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Complete Pathogenesis.

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This document involves detailed notes on pathogenesis. Essential for all health sciences students.

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Pathogenesis
Pathogenesis is defined as the origination and development of a disease. Insights into
disease etiology and progression, the two major aspects of pathogenesis, are paramount in
the prevention, management and treatment of various diseases. In many cases the
mechanical properties of the tissue or cellular environment contribute to disease
progression or its onset, and this is also true in diseases arising from bacterial infection.
For instance, the ability of a bacteria to invade a cell or tissue, to establish an infection
within the body and to avoid or even exploit the immune response is often dependent on
the bacteria’s ability to manipulate the host cytoskeleton, and exploit various biochemical
pathways that respond to changes in mechanical stimuli.
liver diseases

Your liver is a vital organ that performs hundreds of tasks related to
metabolism, energy storage, and waste filtering. It helps you digest food,
convert it to energy, and store the energy until you need it. It also helps filter
toxic substances out of your bloodstream.

Liver disease is a general term that refers to any condition affecting your liver.
These conditions may develop for different reasons, but they can all damage
your liver and affect its function.

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What are the general symptoms?
Liver disease symptoms vary, depending on the underlying cause. It’s also
possible for someone to have liver disease and not have any symptoms at all.
However, Hepatitis NSW says that a few general symptoms can indicate
some kind of severe liver damage.

These include:

 yellowish skin and eyes, known as jaundice
 pale, bloody, or black stools
 enlarged stomach due to ascites, which may make it uncomfortable to
lie down or eat

,  encephalopathy, a brain issue resulting in marked changes in mood,
sleep, and cognition



What are some common liver
problems?
Many conditions can affect your liver. Here’s a look at some of the main ones.


Hepatitis

Hepatitis is defined as an inflammation of the liver. When that inflammation is
caused by a virus, it’s referred to as viral hepatitis. Hepatitis can cause liver
damage, making it difficult for your liver to function as it should.

Most types of viral hepatitis are contagious, but you can reduce your risk by
getting vaccinated for types A and B and by taking other preventive steps,
including using a condom during sex and not sharing needles.

Five types of hepatitis include:

 Hepatitis A. Hepatitis A is typically spread through contact with
contaminated food or water. Symptoms may clear up without treatment,
but recovery can take a few weeks.
 Hepatitis B. This type of viral hepatitis can be acute (short-term) or
chronic (long-term). It’s spread through bodily fluids, such as blood and
semen. While hepatitis B is treatable, there’s no cure for it. Early
treatment is key to avoiding complications, so it’s best to get regular
screenings if you’re at risk.
 Hepatitis C. Hepatitis C can also be acute or chronic. It’s often spread
through contact with blood from someone with hepatitis C. While it often

, doesn’t cause symptoms in its early stages, it can lead to permanent
liver damage in its later stages.
 Hepatitis D. This is a serious form of hepatitis that only develops in
people with hepatitis B — it can’t be contracted on its own. It can also
be either acute or chronic.
 Hepatitis E. Hepatitis E is usually caused by drinking contaminated
water. Generally, it clears up on its own within a few weeks without any
lasting complications.


Fatty liver disease

Fat buildup in the liver can lead to fatty liver disease.

There are two types of fatty liver disease. These two types can manifest
alone, or they can overlap:

 alcoholic fatty liver disease, which is caused by heavy alcohol
consumption
 nonalcoholic fatty liver disease, which is caused by other factors experts
are still trying to understand

Without management, both types of fatty liver disease can cause liver
damage, leading to cirrhosis and liver failure. Diet and other lifestyle changes
can often improve symptoms and lower your risk of complications.


Autoimmune conditions

Autoimmune conditions involve your immune system mistakenly attacking
healthy cells in your body.

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