Psychopharmacology - Wilkes
Actual Questions and Answers
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### . What is one form of Naltrexone delivery method limited to
inpatient use?
Answer: Implant.
Explanation: Naltrexone implants are administered in a medical
setting where patients require monitoring as the medication is
released gradually into the body, ensuring adherence and minimizing
relapse after treatment commencement.
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### %. What is the mechanism of action of buprenorphine?
Answer: Mu receptor partial agonist for opioid withdrawal.
Explanation: Buprenorphine acts on the mu-opioid receptors as a
partial agonist, alleviating withdrawal symptoms and cravings while
providing a ceiling effect that reduces the risk of respiratory
depression, making it safer than full agonists.
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,### *. What medication taken too soon after last opioid use increases
the chances of intense withdrawal that comes on very quickly
(precipitated withdrawal)?
Answer: Buprenorphine.
Explanation: Initiating Buprenorphine when significant opioid levels
remain can cause rapid withdrawal due to its partial agonist
properties. This leads users into a challenging situation where
withdrawal symptoms may suddenly intensify, necessitating careful
planning of treatments.
### /. What is the mechanism of action of Naloxone?
Answer: Naloxone is a pure opioid antagonist that competes and
displaces opioids at receptor sites.
Explanation: Naloxone reverses the effects of opioid overdose by
binding to the same mu-opioid receptors in the central nervous system
without activating them, effectively displacing any opioid present. Its
rapid action makes it critical in emergency situations to restore
normal breathing in opioid overdose cases.
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### 0. What medications treat opioid use disorder?
, Answer: Methadone; Buprenorphine; Buprenorphine + Naloxone.
Explanation: These medications facilitate recovery from opioid use
disorder (OUD). Methadone is a long-acting opioid agonist, while
Buprenorphine is a partial agonist that lowers the risk of overdose.
The combination of Buprenorphine with Naloxone is designed to
prevent misuse by causing withdrawal symptoms if the patient tries to
inject it.
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### 7. What medication for opioid use disorder is used with comorbid
pain?
Answer: Buprenorphine + Naloxone.
Explanation: Buprenorphine is a suitable option because it provides
adequate relief for opioid withdrawal and chronic pain through its
partial agonist properties without the full’s opioid effects, hence
reducing the potential for dependency.
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### 9. Inappropriate use of what substance may be due to
uncontrolled pain?