CPK Exam 1 - Practice Questions with
complete solutions already passed
The study of the time course of drug absorption, distribution, metabolism, and excretion is
called... - correct answer ✔✔pharmacokinetics
The application of pharmacokinetic principles to the safe and effective therapeutic management
of drugs in an individual patient is known as... - correct answer ✔✔clinical pharmacokinetics
True or false? Since we cannot practically measure drug concentration in specific tissues, we
measure it in the plasma and assume that is concentration is the same as that in the tissue. -
correct answer ✔✔False - the plasma drug concentration is not the same as that in the tissue
but rather is related to the tissue concentration by the volume of distribution
Pharmacodynamics refers to the relationship of drug:
(A) dose to drug concentration in plasma
(B) dose to drug concentration at the receptor site
(C) concentrations to drug effect
(D) dose to drug effect - correct answer ✔✔(C) concentrations to drug effect
True or False? Drug pharmacodynamics are affected by the drug concentration at the site of the
receptor, density of receptors on the target cell surface, mechanism by which a signal is
transmitted into the cell by second messengers, and regulatory factors that control gene
translation and protein production. - correct answer ✔✔True
The EC50 refers to the drug concentration at which:
(A) one-half the maximum response is achieved
, (B) the maximal effect if achieved
(C) tolerance is likely to be observed - correct answer ✔✔(A) one-half the maximum response is
achieved
True or False? The therapeutic range is the range of plasma drug concentrations that clearly
defines optimal drug therapy and where toxic effects cannot occur. - correct answer ✔✔False -
Although the therapeutic range of a drug describes a range of plasma drug concentrations
generally considered safe and effective in a patient population, no absolute boundaries divide
sub therapeutic, therapeutic, and toxic drug concentrations for an individual patient. Both
pharmacodynamic and pharmacokinetic factors influence a patient's response.
True or False? Therapeutic drug concentration monitoring with plasma drug concentration data
assumes that pharmacologic response is related to the drug concentration in plasma. - correct
answer ✔✔True
Factors that cause variability in plasma drug concentrations after the same drug dose is given to
different patients include variations in the:
(A) drug absorption
(B) EC50 of the drug - correct answer ✔✔(A) drug absorption
An example of a situation that would not support therapeutic drug concentration monitoring
with plasma drug concentrations would be one in which:
(A) a wide variation in plasma drug concentrations is achieved in different patients given a
standard drug dose.
(B) the toxic plasma concentration is many times the therapeutic concentration range.
(C) correlation between a drug's plasma concentration and therapeutic response is good. -
correct answer ✔✔(B) the toxic plasma concentration is many times the therapeutic
concentration range
complete solutions already passed
The study of the time course of drug absorption, distribution, metabolism, and excretion is
called... - correct answer ✔✔pharmacokinetics
The application of pharmacokinetic principles to the safe and effective therapeutic management
of drugs in an individual patient is known as... - correct answer ✔✔clinical pharmacokinetics
True or false? Since we cannot practically measure drug concentration in specific tissues, we
measure it in the plasma and assume that is concentration is the same as that in the tissue. -
correct answer ✔✔False - the plasma drug concentration is not the same as that in the tissue
but rather is related to the tissue concentration by the volume of distribution
Pharmacodynamics refers to the relationship of drug:
(A) dose to drug concentration in plasma
(B) dose to drug concentration at the receptor site
(C) concentrations to drug effect
(D) dose to drug effect - correct answer ✔✔(C) concentrations to drug effect
True or False? Drug pharmacodynamics are affected by the drug concentration at the site of the
receptor, density of receptors on the target cell surface, mechanism by which a signal is
transmitted into the cell by second messengers, and regulatory factors that control gene
translation and protein production. - correct answer ✔✔True
The EC50 refers to the drug concentration at which:
(A) one-half the maximum response is achieved
, (B) the maximal effect if achieved
(C) tolerance is likely to be observed - correct answer ✔✔(A) one-half the maximum response is
achieved
True or False? The therapeutic range is the range of plasma drug concentrations that clearly
defines optimal drug therapy and where toxic effects cannot occur. - correct answer ✔✔False -
Although the therapeutic range of a drug describes a range of plasma drug concentrations
generally considered safe and effective in a patient population, no absolute boundaries divide
sub therapeutic, therapeutic, and toxic drug concentrations for an individual patient. Both
pharmacodynamic and pharmacokinetic factors influence a patient's response.
True or False? Therapeutic drug concentration monitoring with plasma drug concentration data
assumes that pharmacologic response is related to the drug concentration in plasma. - correct
answer ✔✔True
Factors that cause variability in plasma drug concentrations after the same drug dose is given to
different patients include variations in the:
(A) drug absorption
(B) EC50 of the drug - correct answer ✔✔(A) drug absorption
An example of a situation that would not support therapeutic drug concentration monitoring
with plasma drug concentrations would be one in which:
(A) a wide variation in plasma drug concentrations is achieved in different patients given a
standard drug dose.
(B) the toxic plasma concentration is many times the therapeutic concentration range.
(C) correlation between a drug's plasma concentration and therapeutic response is good. -
correct answer ✔✔(B) the toxic plasma concentration is many times the therapeutic
concentration range
