GLYCOLYSIS & GLUCONEOGENESIS
Glucose
Pyrovate Pyruvate Glucose
>
-
>
-
Pi
G6Pase ATP
Glucose
Glycolysis -
Reg
tions
-
& Muscle >
Energy Charge
·
Hexokinase -
ADP
H20 Feedback Liver [Glucose] &
-
(building blocks
·
>
-
inhibition
Glucose-6-Phosphate [High] promote gluconeogenesis &
turn down
glycolysis
Phosphoglucose isomerase
Liver
Pi
Fructose-6-phosphate Allosteric
High [Citrate]
ATP
F-1, 6-BPase
inhibition
PFK-1 ? (Rate limiting
-
ADP
H20
Cytoplasm
Feedback
F -
1 6 BP
,
-
inhibition
Aldolase + TPI
X2 net reaction per
glucose
DHAP-GAP
=
GAPDH
1 3-BPE
,
ADP
ATP Phosphoglycerate Kinase
3-BPG
Phosphoglycerate Mutase
Gluconeogenesis 2- BPG
Counteracting Enzymes
Glu
Encase
ADP + CO2
·
PEPCK
Glu
>
-
Pyruvate Kinase
ATP
PEP
F 1,6 BP
- -
·
FGBPase- > PF1
Feedforwardas
PEPCK ADP Glu
Kinase !
·
G-6-Pase- > Hexoinase
ATP Pyruvate
Oxaloacetate Allostea
Oxidized
Pyruvate High [ATP] & [Alanine]
Pyruvate
boxylase
Pyruvate Carboxylase >
-
G exclusive
.
Reduced CO2
Malate Oxaloacetate
Glycolysis net yield (per glucose moleale
Mitochondria ·
2ATP 2 NADH & 2
,
pyruvate
, FERMENTATION
Lactate Fermentation
(Eukaryotic/Muscles
Reduction of lactate to
by NADT
·
NADH to
pyruvate regenerate
Glycolysis
+
NAD
NADH
Lactate
Pyruvate Lactatedh
Ethanol Fermentation (Yeast
Decarboxylation + reduction of ethanol for NADT
·
pyruvate
to
regeneration .
GAP
i
1 3-13PG
,
NADH+H+ NADT
H
+ CO2
Pyruvate pyruvate Decorbogase
Acetaldehyde Marion
Ethanol
Glucose
Pyrovate Pyruvate Glucose
>
-
>
-
Pi
G6Pase ATP
Glucose
Glycolysis -
Reg
tions
-
& Muscle >
Energy Charge
·
Hexokinase -
ADP
H20 Feedback Liver [Glucose] &
-
(building blocks
·
>
-
inhibition
Glucose-6-Phosphate [High] promote gluconeogenesis &
turn down
glycolysis
Phosphoglucose isomerase
Liver
Pi
Fructose-6-phosphate Allosteric
High [Citrate]
ATP
F-1, 6-BPase
inhibition
PFK-1 ? (Rate limiting
-
ADP
H20
Cytoplasm
Feedback
F -
1 6 BP
,
-
inhibition
Aldolase + TPI
X2 net reaction per
glucose
DHAP-GAP
=
GAPDH
1 3-BPE
,
ADP
ATP Phosphoglycerate Kinase
3-BPG
Phosphoglycerate Mutase
Gluconeogenesis 2- BPG
Counteracting Enzymes
Glu
Encase
ADP + CO2
·
PEPCK
Glu
>
-
Pyruvate Kinase
ATP
PEP
F 1,6 BP
- -
·
FGBPase- > PF1
Feedforwardas
PEPCK ADP Glu
Kinase !
·
G-6-Pase- > Hexoinase
ATP Pyruvate
Oxaloacetate Allostea
Oxidized
Pyruvate High [ATP] & [Alanine]
Pyruvate
boxylase
Pyruvate Carboxylase >
-
G exclusive
.
Reduced CO2
Malate Oxaloacetate
Glycolysis net yield (per glucose moleale
Mitochondria ·
2ATP 2 NADH & 2
,
pyruvate
, FERMENTATION
Lactate Fermentation
(Eukaryotic/Muscles
Reduction of lactate to
by NADT
·
NADH to
pyruvate regenerate
Glycolysis
+
NAD
NADH
Lactate
Pyruvate Lactatedh
Ethanol Fermentation (Yeast
Decarboxylation + reduction of ethanol for NADT
·
pyruvate
to
regeneration .
GAP
i
1 3-13PG
,
NADH+H+ NADT
H
+ CO2
Pyruvate pyruvate Decorbogase
Acetaldehyde Marion
Ethanol
