Module 12: Alterations of Erythrocyte Function Questions & Answers Exam Review 2025

Module 12: Alterations of Erythrocyte Function Questions & Answers Exam Review 2025 Vaso-occlusive crisis in sickle cell disease manifests with which of the following symptoms? A) Pain B) Pancytopenia C) Splenomegaly D) Hypotension - ANS-A) Pain Answer Feedback: Ischemia from the obstruction of capillaries by malformed erythrocytes results in pain. The reticulocyte count in iron deficiency, vitamin B12, and folate deficiency is: A) increased. B) decreased. C) absent. D) impossible to measure. - ANS-B) decreased Answer Feedback: Any nutrient deficiency anemia results in the decreased bone marrow production of erythrocytes and therefore is reflected in a decreased reticulocyte count. Clinical manifestations unique to vitamin B12 anemia (i.e., usually absent in other types of anemia) include: A) fatigue, dyspnea on exertion, and pale skin. B) palpitations, chest pain, and signs of heart failure. C) dizziness, headaches, and nausea. D) paresthesias, muscle weakness, and ataxia. - ANS-D) paresthesias, muscle weakness, and ataxia.` Answer Feedback: Neurological complications caused by vitamin B12 deficiency include paresthesias, muscle weakness, and ataxia. These symptoms are related to demyelination of peripheral neurons. All of the following are reasons why chronic infections (HIV disease, hepatitis), rheumatological diseases, and malignancies result in anemia of chronic inflammation (anemia of chronic disease), except: