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,WGU D236 pathophysiology Exam
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WGU D236 pathophysiology Exam - u u u u
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2022- 2023 u
Patho OA Study Guide u u u
1. What is Starling's Law of Capillary forces? How does this exp
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lain why a nutritionally deficient child would have edema?
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Starling’suLawudescribesuhowufluidsumoveuacrossutheucapillaryumembrane.uThereuare
utwoumajoruopposinguforcesuthatuactutoubalanceueachuother,uhydrostaticupressureu(pushingu
wateruoutuofutheucapillaries)uanduosmoticupressureu(includinguonconticupressure,uwhichupus
hesufluiduintoutheucapillaries).uBothuelectrolytesuanduproteinsu(onconticupressure)uinutheubl
ooduaffectuosmoticupressure,uhighuelectrolyteuanduproteinuconcentrationsuinutheublooduwou
lducauseuwaterutouleaveutheucellsuanduinterstitialuspaceuanduenterutheubloodustreamutoudilut
eutheuhighuconcentrations.uOn,utheuotheruhand,ulowuelectrolyteuanduproteinuconcentrations
u(asuseenuinuaunutritionallyudeficientuchild)uwoulducauseuwaterutouleaveutheucapillariesuandu
enterutheucellsuanduinterstitialufluiduwhichucanuleadutouedema.
2. How does the RAAS (Renin-Angiotensin-
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Aldosterone System) result in increased blood volume and incre
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ased blood pressure?
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Audropuinubloodupressureuisusensedubyutheukidneysubyulowuperfusion,uwhichuinuturnub
eginsutousecreteurenin.uReninuthenutriggersutheuliverutouproduceuangiotensinogen,uwhichuisu
convertedutouAngiotensinuIuinutheulungsuanduthenuangiotensinuIIubyutheuenzymeuAngiotensin
-
convertinguenzymeu(ACE).uAngiotensinuIIustimulatesuperipheraluarterialuvasoconstrictionu
whichuraisesuBP.uAngiotensinuIIuisualsoustimulatingutheuadrenaluglandutoureleaseualdosteron
e,uwhichuactsutouincreaseusodiumuanduwaterureabsorptionuincreasingublooduvolume,uwhileu
alsouincreasedupotassiumusecretionuinuurine.
3. How can hyperkalemia lead to cardiac arrest?
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Normalulevelsuofupotassiumuareubetweenu3.5uandu5.2umEq/dL.uHyperkalemiaurefersut
oupotassiumulevelsuhigheruthatu5.2umEq/dL.uAumajorufunctionuofupotassiumuisutouconductune
rveuimpulsesuinumuscles.u Tooulowu andu muscleu weaknessu occursuandutooumuchucanucauseum
uscleuspasms.uThisuisuespeciallyudangerousuinutheuheartumuscleuanduanuirregularuheartbeatu
canucauseuauheartuattack.
4. The body uses the Protein Buffering System, Phosphate
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Buffering System, and Carbonic Acid-
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Bicarbonate System to regulate and maintain homeostatic pH, w
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hat is the consequence of a pH imbalance?
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ProteinsucontainumanyuacidicuandubasicugrouputhatucanubeuaffectedubyupHuchanges
.uAnyuincreaseuorudecreaseuinubloodupHucanualterutheustructureuofutheuproteinu(denature),u
therebyuaffectinguitsufunctionuasuwell.
5. Describe the laboratory findings associated with metabolic
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acidosis, metabolic alkalosis, respiratory acidosis and respirator
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y alkalosis. (ie relative pH and CO2 levels).
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