NR546 WEEK 2: TEST QUESTIONS WITH ACCURATE
SOLUTIONS
Pharmacokinetics -- Answer ✔✔ the study of what happens to a drug from the time of
administration until the parent drug and all metabolites leave the body
antagonist -- Answer ✔✔ blocks the action of a neurotransmitter
agonists -- Answer ✔✔ fully stimulate G-protein-linked receptors
partial agonists -- Answer ✔✔ stimulate receptors to a lesser degree than an agonist or
natural neurotransmitter
SSRIs, SNRIs, and tricyclic antidepressants increase ________ levels.
___________ do not impact serotonin levels. -- Answer ✔✔ increase serotonin levels.
Benzodiazepines do not impact serotonin levels.
Is nicotine an inducer or an inhibitor of the CYP 1A2 enzyme? -- Answer ✔✔ inducer
Nicotine is an inducer of the CYP 1A2 enzyme. Does the PMHNP anticipate Joshua may
need a higher or lower dose of olanzapine to achieve a therapeutic response? -- Answer
✔✔ Higher
-Nicotine is an inducer of the CYP 1A2 enzyme, so it lowers the concentration of drugs.
Therefore, a higher dose of olanzapine may be needed to control his symptoms.
Why is trazodone not used as a front-line antidepressant -- Answer ✔✔ Its
antidepressant that has a secondary effect of blocking histamine and adrenergic
receptors
-causes sedation and somnolence and as a result
*often used as an adjunct in therapy when a depressed patient has difficulty sleeping
, effect on neurotransmitters and side effects: Selective Serotonin Reuptake Inhibitors
(SSRIs) -- Answer ✔✔ Inhibits the reuptake of serotonin, which can cause nausea,
agitation, headache, and sexual dysfunction
effect on neurotransmitters and side effects: Serotonin and Norepinephrine Reuptake
Inhibitors (SNRIs) -- Answer ✔✔ Inhibits the reuptake of serotonin and norepinephrine,
which can cause nausea, sweating, insomnia, tremors, sexual dysfunction
effect on neurotransmitters and side effects: Tricyclic Antidepressants -- Answer ✔✔ -
Inhibits the reuptake of serotonin and norepinephrine, which can cause sexual
dysfunction
-Blocks norepinephrine receptors, which can cause hypotension and tachycardia
-Blocks histamine receptors, which can cause sedation and weight gain
-Blocks acetylcholine receptors, which can cause dry mouth, constipation, blurred
vision, and urinary retention
effect on neurotransmitters and side effects: Monoamine Oxidase Inhibitors (MAOIs) --
Answer ✔✔ Increases norepinephrine and serotonin by inhibiting the enzyme that
inactivates it, which can cause sedation, dizziness, sexual dysfunction, and hypertensive
crisis
effect on neurotransmitters and side effects: Benzodiazepines -- Answer ✔✔ Increases
the receptor affinity for GABA, which can cause dependence and confusion
effect on neurotransmitters and side effects: Bupropion -- Answer ✔✔ Inhibits the
reuptake of norepinephrine and dopamine, which can cause insomnia, dry mouth,
tremors, and seizures
Pharmacokinetics concepts -- Answer ✔✔ absorption
distribution
metabolism
excretion
Flockhart Table -- Answer ✔✔ drug interactions that are mediated by cytochrome P450
enzymes
SOLUTIONS
Pharmacokinetics -- Answer ✔✔ the study of what happens to a drug from the time of
administration until the parent drug and all metabolites leave the body
antagonist -- Answer ✔✔ blocks the action of a neurotransmitter
agonists -- Answer ✔✔ fully stimulate G-protein-linked receptors
partial agonists -- Answer ✔✔ stimulate receptors to a lesser degree than an agonist or
natural neurotransmitter
SSRIs, SNRIs, and tricyclic antidepressants increase ________ levels.
___________ do not impact serotonin levels. -- Answer ✔✔ increase serotonin levels.
Benzodiazepines do not impact serotonin levels.
Is nicotine an inducer or an inhibitor of the CYP 1A2 enzyme? -- Answer ✔✔ inducer
Nicotine is an inducer of the CYP 1A2 enzyme. Does the PMHNP anticipate Joshua may
need a higher or lower dose of olanzapine to achieve a therapeutic response? -- Answer
✔✔ Higher
-Nicotine is an inducer of the CYP 1A2 enzyme, so it lowers the concentration of drugs.
Therefore, a higher dose of olanzapine may be needed to control his symptoms.
Why is trazodone not used as a front-line antidepressant -- Answer ✔✔ Its
antidepressant that has a secondary effect of blocking histamine and adrenergic
receptors
-causes sedation and somnolence and as a result
*often used as an adjunct in therapy when a depressed patient has difficulty sleeping
, effect on neurotransmitters and side effects: Selective Serotonin Reuptake Inhibitors
(SSRIs) -- Answer ✔✔ Inhibits the reuptake of serotonin, which can cause nausea,
agitation, headache, and sexual dysfunction
effect on neurotransmitters and side effects: Serotonin and Norepinephrine Reuptake
Inhibitors (SNRIs) -- Answer ✔✔ Inhibits the reuptake of serotonin and norepinephrine,
which can cause nausea, sweating, insomnia, tremors, sexual dysfunction
effect on neurotransmitters and side effects: Tricyclic Antidepressants -- Answer ✔✔ -
Inhibits the reuptake of serotonin and norepinephrine, which can cause sexual
dysfunction
-Blocks norepinephrine receptors, which can cause hypotension and tachycardia
-Blocks histamine receptors, which can cause sedation and weight gain
-Blocks acetylcholine receptors, which can cause dry mouth, constipation, blurred
vision, and urinary retention
effect on neurotransmitters and side effects: Monoamine Oxidase Inhibitors (MAOIs) --
Answer ✔✔ Increases norepinephrine and serotonin by inhibiting the enzyme that
inactivates it, which can cause sedation, dizziness, sexual dysfunction, and hypertensive
crisis
effect on neurotransmitters and side effects: Benzodiazepines -- Answer ✔✔ Increases
the receptor affinity for GABA, which can cause dependence and confusion
effect on neurotransmitters and side effects: Bupropion -- Answer ✔✔ Inhibits the
reuptake of norepinephrine and dopamine, which can cause insomnia, dry mouth,
tremors, and seizures
Pharmacokinetics concepts -- Answer ✔✔ absorption
distribution
metabolism
excretion
Flockhart Table -- Answer ✔✔ drug interactions that are mediated by cytochrome P450
enzymes
