NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
1. What is pharma- - The biologic, chemical, and physiologic actions of a particular drug within the
codynamics? body
- What the drug does to the body
- The pharmacodynamics of a drug are responsible for its therapeutic effects and
sometimes adverse effects
2. What is pharma- - The study of drug movement throughout the body
cokinetics? - What the body does to the drug
- Absorption, distribution, metabolism, and excretion
3. What are the four - Replace or act as a substitute for missing chemicals
ways that drugs - To increase or stimulate certain cellular activities
work within the - To depress or slow cellular activities
body? - To interfere with the functioning of foreign cells
4. What is Absorption
the process Distribution
of pharmacoki- Metabolism
netics? (ADME) Excretion
5. What is absorp- - The movement of the drug from the site of administration into the bloodstream
tion? - What happens to a drug from the time it is introduced to the body until it reaches
the circulating fluids and tissues
6. What is distribu- The movement of the drugs into the cells and body tissues
tion?
7. What is biotrans- - The conversion of the drug into another substance or substances
formation (me- - Chemically converts drug so it can be easily removed from body
tabolism)?
8. What is excre-
tion?
, NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
- The removal of the drug
- Elimination of a drug or its metabolites from the body, most commonly via
kidneys (urine)
9. How are medica- The vast majority of medications are taken orally and are broken down within the
tions absorbed? gastrointestinal tract. Once the medication arrives, it is broken down by stomach
acids before it passes through the liver and then enters the bloodstream.
10. What factors af- - Dosage form
fect absorption - Route of administration
of medications? - Administration site blood flow
- GI function
- Presence of food or other drugs
11. What is metabo- Chemical alteration of the drug by the body
lism (biotransfor-
mation process)?
12. What is the first Loss of effectiveness during the first pass through the liver
pass effect?
13. What is protein Protein-bound drugs can't pass through capillary walls until bonds dissolve,
binding? How dosages calculated based on the protein-binding characteristics, Low "albumin
does it relate to level", more unbound, more toxicity
distribution?
14. What is the Cells in the capillary walls are tightly packed, keeps toxins and poisons out of the
blood brain bar- brain
rier? How does it
relate to distribu-
tion?
15.
, NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
Placenta mem- Not a barrier like the blood-brain barrier, any drug that can pass through a
brane and lacta- membrane can pas through the placenta, always ask if a pt is pregnant or lactating
tion, how does it
relate to distribu-
tion?
16. What is the he- Liver metabolism predominately achieved by specific liver enzymes called cy-
patic microsomal tochrome P-450
(P-450 enzyme)
system?
17. What is pharma- Genotyping for allleles that alllow for abnormal metabolism of certain drugs by
cogenomics? the P-450 sytem
18. What is the Elimination of a drug or its metabolites from the body, most commonly via kidneys
process of excre- (urine)
tion? Requires adequate function of:
- Circulatory system
- Kidneys, bowel
- Lungs
- Skin
19. What is the The amount of time required to remove half (50%) of the blood concentration of
half-life of a a drug
drug?
20. What factors that - Type of drug
can influence the - Quantity of drug used
actual effective- - Method of drug use
ness of drugs in - Time taken to consume
the body? - Tolerance
- Gender, size and amount of muscle
, NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
21. What is peptic ul- - Lesion in stomach called gastric ulcer
cer disease? - Lesion in small intestine called duodenal ulcer
- Symptoms: gnawing, burning pain, often occurring after meals
- Can occur in two different areas: gastric ulcer and duodenal ulcer
Two things to understand:
- Mucosal lining creates a barrier to protect stomach
- Then you have gastric acid
- Inadequate mucous or poor barrier can contribute to developing an ulcer,
medications such as NSAIDs and steroids can cause ulcers
22. What are the ad- A lot of meds that can have increased GI risk
verse affects that Ex. NSAIDs and steroids (prednisone)
drugs have on
the GI system?
23. What is heli- - Primary cause of peptic ulcers
cobacter pylori? - Mutates rapidly: that's the reason you have to have a multi drug treatment
24. What is the Should be nonpharmacologic
#1 treatment for - Watching what you eat
GERD? - Don't wear tight pants
- Don't lay down after eating
25. What causes Caused by loosening of sphincter between esophagus and stomach
GERD? Acidic stomach contents move up into esophagus
26. What are the ef- - Decrease GI secretory activity
fects of drugs on - Block the action of GI secretions
GI secretions? - Form protective coverings on the GI lining to prevent erosion from GI secretions
- Replace missing GI enzymes (pancrelipase) that the GI tract or ancillary glands
and organs can no longer produce
Study online at https://quizlet.com/_h11yo7
1. What is pharma- - The biologic, chemical, and physiologic actions of a particular drug within the
codynamics? body
- What the drug does to the body
- The pharmacodynamics of a drug are responsible for its therapeutic effects and
sometimes adverse effects
2. What is pharma- - The study of drug movement throughout the body
cokinetics? - What the body does to the drug
- Absorption, distribution, metabolism, and excretion
3. What are the four - Replace or act as a substitute for missing chemicals
ways that drugs - To increase or stimulate certain cellular activities
work within the - To depress or slow cellular activities
body? - To interfere with the functioning of foreign cells
4. What is Absorption
the process Distribution
of pharmacoki- Metabolism
netics? (ADME) Excretion
5. What is absorp- - The movement of the drug from the site of administration into the bloodstream
tion? - What happens to a drug from the time it is introduced to the body until it reaches
the circulating fluids and tissues
6. What is distribu- The movement of the drugs into the cells and body tissues
tion?
7. What is biotrans- - The conversion of the drug into another substance or substances
formation (me- - Chemically converts drug so it can be easily removed from body
tabolism)?
8. What is excre-
tion?
, NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
- The removal of the drug
- Elimination of a drug or its metabolites from the body, most commonly via
kidneys (urine)
9. How are medica- The vast majority of medications are taken orally and are broken down within the
tions absorbed? gastrointestinal tract. Once the medication arrives, it is broken down by stomach
acids before it passes through the liver and then enters the bloodstream.
10. What factors af- - Dosage form
fect absorption - Route of administration
of medications? - Administration site blood flow
- GI function
- Presence of food or other drugs
11. What is metabo- Chemical alteration of the drug by the body
lism (biotransfor-
mation process)?
12. What is the first Loss of effectiveness during the first pass through the liver
pass effect?
13. What is protein Protein-bound drugs can't pass through capillary walls until bonds dissolve,
binding? How dosages calculated based on the protein-binding characteristics, Low "albumin
does it relate to level", more unbound, more toxicity
distribution?
14. What is the Cells in the capillary walls are tightly packed, keeps toxins and poisons out of the
blood brain bar- brain
rier? How does it
relate to distribu-
tion?
15.
, NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
Placenta mem- Not a barrier like the blood-brain barrier, any drug that can pass through a
brane and lacta- membrane can pas through the placenta, always ask if a pt is pregnant or lactating
tion, how does it
relate to distribu-
tion?
16. What is the he- Liver metabolism predominately achieved by specific liver enzymes called cy-
patic microsomal tochrome P-450
(P-450 enzyme)
system?
17. What is pharma- Genotyping for allleles that alllow for abnormal metabolism of certain drugs by
cogenomics? the P-450 sytem
18. What is the Elimination of a drug or its metabolites from the body, most commonly via kidneys
process of excre- (urine)
tion? Requires adequate function of:
- Circulatory system
- Kidneys, bowel
- Lungs
- Skin
19. What is the The amount of time required to remove half (50%) of the blood concentration of
half-life of a a drug
drug?
20. What factors that - Type of drug
can influence the - Quantity of drug used
actual effective- - Method of drug use
ness of drugs in - Time taken to consume
the body? - Tolerance
- Gender, size and amount of muscle
, NUR334: Pharm Final Exam Questions and Correct Answers
Study online at https://quizlet.com/_h11yo7
21. What is peptic ul- - Lesion in stomach called gastric ulcer
cer disease? - Lesion in small intestine called duodenal ulcer
- Symptoms: gnawing, burning pain, often occurring after meals
- Can occur in two different areas: gastric ulcer and duodenal ulcer
Two things to understand:
- Mucosal lining creates a barrier to protect stomach
- Then you have gastric acid
- Inadequate mucous or poor barrier can contribute to developing an ulcer,
medications such as NSAIDs and steroids can cause ulcers
22. What are the ad- A lot of meds that can have increased GI risk
verse affects that Ex. NSAIDs and steroids (prednisone)
drugs have on
the GI system?
23. What is heli- - Primary cause of peptic ulcers
cobacter pylori? - Mutates rapidly: that's the reason you have to have a multi drug treatment
24. What is the Should be nonpharmacologic
#1 treatment for - Watching what you eat
GERD? - Don't wear tight pants
- Don't lay down after eating
25. What causes Caused by loosening of sphincter between esophagus and stomach
GERD? Acidic stomach contents move up into esophagus
26. What are the ef- - Decrease GI secretory activity
fects of drugs on - Block the action of GI secretions
GI secretions? - Form protective coverings on the GI lining to prevent erosion from GI secretions
- Replace missing GI enzymes (pancrelipase) that the GI tract or ancillary glands
and organs can no longer produce
