QUESTIONgANDgANSWERSg(GRADEDgA)
g
1. Ifgagpatientgwithgsymptomsgofggastroesophagealgrefluxgdiseasegstatesgthatg
heghasgbeengself-
treatinggatghomegwithgOTCgranitidinegdaily,gthegappropriategtreatmentgwouldg
be:
Questiongoptions:
Prokineticg(metoclopramide)gforg4gtog8gweeksgPro
tongpumpginhibitorg(omeprazole)gforg12gweeks
Histamine2greceptorgantagonistg(ranitidine)gforg4gtog8gweeks
Cytoprotectivegdrugg(misoprostol)gforg2gweeks:gProtongpumpginhibitorg(omepra-
zole)gforg12gweeks
g
2. Beinggcompetentgingthegusegofginformationgtechnologygingclinicalgpracticeg
1g/g33
,isgexpectedgingprofessionalgnurses.gAdvancedgpracticegcompetencegincludesg
thegabilitygto:
Questiongoptions:
Searchgforginformationgusinggthegmostgcommongsearchgengines
Servegasgcontentgexpertsgingdeveloping,gimplementing,gandgevaluatingginfor-
mationgSystems
g
Writegprogramsgtogassuregthegintegritygofghealthginformation
Useginformationgtechnologygtogprescribegdrugs:gServegasgcontentgexpertsgingde
veloping,gimplementing,gandgevaluatingginformationgSystems
3. Thegfirst-linegtherapygforgmild-
persistentgasthmagis:gQuestiongoptions:
High-
dosegmontelukastgTheo
phylline
2g/g33
,Low-doseginhaledgcorticosteroids
Long-actinggbeta-2-agonists:gLow-doseginhaledgcorticosteroids
3g/g33
, 4. Drugsgthatghavegagsignificantgfirst-passgeffect:
Questiongoptions:
Mustgbeggivengbygthegenteralg(oral)groutegonlyg
Bypassgtheghepaticgcirculation
Aregrapidlygmetabolizedgbygtheglivergandgmayghaveglittlegifganygdesiredgaction
Aregconvertedgbygtheglivergtogmoregactivegandgfat-
solublegforms:gAregrapidlygmetabolizedgbygtheglivergandgmayghaveglittlegifganygde
siredgaction
5. Pharmacoeconomicsgis:
Questiongoptions:
ThegstudygofgthegpartgofgthegU.S.geconomygdevotedgtogdrugguse
Thegstudygofgthegimpactgofgprescriptiongdruggcostsgongthegoverallgeconomy
Theganalysisgofgthegcostsgandgconsequencesgofganyghealth-care-
relatedgtreatmentgorgservice
4g/g33