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Agonist/antagonist (mixed) drugs ______ one receptor while _______ the other -
CORRECT ANSWER: stimulate, blocking
Aspirin and nonselective NSAIDs also have ___. - CORRECT ANSWER: anti-platelet
effects
Can antidepressants be discontinued abruptly? - CORRECT ANSWER: No, slow
tapering necessary - antidepressants are not to be discontinued abruptly
Can antidepressants medications trigger a manic episode? - CORRECT ANSWER: Yes
Compare and contrast bulk forming vs hyperosmotic stimulants. - CORRECT ANSWER:
Production of bulk (increased peristalsis) or increased fluid in the lumen (softer stool)
Compare and contrast H2 blockers and PPIs? - CORRECT ANSWER: Compared with
H2 blockers, PPIs suppress gastric acid more strongly, for a longer period. This effect
provides faster symptom relief and faster healing in acid-related diseases
Compared to analgesic effects opioids also have anti______ and anti_______ effects -
CORRECT ANSWER: - Antitussive (cough)
- Antidiarrheal
Explain antiemetics across the lifespan. - CORRECT ANSWER: Children:
- Parents should be taught to call PCP or poison control
,- Should be used with caution in children bc they are more susceptible to adverse
effects
- prochlorphenazine is drug of choice
Adults:
- Often used after surgery or chemotherapy
- Take precautions to avoid CNS effects
- Safety in pregnancy and lactation not established
Older adults:
- More likely to experience adverse effects
- More likely to have renal/hepatic impairment which can effect metabolism and and
excretion of these drugs
- dronabinol should be used with extra cautions
Explain the use of laxatives and antidiarrheal agents across the lifespan. - CORRECT
ANSWER: Children:
- Laxatives should not be used in children routinely
- Should only be used for a short period
- loperamide is the antidiarrheal of choice in children younger than 2
- Precautions should be taken to monitor for electrolyte and fluid disturbances
Adults:
- Should be cautioned not to become dependent on laxatives
- Safety during pregnancy and lactation is not established
Older adults:
- More likely to develop adverse effects of these drugs
,- More likely to have renal/hepatic impairment which could interfere with metabolism
and excretion of these drugs
- Monitor closely
- Should be educated about potential toxic effects
- Drink plenty of fluids, exercise, and get roughage in diet
How are medications absorbed? - CORRECT ANSWER: The vast majority of
medications are taken orally and are broken down within the gastrointestinal tract. Once
the medication arrives, it is broken down by stomach acids before it passes through the
liver and then enters the bloodstream.
How do you treat mild to moderate N/V? - CORRECT ANSWER: OTC drugs and herbs
How do you treat moderate to severe N/V? - CORRECT ANSWER: RX drugs:
- Phenothiazines and non phenothiazines
- Serotonin (5-HT3) receptor blocks
- Substance P/Neurokinin 1 Receptor Antagonists
Miscellaneous:
- Antihistamines and anticholinergics
- Corticosteroids
- Benzodiazepines
- Cannabinoids
How long does it take to see the full effect of buspirone? - CORRECT ANSWER: 4-6
weeks
How often should you take buspirone? - CORRECT ANSWER: Must take daily
, How soon can someone expect antidepressants to begin working? - CORRECT
ANSWER: - Initial improvement with some antidepressants within 7 days; full effects
generally seen in 4-6 weeks
- Physical symptoms will improve prior to seeing the emotional improvement
Is pancrelipase used to treat GERD? - CORRECT ANSWER: No, used for cystic fibrosis
Morphine causes blood vessel ________, smooth muscle ___________, cough
___________, and helps decrease cardiac __________ - CORRECT ANSWER: -
Dilation, relaxation, suppression, preload
- Given to help preserve cardiac muscle during an MI
Most opioids are schedule ___. - CORRECT ANSWER: II
NSAIDs and ASA are widely used to prevent/treat: - CORRECT ANSWER: - Mild to
moderate inflammation
- Mild to moderate pain
- Fever
Opioid agonist drugs ____________ mu and kappa receptors - CORRECT ANSWER:
stimulate
Opioid antagonist drugs _______ mu and kappa receptors - CORRECT ANSWER:
block
Placenta membrane and lactation, how does it relate to distribution? - CORRECT
ANSWER: Not a barrier like the blood-brain barrier, any drug that can pass through a
membrane can pas through the placenta, always ask if a pt is pregnant or lactating