2025 COMPLETE ACTUAL EXAM QUESTIONS
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SIGECAPS of Depression
Sleep disturbances
Interests are ↓
Guilt
Energy is ↓
Concentration is ↓
Appetite is ↓
Psychomotor Agitation
Suicidal thoughts
Major depressive disorder
Depressed Mood or Anhedonia
Dx: 5 or more of the SIGECAPS Sxs for > 2 wks effecting normal function
Tx:
,Psychotherapy
SSRI or SNRI > TCA/MAOi > ECT if refractory
What is the suspected pathophysiology of depression?
decreased 5HT, DA, NE, GABA and increased cortisol in the brain
S/Es of SSRIs
Sexual Dysfunction
Wt gain
Anxiety
Nausea
SHIVERS of Serotonin Syndrome
Shivering
Hyperreflexia
Increased temp (fever)
Vitals, unstable
Encephalopathy
Restless
Sweating
,Tx: Cyproheptadine
1st line Tx of depression in children
Fluoxetine (Prozac)
- Longest Half-life of all SSRIs
- Caution ↑ SI in the 1st 2 weeks of use
How long is the wash out period for Prozac?
5 weeks
SSRI known to cause QT interval prolongation
Citalopram (Celexa) and Escitalopram (Lexapro)
Screening tool or questionnaire used in clinic for:
Bipolar Disorder
Major Depression Disorder
BPD: The Mood Disorder Questionaire
, MDD: Beck Depression Inventory
Atypical Antidepressant which inhibits DA reuptake, has less sexual and wt-
related side effects, but decreases seizure threshold
Bupropion
smoking cessation
SNRI Trade Names
Effexor
Pristiq
Cymbalta
Fetzima
SNRI Drug Names
Venlafaxine
Desvenlafaxine
Duloxetine
Levomilnacipran
Which SNRI is indicated for fibromyalgia?
Duloxetine