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1. Structure of
fascia covers the whole muscle, the muscle is broken up into fascicles made
a skeletal
up of many muscle fibers, each muscle fiber is made up of myofibrils
muscle
contained actin and myosin as the basic unit of contraction for the
muscle
2. dynein and
ki- nesin Motor proteins that control organelle and vesicle movement along
microtubules
3. cardiac muscle i nucleus, intercalated discs connect the fibers
4. smooth muscle No striations from sarcomeres, small individual cells in the GI tract, vessel
etc
5. two systems microtubules with dynein and kinesin and actin with myosin moving along
a cell uses + intermediate filament is the smallest of the cytoskeleton types, not a
for
cellular highway
movement
6. myosin direction + directed
7. kinesin direction + directed
8. dynein direction - directed
9. myosin structure head binds actin and creates movement with power stroke, tail binds
with others to form filaments, neck allows movement
many types of myosin heads and ATPases
2 light chains in a dimer, bind tails to form double ended myosin that
goes between the thin filaments of the sarcomere
10. muscle types skeletal muscle is the only voluntary type
cardiac and skeletal are striated
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nucleation: skeletal has many, cardiac and smooth single
connection: fused tubes in skeletal, intercalated discs in cardiac, single in
smooth
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11. skeletal myoblast proliferate
muscle primary fiber formed in the start of ditterentiation, has multiple nuclei
developmen
secondary fiber forms and nuclei move to the edges of the cell to make
t
room for machinery
mature fiber forms and is striated and multi-nucleated
in males only, mutation causes holes to form in the membrane during
contrac- tions, destroying Ca gradient and causing damaging
12. muscular
dystro- phy contractions
13. thin filament made of actin, surrounded by tropomyosin and regulated by troponins
tropomyosin covers the actin binding site until uncovered by the troponins
to generate muscle contraction
14. what induces calcium release from the SR induces contraction, binds troponin C
muscle which moves tropomyosin and allows myosin to bind actin and
contrac- tion perform a power stroke
and how?
15. power stroke starts with myosin binding actin head, ADP and P are already there
release of ADP and P causes power stroke and myosin head rotates to
move down the filament
ATP binds to release the myosin head and is hydrolyzed to recock the head
for the next power stroke
16. how is alpha motor neuron gets AP and release ACh into the NMJ, triggers
calcium acetylcholine receptors and release Na into the fiber, triggering an AP
release that travels down the sarcolemma into the t tubules, triggers DHPR which
regulat- ed?
is connected to RYR, ryr opens channels in SR releasing some Ca, rest of
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Ca channels are Ca
activated and open in
response, generating
contraction