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Levodopa MOA - ✔✔Reduces symptoms by increasing dopamine synthesis in the
striatum
Levodopa Adverse Effects - ✔✔Nausea and Vomiting
Levodopa Absorption - ✔✔Food delays absorption, no high protein foods
Carbidopa MOA - ✔✔Carbidopa is used to enhance the effects of levodopa
Benztropine Uses - ✔✔Reduce tremor and possibly rigidity
Donepezil MOA - ✔✔Cholinesterase inhibitor, prevents breakdown of acetylcholine
Donepezil therapeutic benefits of drugs - ✔✔Helps slow progression of AD
Donepezil dosing - ✔✔PO only
5 mg once daily x 4 - 6 weeks then
Increase to 10 mg daily
Interferon Beta MOA - ✔✔immunomodulators, helps protect nerve cells
Interferon Beta Uses - ✔✔Reduces the frequency and severity of parkinson attacks
Reduces the number and size of lesions detectable with magnetic resonance imaging
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, Delays progression of disability
Interferon Beta side/adverse effects - ✔✔Flu-like reactions
Hepatotoxicity
Myelosuppression
Injection-site reactions
Depression
Suicidal thoughts
Neutralizing antibodies
Drug interactions
Interferon Beta nursing management - ✔✔Allergic reactions
Mitoxantrone MOA - ✔✔Binds with DNA and inhibits topoisomerase
Mitoxantrone nursing assesment - ✔✔Perform complete blood counts at baseline and
before each dose
Perform liver function tests at baseline and before each dose
Perform a pregnancy test before each dose
Determine left ventricular ejection fraction
Mitoxantrone dosing - ✔✔12 mg IV infusion every three months
Phenytoin MOA - ✔✔Selective inhibition of sodium channels
Phenytoin Patient teaching about taking/stopping drug - ✔✔must stop slowly or can
cause seizures,
Phenytoin S/E and patient teaching - ✔✔Birth control
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