8RRD - Renal disorders
woensdag 17 april 2024
09:57
LE introduction to kidney function and disease2
Renal disorders
Glomerular diseases
Tubular disorders
Ciliopathies
Renal replacement therapy
Nephron --> functional unit of the kidney
Filtration unit
Around 1 million nephron structures
Disease ontology
Glomerular
Tubular
Vascular
Renal function = essential for homeostasis
--> kidneys play pleiotropic roles including
Removing metabolic waste products
Maintenance of water-electrolyte balance
Blood pressure
Night dialysis = at home
Hemodialysis --> excharge of fluids, blood dialysis with membrane
Excrete toxic components
Reabsorb valueble components
Transplantation is improved
Waiting time is high, but slows down (approx. 2 years)
Kidney disorders
, 6500 persons with dialysis, cost 80.000 - 100.000 euro/year
1000 donations/year
900 persons on waiting list
100 persons annually to late for kidney transplantation
How do kidneys works
Blood flow: 1400 L/day, 20% cardiac outpot
Filtrate: 180 L/day
Urine: 1.5 L/day
Kidney disease: 10% population
o Mild kidney failure
Threatening: 18.000 replacement therapy (dialysis)
Transporter proteins in the upper part of the functional part (nefron) of the kidney take up
electrolytes
o 1 million nefrons
o Glomerulus filters the blood
Afferent blood vene comes in
Podocytes are important for filtration process
Ultrafiltrate comes in approximal tubule
Then goes to Loop of Henle
Collecting in the collecting duct
Podocytes
o Bigger proteins stay in circulation
o Well organized mechanism
Filtration, reabsorption and secretion
Function kidney
o Bowman's capsule
Podocytes cells
Slid membrane between the cells
Quite selective process
o Proximal tubule: first secretion
o Lis van henle: water and salt
o Distal tube: second secretion of smaller particles
o Collecting duct: mostly water absorption
woensdag 17 april 2024
09:57
LE introduction to kidney function and disease2
Renal disorders
Glomerular diseases
Tubular disorders
Ciliopathies
Renal replacement therapy
Nephron --> functional unit of the kidney
Filtration unit
Around 1 million nephron structures
Disease ontology
Glomerular
Tubular
Vascular
Renal function = essential for homeostasis
--> kidneys play pleiotropic roles including
Removing metabolic waste products
Maintenance of water-electrolyte balance
Blood pressure
Night dialysis = at home
Hemodialysis --> excharge of fluids, blood dialysis with membrane
Excrete toxic components
Reabsorb valueble components
Transplantation is improved
Waiting time is high, but slows down (approx. 2 years)
Kidney disorders
, 6500 persons with dialysis, cost 80.000 - 100.000 euro/year
1000 donations/year
900 persons on waiting list
100 persons annually to late for kidney transplantation
How do kidneys works
Blood flow: 1400 L/day, 20% cardiac outpot
Filtrate: 180 L/day
Urine: 1.5 L/day
Kidney disease: 10% population
o Mild kidney failure
Threatening: 18.000 replacement therapy (dialysis)
Transporter proteins in the upper part of the functional part (nefron) of the kidney take up
electrolytes
o 1 million nefrons
o Glomerulus filters the blood
Afferent blood vene comes in
Podocytes are important for filtration process
Ultrafiltrate comes in approximal tubule
Then goes to Loop of Henle
Collecting in the collecting duct
Podocytes
o Bigger proteins stay in circulation
o Well organized mechanism
Filtration, reabsorption and secretion
Function kidney
o Bowman's capsule
Podocytes cells
Slid membrane between the cells
Quite selective process
o Proximal tubule: first secretion
o Lis van henle: water and salt
o Distal tube: second secretion of smaller particles
o Collecting duct: mostly water absorption
