MMSC491 Exam 2
1. Which of the following statements is false regarding Most of the inherited
the sources of genetic variation? changes in our DNA arise
because of exposure to ex-
tracellular mutagens, in-
cluding sources of chemi-
cal mutagens
2. With reference to DNA repair, which of the following is Repair of double strand-
false? ed DNA breaks is easier in
cells prior to DNA replica-
tion than after DNA repli-
cation has occurred
3. With reference to imprinting disorders, which of the With the exception of ab-
following is false? normal chromosome seg-
regation, imprinting dis-
orders always result from
a deletion or inactivating
mutation within or span-
ning the imprinted gene
cluster
4. Which of the following describes the non-viral transfer Transfection
of DNA, RNA, and oligonucleotides into human or oth-
er animal cells?
5. Which of the following is an example of a prevention Reduction of susceptibility
treatment? factor
6. Which disorders are more suitable for augmentation Recessive disorders
therapy?
7. Which of the following best describes cytokines?
, MMSC491 Exam 2
Chemical messengers that
help in intracellular signal-
ing
8. Which of the following terms describes the ability to Pluripotent
give rise to all cell types?
9. Which of the following is NOT associated with gene RNA splicing
silencing?
10. What stage of clinical trials includes several hundred Phase II
patients, testing for safety and efficacy?
11. What is the overall observed result of RNA interfer- Long RNA strand
ence?
12. Which of the following is true about siRNA? All of the above
It is 21 base pairs long
It can cause RNA transcripts to be destroyed
Its precursor is ds-RNA
All of the above
13. What is the best disease model choice compared to Primates
humans?
14. Which of the following are components of RNA inter- Dicer
ference? RNA-induced silencing
complex
15. Select the correct description of germ-line and somatic Germ-line gene therapy
cell gene therapies produces a change that
is passed on; somatic cell
gene therapy produces a
1. Which of the following statements is false regarding Most of the inherited
the sources of genetic variation? changes in our DNA arise
because of exposure to ex-
tracellular mutagens, in-
cluding sources of chemi-
cal mutagens
2. With reference to DNA repair, which of the following is Repair of double strand-
false? ed DNA breaks is easier in
cells prior to DNA replica-
tion than after DNA repli-
cation has occurred
3. With reference to imprinting disorders, which of the With the exception of ab-
following is false? normal chromosome seg-
regation, imprinting dis-
orders always result from
a deletion or inactivating
mutation within or span-
ning the imprinted gene
cluster
4. Which of the following describes the non-viral transfer Transfection
of DNA, RNA, and oligonucleotides into human or oth-
er animal cells?
5. Which of the following is an example of a prevention Reduction of susceptibility
treatment? factor
6. Which disorders are more suitable for augmentation Recessive disorders
therapy?
7. Which of the following best describes cytokines?
, MMSC491 Exam 2
Chemical messengers that
help in intracellular signal-
ing
8. Which of the following terms describes the ability to Pluripotent
give rise to all cell types?
9. Which of the following is NOT associated with gene RNA splicing
silencing?
10. What stage of clinical trials includes several hundred Phase II
patients, testing for safety and efficacy?
11. What is the overall observed result of RNA interfer- Long RNA strand
ence?
12. Which of the following is true about siRNA? All of the above
It is 21 base pairs long
It can cause RNA transcripts to be destroyed
Its precursor is ds-RNA
All of the above
13. What is the best disease model choice compared to Primates
humans?
14. Which of the following are components of RNA inter- Dicer
ference? RNA-induced silencing
complex
15. Select the correct description of germ-line and somatic Germ-line gene therapy
cell gene therapies produces a change that
is passed on; somatic cell
gene therapy produces a
