1|Page
FNP Review Dunphy Chapter 17 Endocrine and
Metabolic Problems Latest Questions with 100%
Correct Answers |2025
Which of the following medications can impact the functioning of the thyroid
gland?
A. Amiodarone, lithium, and interferon-alpha
B. Labetolol, lisinopril, and losartan
C. HCTZ, chlorthalidone, and losartan
D. Omeprazole, atorvastatin, and lisinopril - (answers)A. Amiodarone can cause
hyperthyroidism or hypothyroidism. Lithium and interferon-alpha can cause
thyroid dysfunction. Should have thyroid assessed periodically.
Early-morning increases in blood glucose concentration that occur with no
corresponding hypoglycemia during the night are referred to as:
a. the Somogyi phenomenon
b. insulin shock
c. diabetic ketoacidosis
d. the dawn phenomenon. - (answers)D
Diabetes and coronary artery disease (CAD) have a close interrelationship. Which
of the following statements about the relationship between diabetes and CAD is
true?
A. Hyperinsulinemia decreases sympathetic tone and cardiac contractility by
increasing plasma catecholamines, epinephrine, and norepinephrine
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B. An increase of glucose causes the distal nephrons of the kidneys to absorb less
sodium, resulting in more fluid, expanding the intravascular volume, and
increasing the blood pressure
C. Hyperinsulinemia causes a large number of vascular smooth muscle cells to be
formed and deposited on the walls of vessels, eventually decreasing space for
blood flow
D. An increase in glucose stimulates more secretion of epinephrine, thus raising
the blood pressure - (answers)C
Hyperinsulinemia causes a large number of vascular smooth muscle cells to be
formed and deposited on the walls of vessels, causing buildup and eventual
blockage, reducing blood flow; hyperinsulinemia increases (not decreases)
sympathetic tone and cardiac contractility by increasing plasma catecholamine,
epinephrine, and norepinephrine levels; and an increase in the glucose level
causes the distal nephrons of the kidneys to absorb more (not less) sodium,
resulting in more fluid, expanding the intravascular volume and increasing blood
pressure
What is the medication of choice for an initial acute attack of gout?
A. An NSAID
B. Colchicine
C. A corticosteroid
D. Allopurinol (Zyloprim) - (answers)A
Indomethacin (Indocin) is more commonly prescribed. An initial dose of 50-75mg
is given, followed by 25-50mg every 8 hours for 5-10 days. Naproxen is 750 mg,
followed by 250 mg every 8 hours for 5-10 days.
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Marsha, age 24, is preparing for radioactive iodine therapy for her Graves'
disease. Which test must she undergo first?
A. Beta human chorionic gonadotropin
B. Basal metabolism rate
C. Lithium level
D. Serum calcium - (answers)A
Contraindicated during pregnancy
When teaching Marcy how to use her new insulin pump, you tell her that she
needs to monitor her blood glucose level
A. at least once a day
B. only occasionally because glycemic levels are maintained very steadily
C. at least four times a day
D. on an as-needed basis when she feels she needs to give herself an extra dose
of insulin - (answers)C
Joan has severe asthma and has been on high doses of oral corticosteroids for 2
years. She has been reading some home remedy books and stops all of her
medications. What condition may she develop?
a. myxedema crisis
b. diabetes insipidus
c. hypoparathyroidism
d. addisonian crisis - (answers)D
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If a client has hepatitis, abdominal pain in the right upper quadrant is a result of
what patho-physiological basis?
A. Reduced prothrombin synthesis by injured hepatic cells
B. Bile salt accumulation
C. Release of pyrogens
D. Stretching of Glisson's capsule - (answers)D
How long after the acute illness of hepatitis A do immunoglobulin M anti-hepatitis
A virus titers disappear?
A. 1 week
B. 3 to 6 months
C. 1 year
D. 2 years - (answers)B
Which of the following individuals would not be a candidate for a
thiazolidinedione such as pioglitazone (Actos)?
A. A client with a history of hyperuricemia
B. A client with asthma
C. A client with heart failure
D. A client with sulfa allergy - (answers)C
Can exacerbate heart failure (Black Box warning)
FNP Review Dunphy Chapter 17 Endocrine and
Metabolic Problems Latest Questions with 100%
Correct Answers |2025
Which of the following medications can impact the functioning of the thyroid
gland?
A. Amiodarone, lithium, and interferon-alpha
B. Labetolol, lisinopril, and losartan
C. HCTZ, chlorthalidone, and losartan
D. Omeprazole, atorvastatin, and lisinopril - (answers)A. Amiodarone can cause
hyperthyroidism or hypothyroidism. Lithium and interferon-alpha can cause
thyroid dysfunction. Should have thyroid assessed periodically.
Early-morning increases in blood glucose concentration that occur with no
corresponding hypoglycemia during the night are referred to as:
a. the Somogyi phenomenon
b. insulin shock
c. diabetic ketoacidosis
d. the dawn phenomenon. - (answers)D
Diabetes and coronary artery disease (CAD) have a close interrelationship. Which
of the following statements about the relationship between diabetes and CAD is
true?
A. Hyperinsulinemia decreases sympathetic tone and cardiac contractility by
increasing plasma catecholamines, epinephrine, and norepinephrine
,2|Page
B. An increase of glucose causes the distal nephrons of the kidneys to absorb less
sodium, resulting in more fluid, expanding the intravascular volume, and
increasing the blood pressure
C. Hyperinsulinemia causes a large number of vascular smooth muscle cells to be
formed and deposited on the walls of vessels, eventually decreasing space for
blood flow
D. An increase in glucose stimulates more secretion of epinephrine, thus raising
the blood pressure - (answers)C
Hyperinsulinemia causes a large number of vascular smooth muscle cells to be
formed and deposited on the walls of vessels, causing buildup and eventual
blockage, reducing blood flow; hyperinsulinemia increases (not decreases)
sympathetic tone and cardiac contractility by increasing plasma catecholamine,
epinephrine, and norepinephrine levels; and an increase in the glucose level
causes the distal nephrons of the kidneys to absorb more (not less) sodium,
resulting in more fluid, expanding the intravascular volume and increasing blood
pressure
What is the medication of choice for an initial acute attack of gout?
A. An NSAID
B. Colchicine
C. A corticosteroid
D. Allopurinol (Zyloprim) - (answers)A
Indomethacin (Indocin) is more commonly prescribed. An initial dose of 50-75mg
is given, followed by 25-50mg every 8 hours for 5-10 days. Naproxen is 750 mg,
followed by 250 mg every 8 hours for 5-10 days.
,3|Page
Marsha, age 24, is preparing for radioactive iodine therapy for her Graves'
disease. Which test must she undergo first?
A. Beta human chorionic gonadotropin
B. Basal metabolism rate
C. Lithium level
D. Serum calcium - (answers)A
Contraindicated during pregnancy
When teaching Marcy how to use her new insulin pump, you tell her that she
needs to monitor her blood glucose level
A. at least once a day
B. only occasionally because glycemic levels are maintained very steadily
C. at least four times a day
D. on an as-needed basis when she feels she needs to give herself an extra dose
of insulin - (answers)C
Joan has severe asthma and has been on high doses of oral corticosteroids for 2
years. She has been reading some home remedy books and stops all of her
medications. What condition may she develop?
a. myxedema crisis
b. diabetes insipidus
c. hypoparathyroidism
d. addisonian crisis - (answers)D
, 4|Page
If a client has hepatitis, abdominal pain in the right upper quadrant is a result of
what patho-physiological basis?
A. Reduced prothrombin synthesis by injured hepatic cells
B. Bile salt accumulation
C. Release of pyrogens
D. Stretching of Glisson's capsule - (answers)D
How long after the acute illness of hepatitis A do immunoglobulin M anti-hepatitis
A virus titers disappear?
A. 1 week
B. 3 to 6 months
C. 1 year
D. 2 years - (answers)B
Which of the following individuals would not be a candidate for a
thiazolidinedione such as pioglitazone (Actos)?
A. A client with a history of hyperuricemia
B. A client with asthma
C. A client with heart failure
D. A client with sulfa allergy - (answers)C
Can exacerbate heart failure (Black Box warning)
