SSA Molecules and tissues in inflammatory
diseases
Learning objectives:
1. Define common pathways and essential molecules in inflammatory
diseases
2. Explain necessary requirements in advanced cell cultures as models for
inflammatory disease
SSA1: Molecules and cells in inflammatory diseases
, 1. What is the inflammatory mechanism of Rheumatoid Arthritis?
Which cells are involved and which are the major cytokines?
Include the respective roles of the different cellular subsets and
which cytokines they produce. Think about and how the cells and
cytokines affect each other and how this relates to the disease.
RA = autoimmune disease characterized by chronic inflammation of the
joints, driven by an aberrant immune response that leads to synovial
(joint) inflammation and joint destruction.
Inflammatory mechanism: (in synovial membrane)
Immune cell activation, influx of inflammatory cells into the
synovium (slijmvlies holten van gewrichten)
Activation macrophages, T cells and release pro-inflammatory
cytokines (TNFalfa, IL6, IL1beta, IL17)
o Secretion IL17: promote macrophages activity, stimulate FLSs,
stimulate expression RANKL
diseases
Learning objectives:
1. Define common pathways and essential molecules in inflammatory
diseases
2. Explain necessary requirements in advanced cell cultures as models for
inflammatory disease
SSA1: Molecules and cells in inflammatory diseases
, 1. What is the inflammatory mechanism of Rheumatoid Arthritis?
Which cells are involved and which are the major cytokines?
Include the respective roles of the different cellular subsets and
which cytokines they produce. Think about and how the cells and
cytokines affect each other and how this relates to the disease.
RA = autoimmune disease characterized by chronic inflammation of the
joints, driven by an aberrant immune response that leads to synovial
(joint) inflammation and joint destruction.
Inflammatory mechanism: (in synovial membrane)
Immune cell activation, influx of inflammatory cells into the
synovium (slijmvlies holten van gewrichten)
Activation macrophages, T cells and release pro-inflammatory
cytokines (TNFalfa, IL6, IL1beta, IL17)
o Secretion IL17: promote macrophages activity, stimulate FLSs,
stimulate expression RANKL
