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NR 547 WEEK 7 EXAM QUESTIONS AND ANSWERS
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Specific ADHD symptoms may arise from prefrontal cortex, executive functioning
abnormalities within circuits in the
_________________, which affect___________________.
Both selective and sustained attention corticostriatal-thalamocortical (CSTC) loop, anxiety
are modulated by the____, the same
loop that is associated with _____________
Which NTMs are associated with Norepinephrine (NE) and Dopamine (DA)
inefficient information processing in the
prefrontal circuits
by selective inhibition of presynaptic norepinephrine reuptake in the prefrontal
How do non-stimulant medications work
cortex and enhancement of norepinephrine neurotransmissioncan help lower
to control ADHD symptoms
distractibility and improve attention, working memory, and impulsivity.
How do stimulant medications work to stimulate the release of NE and DA or boost the firing of associated neurons in
control ADHD symptoms the prefrontal cortex may help improve information processing
Low risk of adverse effects
Available formulations:
Ritalin: available in immediate-release (IR) and extended-release (XR)available in
Methylphenidate
beads that may be sprinkled on food for children who cannot swallow pills
Concerta: biphasic – combined immediate and delayed release in one medication
Daytran: a patch applied in the morning and removed after 9 hours
Available in immediate release and extended release
dexmethylphenidate (Focalin) More potent than Ritalin
High risk of adverse effects
It is available in an orally-disintegrating extended-release formula for children
amphetamine (Adzenys) who cannot swallow pills.
Avoid prescribing when an MAOI has been used within 14 days.
Available in immediate and extended-release formulations
Often dosed in AM (IR or XR) with a PM or PM PRN (IR) dose if medication effects
dextroamphetamine (Adderall)
diminish prior to the end of school, study, or the workday
Most abused and diverted prescription stimulants
Biologically inactive until metabolized by the body (Prodrug)
lisdexamfetamine (Vyvanse) Less abuse and diversion potential than other stimulants
Higher-cost medication
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