TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p
Chapter 01: Cellular Biology
p p p
MULTIPLEpCHOICE
1. Apstudentpispobservingpapcellpunderpthepmicroscope.pItpispobservedptophavepsupercoiledpDNAp
withphistones.pWhichpofpthepfollowingpwouldpalsopbepobservedpbypthepstudent?
a. Apsinglepcircularpchromosome
b. Apnucleus
c. Free-floatingpnuclearpmaterial
d. Noporganelles
ANS:p B
Thepcellpdescribedpispapeukaryoticpcell,psopitphasphistonespandpapsupercoiledpDNApwithinpitspnucl
eus;pthus,pthepnucleuspshouldpbepobserved.pApsinglepcircularpchromosomepcalledpapprokaryotepc
ontainspfree-floatingpnuclearpmaterialpbutphaspnoporganelles.
REF:p p.p2
2. Apnursepispinstructingpthepstaffpaboutpcellularpfunctions.pWhichpcellularpfunctionpispthepnursepd
escribingpwhenpanpisolatedpcellpabsorbspoxygenpandpusespitptoptransformpnutrientsptopenergy?
a. Metabolicpabsorption
b. Communication
c. Secretion
d. Respiration
ANS:p D
Thepcell’spabilityptopabsorbpoxygenpispreferredptopasprespirationpwhilepitspcommunicationpabilitypinvol
vespmaintenancepofpapsteadypdynamicpstate,pmetabolicpabsorptionpprovidespnutrition,pandpsecretionpa
llowspforpthepsynthesizingpofpnewpsubstances.
REF:p p.p2
3. ApeukaryoticpcellpispundergoingpDNApreplication.pInpwhichpregionpofpthepcellpwouldpmostpofpt
hepgeneticpinformationpbepcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleuspCytoplasm
ANS:p C
Thepregionpofpthepcellpthatpcontainspgeneticpmaterial,pincludingpaplargepamountpofpribonucleicpaci
d,pmostpofpthepDNA,pandpDNA-
bindingpproteins,pispthepnucleolus,pwhichpisplocatedpwithinpthepcell’spnucleus.pMitochondriapispa
ssociatedpwithpcellularprespiration,pwhilepribosomesparepinvolvedpwithpproteinpmanufacturing.p
Cytoplasmpispapfluidpfillingpthatpispapcomponentpofpthepcell.
REF:p p.p2
,TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p
Chapter 01: Cellular Biology
p p p
4. Whichpofpthepfollowingpcanpremovepproteinspattachedptopthepcell’spbilayerpbypdissolvingpthepl
ayerpitself?
a. Peripheralpmembranepproteins
b. Integralpmembranepproteins
c. Glycoproteins
d. Cellpadhesionpmolecules
ANS:p B
Proteinspdirectlypattachedptopthepmembranepbilayerpcanpbepremovedpbypthepactionpofpintegralpme
mbranepproteinspthatpdissolvepthepbilayer.pPeripheralpmembranepproteinspresidepatpthepsurfacepw
hilepcellpadhesionpmoleculespareponpthepoutsidepofpthepmembrane.pGlycoproteinpmarkspcellspand
pdoespnotpfloat.
REF:p p.p7
5. Whichpofpthepfollowingpcanpbindptopplasmapmembranepreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathicplipids
d. Ligands
ANS:p D
Ligandspareptheponlypspecificpmoleculespthatpcanpbindpwithpreceptorsponpthepcellpmembrane.
REF:p p.p9
6. Apnursepispreviewingpapreportpfrompappatientpwithpmetastaticpcancer.pWhatpalternationpinpthepe
xtracellularpmatrixpwouldps uNp p oR hIpeTpdG
Ur ptSptpN iagnBo.
siC
spofM
metastaticpcancer?
a. Decreasedpfibronectin
b. Increasedpcollagen
c. Decreasedpelastin
d. Increasedpglycoproteins
ANS:p A
Onlypapreducedpamountpofpfibronectinpispfoundpinpsomeptypespofpcancerouspcells,pallowingpthemp
toptravelporpmetastasize.
REF:p p.p10
7. Whichpformpofpcellpcommunicationpispusedptoprelateptopotherpcellspinpdirectpphysicalpcontact?
a. Cellpjunction
b. Gappjunction
c. Desmosome
d. Tightpjunction
ANS:p A
Cellpjunctionspholdpcellsptogetherpandppermitpmoleculesptoppasspfrompcellptopcell.
Gappjunctionspallowpforpcellularpcommunicationpbetweenpcells.pNeitherpdesmosomespnorptightpjuncti
onsparepassociatedpwithpcellularpcommunication.
REF:p p.p11
,TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p
Chapter 01: Cellular Biology
p p p
8. Pancreaticpbetapcellspsecretepinsulin,pwhichpinhibitspsecretionpofpglucagonpfrompneighboringp
alphapcells.pThispactionpispanpexamplepofpwhichpofpthepfollowingpsignalingptypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:p A
Paracrinepsignalingpinvolvespthepreleasepofplocalpchemicalpmediatorspthatparepquicklyptakenpup,pd
estroyed,porpimmobilized,paspinpthepcasepofpinsulinpandpthepinhibitionpofpthepsecretionpofpglucago
n.pNonepofpthepotherpoptionspinvolvepsignalingpthatpispassociatedpwithpaplocalpchemicalpmediatorp
likepinsulin.
REF:p p.p12
9. Inpcellularpmetabolism,peachpenzymephaspaphighpaffinitypforpa:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:p B
Eachpenzymephaspaphighpaffinitypforpapsubstrate,papspecificpsubstancepconvertedptopapproductpofpt
hepreaction.pCellularpmetabolismpispnotpdependentponpanpattractionpbetweenpanpenzymepandpany
pofpthepremainingpoptions.
REF:p p p.p16
10. Anpathleteprunspapmarathon,pafterpwhichphispmusclespfeelpfatiguedpandpunableptopcontract.pThepat
hletepaskspthepnursepwhypthisphappened.pThepnurse’spresponsepispbasedponpthepknowledgepthatpthe
pproblempispresultpofpapdeficiencypof:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:p C
WhenpATPpispdeficient,pimpairedpmusclepcontractionpresults.pNonepofpthepotherpoptionsparepinvo
lvedpinpmusclepcontraction.
REF:p p.p16
11. WhichpphasepofpcatabolismpproducespthepmostpATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citricpacidpcycle
ANS:p D
WhilepsomepATPpispproducedpduringpthepoxidationpandpglycolysispphases,pmostpofpthepATPpis
, TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p p
Chapter 01: Cellular Biology
p p p
generatedpduringpthepcitricpacidpcycle.pDigestionpdoespnotpproducepanypATP.
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p
Chapter 01: Cellular Biology
p p p
MULTIPLEpCHOICE
1. Apstudentpispobservingpapcellpunderpthepmicroscope.pItpispobservedptophavepsupercoiledpDNAp
withphistones.pWhichpofpthepfollowingpwouldpalsopbepobservedpbypthepstudent?
a. Apsinglepcircularpchromosome
b. Apnucleus
c. Free-floatingpnuclearpmaterial
d. Noporganelles
ANS:p B
Thepcellpdescribedpispapeukaryoticpcell,psopitphasphistonespandpapsupercoiledpDNApwithinpitspnucl
eus;pthus,pthepnucleuspshouldpbepobserved.pApsinglepcircularpchromosomepcalledpapprokaryotepc
ontainspfree-floatingpnuclearpmaterialpbutphaspnoporganelles.
REF:p p.p2
2. Apnursepispinstructingpthepstaffpaboutpcellularpfunctions.pWhichpcellularpfunctionpispthepnursepd
escribingpwhenpanpisolatedpcellpabsorbspoxygenpandpusespitptoptransformpnutrientsptopenergy?
a. Metabolicpabsorption
b. Communication
c. Secretion
d. Respiration
ANS:p D
Thepcell’spabilityptopabsorbpoxygenpispreferredptopasprespirationpwhilepitspcommunicationpabilitypinvol
vespmaintenancepofpapsteadypdynamicpstate,pmetabolicpabsorptionpprovidespnutrition,pandpsecretionpa
llowspforpthepsynthesizingpofpnewpsubstances.
REF:p p.p2
3. ApeukaryoticpcellpispundergoingpDNApreplication.pInpwhichpregionpofpthepcellpwouldpmostpofpt
hepgeneticpinformationpbepcontained?
a. Mitochondria
b. Ribosome
c. Nucleolus
d. NucleuspCytoplasm
ANS:p C
Thepregionpofpthepcellpthatpcontainspgeneticpmaterial,pincludingpaplargepamountpofpribonucleicpaci
d,pmostpofpthepDNA,pandpDNA-
bindingpproteins,pispthepnucleolus,pwhichpisplocatedpwithinpthepcell’spnucleus.pMitochondriapispa
ssociatedpwithpcellularprespiration,pwhilepribosomesparepinvolvedpwithpproteinpmanufacturing.p
Cytoplasmpispapfluidpfillingpthatpispapcomponentpofpthepcell.
REF:p p.p2
,TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p
Chapter 01: Cellular Biology
p p p
4. Whichpofpthepfollowingpcanpremovepproteinspattachedptopthepcell’spbilayerpbypdissolvingpthepl
ayerpitself?
a. Peripheralpmembranepproteins
b. Integralpmembranepproteins
c. Glycoproteins
d. Cellpadhesionpmolecules
ANS:p B
Proteinspdirectlypattachedptopthepmembranepbilayerpcanpbepremovedpbypthepactionpofpintegralpme
mbranepproteinspthatpdissolvepthepbilayer.pPeripheralpmembranepproteinspresidepatpthepsurfacepw
hilepcellpadhesionpmoleculespareponpthepoutsidepofpthepmembrane.pGlycoproteinpmarkspcellspand
pdoespnotpfloat.
REF:p p.p7
5. Whichpofpthepfollowingpcanpbindptopplasmapmembranepreceptors?
a. Oxygen
b. Ribosomes
c. Amphipathicplipids
d. Ligands
ANS:p D
Ligandspareptheponlypspecificpmoleculespthatpcanpbindpwithpreceptorsponpthepcellpmembrane.
REF:p p.p9
6. Apnursepispreviewingpapreportpfrompappatientpwithpmetastaticpcancer.pWhatpalternationpinpthepe
xtracellularpmatrixpwouldps uNp p oR hIpeTpdG
Ur ptSptpN iagnBo.
siC
spofM
metastaticpcancer?
a. Decreasedpfibronectin
b. Increasedpcollagen
c. Decreasedpelastin
d. Increasedpglycoproteins
ANS:p A
Onlypapreducedpamountpofpfibronectinpispfoundpinpsomeptypespofpcancerouspcells,pallowingpthemp
toptravelporpmetastasize.
REF:p p.p10
7. Whichpformpofpcellpcommunicationpispusedptoprelateptopotherpcellspinpdirectpphysicalpcontact?
a. Cellpjunction
b. Gappjunction
c. Desmosome
d. Tightpjunction
ANS:p A
Cellpjunctionspholdpcellsptogetherpandppermitpmoleculesptoppasspfrompcellptopcell.
Gappjunctionspallowpforpcellularpcommunicationpbetweenpcells.pNeitherpdesmosomespnorptightpjuncti
onsparepassociatedpwithpcellularpcommunication.
REF:p p.p11
,TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p
Chapter 01: Cellular Biology
p p p
8. Pancreaticpbetapcellspsecretepinsulin,pwhichpinhibitspsecretionpofpglucagonpfrompneighboringp
alphapcells.pThispactionpispanpexamplepofpwhichpofpthepfollowingpsignalingptypes?
a. Paracrine
b. Autocrine
c. Neurohormonal
d. Hormonal
ANS:p A
Paracrinepsignalingpinvolvespthepreleasepofplocalpchemicalpmediatorspthatparepquicklyptakenpup,pd
estroyed,porpimmobilized,paspinpthepcasepofpinsulinpandpthepinhibitionpofpthepsecretionpofpglucago
n.pNonepofpthepotherpoptionspinvolvepsignalingpthatpispassociatedpwithpaplocalpchemicalpmediatorp
likepinsulin.
REF:p p.p12
9. Inpcellularpmetabolism,peachpenzymephaspaphighpaffinitypforpa:
a. solute.
b. substrate.
c. receptor.
d. ribosome.
ANS:p B
Eachpenzymephaspaphighpaffinitypforpapsubstrate,papspecificpsubstancepconvertedptopapproductpofpt
hepreaction.pCellularpmetabolismpispnotpdependentponpanpattractionpbetweenpanpenzymepandpany
pofpthepremainingpoptions.
REF:p p p.p16
10. Anpathleteprunspapmarathon,pafterpwhichphispmusclespfeelpfatiguedpandpunableptopcontract.pThepat
hletepaskspthepnursepwhypthisphappened.pThepnurse’spresponsepispbasedponpthepknowledgepthatpthe
pproblempispresultpofpapdeficiencypof:
a. GTP
b. AMP
c. ATP
d. GMP
ANS:p C
WhenpATPpispdeficient,pimpairedpmusclepcontractionpresults.pNonepofpthepotherpoptionsparepinvo
lvedpinpmusclepcontraction.
REF:p p.p16
11. WhichpphasepofpcatabolismpproducespthepmostpATP?
a. Digestion
b. Glycolysis
c. Oxidation
d. Citricpacidpcycle
ANS:p D
WhilepsomepATPpispproducedpduringpthepoxidationpandpglycolysispphases,pmostpofpthepATPpis
, TESTpBANKpFORpUNDERSTANDINGpPATHOPHYSIOLOGY
Huether & McCance: Understanding Pathophysiology, 6th Edition
p p p p p p p
Chapter 01: Cellular Biology
p p p
generatedpduringpthepcitricpacidpcycle.pDigestionpdoespnotpproducepanypATP.
