Rang Rang & Dale’s Pharmacology 7th Edition Te
m m m m m m mm
st Bank
m
Questions and Answers
m m
,Rang: Rang & Dale’s
m m m m
Pharmacology, 7th m m
Edition Test Bank m m
Chapter m1:mWhatmismpharmacology?mMULTI
PLEmCHOICE
1. The mmodern mera mof mantimicrobial mchemotherapymoriginated mwithmthemdiscoverymof
1. penicillin
2. arsenical mcompounds
3. quinine
4. sulfonamides
5. calomel
Answermb:marsenical mcompounds
1. Morphine mwasmisolated mfrom mopium mby
1. Paul mEhrlich
2. Gerhard mDomagk
3. Friedrich mSertürner
4. Rudolf mBuchheim
5. HenrymDale
Answermc:mFriedrich mSertürner
1. The muse mof mgeneticminformation mtomguide mthe mchoice mof mdrug mtherapymismcalled
1. pharmacoepidemiology
2. pharmacogenetics
3. biotechnology
4. pharmacogenomics
5. pharmacoeconomics
Answermd:mpharmacogenomics
Chapter m2:mHow mdrugs mact:mgeneralmprinciples mMULTI
PLEmCHOICE
1. The mconcentration mof mamdrug mrequired mto moccupym50mpercentmof mitsmreceptormsitesmis
1. the mconcentration mrequired mtomproduce mthe mmaximum mphysiological meffect
2. directlymproportional mto mthe mdrug’smaffinitymformitsmreceptor
3. inverselymproportional mtomthe mdrug’smaffinitymformitsmreceptor
4. directlymproportional mtomthemdrug’smintrinsicmefficacy
, 5. usuallymdetermined mwith mthe mSchildmequation mA
nswermc:minverselymproportional mtomthemdrug’smaffinitymformitsmrecep
tor
, 1. In mthe mpresence mof mamcompetitive mantagonist,mthe magonistmlog-concentration meffectmcurve mis
1. shifted mtomthe mrightmwithoutmamchange minmslope mormmaximum meffect
2. shifted mtomthe mleftmwithoutmamchange minmslope mormmaximum meffect
3. shifted mtomthe mrightmwith mamdecreased mslope mandmmaximum meffect
4. shifted mtomthe mleftmwith mamdecreased mslope mandmmaximum meffect
5. notmshifted mrightmormleftmbutmshowsma mdecreased mmaximum meffect
Answerma:mshifted mtomthemrightmwithoutmamchange min mslope mormmaximum meffect
1. The mmagnitude mof mthe mresponse mtomamdrug mismrelated mtomthe
1. total mnumbermof mreceptorsmformthe mdrug
2. numbermof mreceptorsmoccupied mbymthe mdrug
3. numbermof mvacantmreceptorsminmthemtissue
4. numbermof mspare mreceptorsminmthemtissue
5. numbermofmphosphorylatedmreceptorsminmthe mtiss
uemAnswermb:mnumbermof mreceptorsmoccupied mbymthemdrug
1. The mSchild mequation mshowsmthatmthemconcentration mratio mofmanmagonistmrequired mto moccupymthemsame mnu
mbermof mreceptorsminmthe mabsence mandmpresence mof mamcompetitive mantagonistmismdetermined mbymthe
1. equilibrium mconstantmof mthe magonist
2. affinitymof mthe magonistmformitsmreceptor
3. equilibrium mconstantmof mthe mantagonist
4. total mnumbermof mavailable mreceptors
5. numbermof mspare mreceptorsminmthemtissue
Answermc:mequilibrium mconstantmof mthe mantagonist
1. Ampartial magonistmismtypicallyma mdrug mthat
1. hasmlowmaffinitymformitsmreceptor
2. can monlymoccupymamsmall mfraction mof mitsmreceptors
3. can monlymproduce mamsubmaximal mresponse
4. requiresmhigh mdosesmto mproduce mammaximal mresponse
5. increasesmthe mnumbermofmsparemrecepto
rsmAnswermc:mcan monlymproduce mamsubmaximal mresponse
1. Amtype mof mdrug mthatmreducesmthe mslope mandmmaximum mresponse mof manmagonistmis
1. amnon-competitive mantagonist
2. amcompetitive mantagonist
3. amphysiologicmantagonist
4. an minverse magonist
5. ampartial magonistmAn
swerma:ma mnon-competitive mantagonist
1. Drugsmthatmform mcovalentmbondsmwith mtheirmreceptorsmare musually
1. reversible mcompetitive mantagonists
2. irreversible mcompetitive m antagonists
3. partial magonists
4. inverse magonists
5. inverse mantagonists
m m m m m m mm
st Bank
m
Questions and Answers
m m
,Rang: Rang & Dale’s
m m m m
Pharmacology, 7th m m
Edition Test Bank m m
Chapter m1:mWhatmismpharmacology?mMULTI
PLEmCHOICE
1. The mmodern mera mof mantimicrobial mchemotherapymoriginated mwithmthemdiscoverymof
1. penicillin
2. arsenical mcompounds
3. quinine
4. sulfonamides
5. calomel
Answermb:marsenical mcompounds
1. Morphine mwasmisolated mfrom mopium mby
1. Paul mEhrlich
2. Gerhard mDomagk
3. Friedrich mSertürner
4. Rudolf mBuchheim
5. HenrymDale
Answermc:mFriedrich mSertürner
1. The muse mof mgeneticminformation mtomguide mthe mchoice mof mdrug mtherapymismcalled
1. pharmacoepidemiology
2. pharmacogenetics
3. biotechnology
4. pharmacogenomics
5. pharmacoeconomics
Answermd:mpharmacogenomics
Chapter m2:mHow mdrugs mact:mgeneralmprinciples mMULTI
PLEmCHOICE
1. The mconcentration mof mamdrug mrequired mto moccupym50mpercentmof mitsmreceptormsitesmis
1. the mconcentration mrequired mtomproduce mthe mmaximum mphysiological meffect
2. directlymproportional mto mthe mdrug’smaffinitymformitsmreceptor
3. inverselymproportional mtomthe mdrug’smaffinitymformitsmreceptor
4. directlymproportional mtomthemdrug’smintrinsicmefficacy
, 5. usuallymdetermined mwith mthe mSchildmequation mA
nswermc:minverselymproportional mtomthemdrug’smaffinitymformitsmrecep
tor
, 1. In mthe mpresence mof mamcompetitive mantagonist,mthe magonistmlog-concentration meffectmcurve mis
1. shifted mtomthe mrightmwithoutmamchange minmslope mormmaximum meffect
2. shifted mtomthe mleftmwithoutmamchange minmslope mormmaximum meffect
3. shifted mtomthe mrightmwith mamdecreased mslope mandmmaximum meffect
4. shifted mtomthe mleftmwith mamdecreased mslope mandmmaximum meffect
5. notmshifted mrightmormleftmbutmshowsma mdecreased mmaximum meffect
Answerma:mshifted mtomthemrightmwithoutmamchange min mslope mormmaximum meffect
1. The mmagnitude mof mthe mresponse mtomamdrug mismrelated mtomthe
1. total mnumbermof mreceptorsmformthe mdrug
2. numbermof mreceptorsmoccupied mbymthe mdrug
3. numbermof mvacantmreceptorsminmthemtissue
4. numbermof mspare mreceptorsminmthemtissue
5. numbermofmphosphorylatedmreceptorsminmthe mtiss
uemAnswermb:mnumbermof mreceptorsmoccupied mbymthemdrug
1. The mSchild mequation mshowsmthatmthemconcentration mratio mofmanmagonistmrequired mto moccupymthemsame mnu
mbermof mreceptorsminmthe mabsence mandmpresence mof mamcompetitive mantagonistmismdetermined mbymthe
1. equilibrium mconstantmof mthe magonist
2. affinitymof mthe magonistmformitsmreceptor
3. equilibrium mconstantmof mthe mantagonist
4. total mnumbermof mavailable mreceptors
5. numbermof mspare mreceptorsminmthemtissue
Answermc:mequilibrium mconstantmof mthe mantagonist
1. Ampartial magonistmismtypicallyma mdrug mthat
1. hasmlowmaffinitymformitsmreceptor
2. can monlymoccupymamsmall mfraction mof mitsmreceptors
3. can monlymproduce mamsubmaximal mresponse
4. requiresmhigh mdosesmto mproduce mammaximal mresponse
5. increasesmthe mnumbermofmsparemrecepto
rsmAnswermc:mcan monlymproduce mamsubmaximal mresponse
1. Amtype mof mdrug mthatmreducesmthe mslope mandmmaximum mresponse mof manmagonistmis
1. amnon-competitive mantagonist
2. amcompetitive mantagonist
3. amphysiologicmantagonist
4. an minverse magonist
5. ampartial magonistmAn
swerma:ma mnon-competitive mantagonist
1. Drugsmthatmform mcovalentmbondsmwith mtheirmreceptorsmare musually
1. reversible mcompetitive mantagonists
2. irreversible mcompetitive m antagonists
3. partial magonists
4. inverse magonists
5. inverse mantagonists
