, New York
Rebecca G. Tucker, PhD, ACNPC, MEd, RN
Contributing Editor
Assistant Professor of Clinical Nursing
University of Rochester School of Nursing
Rochester, New York
, Vice President and Publisher: Julie K. Stegman
Director of Product Development: Jennifer K. Forestieri
Acquisitions Editor: Kelley Squazzo
Director of Nursing Content Publishing: Renee Gagliardi
Supervisory Development Editor: Staci Wolfson and Greg Nicholl
Marketing Manager: Brittany Clements
Editorial Assistant: Leo Gray
Editorial Coordinator: John Larkin
Designer: Teresa Mallon
Art Director: Jennifer Clements
Manufacturing Coordinator: Karin Duffield
Production Service: SPi Global
Eighth Edition
Copyright © 2020 Wolters Kluwer
Copyright © 2017, 2013, 2011, 2008, 2006, 2003, 2000 by Lippincott Williams & Wilkins.
All rights reserved. This book is protected by copyright. No part of this book may be reproduced or
transmitted in any form or by any means, including as photocopies or scanned-in or other electronic
copies, or utilized by any information storage and retrieval system without written permission from the
copyright owner, except for brief quotations embodied in critical articles and reviews. Materials
appearing in this book prepared by individuals as part of their official duties as U.S. government
employees are not covered by the above-mentioned copyright. To request permission, please contact
Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
, or via our website at shop.lww.com (products and services).
987654321
Printed in China
Cataloging-in-Publication Data available on request from the Publisher
ISBN: 978-1-9751-0096-4
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied,
including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’
examination of each patient and consideration of, among other things, age, weight, gender, current or
prior medical conditions, medication history, laboratory data and other factors unique to the patient.
The publisher does not provide medical advice or guidance and this work is merely a reference tool.
Healthcare professionals, and not the publisher, are solely responsible for the use of this work including
all medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional
verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and
treatment options should be made and healthcare professionals should consult a variety of sources.
When prescribing medication, healthcare professionals are advised to consult the product information
sheet (the manufacturer's package insert) accompanying each drug to verify, among other things,
Eighth Edition
,Focus on Nursing Pharmacology
Eighth Edition
Amy M. Karch, RN, MS, CNS
Associate Professor of Clinical Nursing
University of Rochester School of Nursing
Rochester, New York
Rebecca G. Tucker, PhD, ACNPC, MEd, RN
Contributing Editor
Assistant Professor of Clinical Nursing
University of Rochester School of Nursing
Rochester, New York
, Vice President and Publisher: Julie K. Stegman
Director of Product Development: Jennifer K. Forestieri
Acquisitions Editor: Kelley Squazzo
Director of Nursing Content Publishing: Renee Gagliardi
Supervisory Development Editor: Staci Wolfson and Greg Nicholl
Marketing Manager: Brittany Clements
Editorial Assistant: Leo Gray
Editorial Coordinator: John Larkin
Designer: Teresa Mallon
Art Director: Jennifer Clements
Manufacturing Coordinator: Karin Duffield
Production Service: SPi Global
Eighth Edition
Copyright © 2020 Wolters Kluwer
Copyright © 2017, 2013, 2011, 2008, 2006, 2003, 2000 by Lippincott Williams & Wilkins.
All rights reserved. This book is protected by copyright. No part of this book may be reproduced or
transmitted in any form or by any means, including as photocopies or scanned-in or other electronic
copies, or utilized by any information storage and retrieval system without written permission from the
copyright owner, except for brief quotations embodied in critical articles and reviews. Materials
appearing in this book prepared by individuals as part of their official duties as U.S. government
employees are not covered by the above-mentioned copyright. To request permission, please contact
Wolters Kluwer at Two Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
, or via our website at shop.lww.com (products and services).
987654321
Printed in China
Cataloging-in-Publication Data available on request from the Publisher
ISBN: 978-1-9751-0096-4
This work is provided “as is,” and the publisher disclaims any and all warranties, express or implied,
including any warranties as to accuracy, comprehensiveness, or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare professionals’
examination of each patient and consideration of, among other things, age, weight, gender, current or
prior medical conditions, medication history, laboratory data and other factors unique to the patient.
The publisher does not provide medical advice or guidance and this work is merely a reference tool.
Healthcare professionals, and not the publisher, are solely responsible for the use of this work including
all medical judgments and for any resulting diagnosis and treatments.
Given continuous, rapid advances in medical science and health information, independent professional
verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and
treatment options should be made and healthcare professionals should consult a variety of sources.
When prescribing medication, healthcare professionals are advised to consult the product information
sheet (the manufacturer's package insert) accompanying each drug to verify, among other things,
