CPML-Cardiac Enzymes questions with complete
solutions already passed
1. Cardiac Myocytes Type of myocyte?? branch at one or both ends, contain only one or
occasionally two nuclei, NO ER, held together tightly by
Desmosomes, electrically coupled by gap junctions, contain Intercalated
discs between ends of two cells, Involuntary, striations
2. Cardiac Regulatory proteins found in skeletal and cardiac muscle, 3 subunits,
Tro- Skeletal and cardiac forms distinct - makes it the "gold standard" among
ponins cardiac markers, last longer in bloodstream
Protein linking components in the actin/myosin complex within the
myocardium sarcomere
Cytoplasmic pool and muscular pool
Initial bump in value from cytoplasmic release
Prolonged and more substantial increase from muscular pool release
CPK blood test measures the level of this enzyme released by muscle
3. Creatine after injury or necrosis. useful in evaluating patients with acute
Phos- myocardial infarction
phokinase
MI- high LDH1/LDH2 ratio (opposite of normal serum). Remains high
4. Lactate until about 5 days. Similar to Troponin. However LDH levels don't peak
Dehydro- unitl 2 days after MI.
genase
5. 3 Subtypes of Tro- Troponin I (cTnI)—Inhibits interaction between actin and myosin
ponin
1/
14
, CPML-Cardiac Enzymes questions with complete
solutions already passed
Troponin T (cTnT)—Binds tropomyosin together
6. Uses of Troponin C (cTnC)—Provides binding sites for calcium during contraction
Cardiac
Troponins Ditterentiating cardiac from non-cardiac chest pain
Evaluation and stratification of patients with unstable
angina
2/
14
solutions already passed
1. Cardiac Myocytes Type of myocyte?? branch at one or both ends, contain only one or
occasionally two nuclei, NO ER, held together tightly by
Desmosomes, electrically coupled by gap junctions, contain Intercalated
discs between ends of two cells, Involuntary, striations
2. Cardiac Regulatory proteins found in skeletal and cardiac muscle, 3 subunits,
Tro- Skeletal and cardiac forms distinct - makes it the "gold standard" among
ponins cardiac markers, last longer in bloodstream
Protein linking components in the actin/myosin complex within the
myocardium sarcomere
Cytoplasmic pool and muscular pool
Initial bump in value from cytoplasmic release
Prolonged and more substantial increase from muscular pool release
CPK blood test measures the level of this enzyme released by muscle
3. Creatine after injury or necrosis. useful in evaluating patients with acute
Phos- myocardial infarction
phokinase
MI- high LDH1/LDH2 ratio (opposite of normal serum). Remains high
4. Lactate until about 5 days. Similar to Troponin. However LDH levels don't peak
Dehydro- unitl 2 days after MI.
genase
5. 3 Subtypes of Tro- Troponin I (cTnI)—Inhibits interaction between actin and myosin
ponin
1/
14
, CPML-Cardiac Enzymes questions with complete
solutions already passed
Troponin T (cTnT)—Binds tropomyosin together
6. Uses of Troponin C (cTnC)—Provides binding sites for calcium during contraction
Cardiac
Troponins Ditterentiating cardiac from non-cardiac chest pain
Evaluation and stratification of patients with unstable
angina
2/
14
