PATH 3610 UNIT 7: NEOPLASIA:
TEST QUESTIONS WITH CORRECT
ANSWERS
1) In our society, few diseases are as feared as?
2) Statistics Canada has estimated that one in two Canadians will
develop?
3) We know that the breast, colorectal, lung and prostate cancer are?
-- Answer ✔✔ 1) cancer
2) cancer in their lifetime, and one in 4 will die from cancer
3) the most common types of cancer (excluding non-melanoma skin
cancer) in women and men
1) Cancer can have devastating?
2) The term neoplasia refers to?
3) The result of these abnormalities is the development of? -- Answer
✔✔ 1) effects
2) an abnormality in cellular differentiation, maturation and control of
growth, it can be considered excessive and disorganized cell or tissue
growth that is unresponsive to normal growth control mechanisms
3) a tumour or neoplasm, a mass of abnormal tissue
,1) There are a number of disturbances of growth, differentiation and
maturation which are not?
2) Many of the body's cells retain the ability to?
3) This growth and differentiation is controlled, such that? -- Answer
✔✔ 1) neoplastic, though one of them, dysplasia, is recognized as a
premalignant lesion
2) grow, divide, and differentiate throughout life
3) the normal structure of a particular tissue is maintained
1) For the normal structure of a tissue to be maintained, the rate of cell
proliferation must balance with?
2) If there is a discrepancy between these rates, then the tissue will
become?
3) Disturbances in growth can lead to either? -- Answer ✔✔ 1) the rate
of differentiation (leading to cell death)
2) abnormal, both at the gross and histologic level
3) an increase or a decrease in the mass of the affected tissue; many
of these changes are initiated as a cellular response or adaptation to
injury
1) Hyperplasia is?
2) Tissues showing pathologic hyperplasia are at increased risk of?
3) What does hyperplasia refer to? -- Answer ✔✔ 1) the main
mechanism causing increasing size in tissues consisting of labile and
stable cell types; it results when the cells of a tissue are stimulated to
undergo mitosis
2) neoplastic transformation (becoming cancerous)
,3) -increased tissue differentiated cell numbers in response to
hormones and other growth factors (stimulating the cells to undergo
mitosis)
-occurs in tissues whose cells are able to divide or contain abundant
tissue stem cells, i.e. cell populations capable of replication
-It may occur concurrently with hypertrophy and often in response to
the same stimuli
1) Physiologic hyperplasia includes both hormonal and compensatory
hyperplasia.
Define hormonal hyperplasia.
Define compensatory hyperplasia
2) Pathologic hyperplasia is a nonphysiologic response. Most forms of
pathologic hyperplasia result from what?
3) Give two examples of pathological hyperplasia. -- Answer ✔✔ 1) -
hormonal: exemplified by the proliferation of the glandular epithelium
of the female breast at puberty/during pregnancy.
-compensatory: in which residual tissue grows after removal or loss of
part of an organ or tissue (possibly from disease)
2) -excessive hormonal or growth factor stimulation
3) -After a normal menstrual period there is a burst of uterine epithelial
proliferation that is normally tightly regulated by stimulation through
pituitary hormones and ovarian estrogen and by inhibition through
progesterone. However, a disturbed balance between estrogen and
progesterone causes endometrial hyperplasia, which is a common
cause of abnormal menstrual bleeding
-response of connective tissue cells (proliferating fibroblasts) in wound-
healing (growth factors produced by WBC, respond to injury)
, 1) What does hypertrophy refer to?
2) Hypertrophy is the only method of adaptation that can occur in?
3) For example, the cells of the heart (myocardium) will hypertrophy in
response to? -- Answer ✔✔ 1) increase in cell size
2) tissues made up of permanent cells, in which an increased
functional demand cannot be met by cell multiplication
3) an increased metabolic demand
1) During hypertrophy, there is an increase in?
2) Skeletal muscle can only respond hypertrophy of?
3) Both hyperplasia and hypertrophy can be physiologic, occurring in
response to? -- Answer ✔✔ 1) the amount of cytoplasm and the
numbers of cytoplasmic organelles
2) individual muscle cells
3) an increased demand
1) Both hyperplasia and hypertrophy are reversible:
2) Hypertrophy and hyperplasia can also occur together, leading to?
3) Hyperplasia and hypertrophy can also be pathologic, occurring
without? -- Answer ✔✔ 1) if the demand is removed, tissues will return
to normal
2) organ enlargement (ie physiologic enlargement of the pregnant
uterus)
3) an increased functional demand
TEST QUESTIONS WITH CORRECT
ANSWERS
1) In our society, few diseases are as feared as?
2) Statistics Canada has estimated that one in two Canadians will
develop?
3) We know that the breast, colorectal, lung and prostate cancer are?
-- Answer ✔✔ 1) cancer
2) cancer in their lifetime, and one in 4 will die from cancer
3) the most common types of cancer (excluding non-melanoma skin
cancer) in women and men
1) Cancer can have devastating?
2) The term neoplasia refers to?
3) The result of these abnormalities is the development of? -- Answer
✔✔ 1) effects
2) an abnormality in cellular differentiation, maturation and control of
growth, it can be considered excessive and disorganized cell or tissue
growth that is unresponsive to normal growth control mechanisms
3) a tumour or neoplasm, a mass of abnormal tissue
,1) There are a number of disturbances of growth, differentiation and
maturation which are not?
2) Many of the body's cells retain the ability to?
3) This growth and differentiation is controlled, such that? -- Answer
✔✔ 1) neoplastic, though one of them, dysplasia, is recognized as a
premalignant lesion
2) grow, divide, and differentiate throughout life
3) the normal structure of a particular tissue is maintained
1) For the normal structure of a tissue to be maintained, the rate of cell
proliferation must balance with?
2) If there is a discrepancy between these rates, then the tissue will
become?
3) Disturbances in growth can lead to either? -- Answer ✔✔ 1) the rate
of differentiation (leading to cell death)
2) abnormal, both at the gross and histologic level
3) an increase or a decrease in the mass of the affected tissue; many
of these changes are initiated as a cellular response or adaptation to
injury
1) Hyperplasia is?
2) Tissues showing pathologic hyperplasia are at increased risk of?
3) What does hyperplasia refer to? -- Answer ✔✔ 1) the main
mechanism causing increasing size in tissues consisting of labile and
stable cell types; it results when the cells of a tissue are stimulated to
undergo mitosis
2) neoplastic transformation (becoming cancerous)
,3) -increased tissue differentiated cell numbers in response to
hormones and other growth factors (stimulating the cells to undergo
mitosis)
-occurs in tissues whose cells are able to divide or contain abundant
tissue stem cells, i.e. cell populations capable of replication
-It may occur concurrently with hypertrophy and often in response to
the same stimuli
1) Physiologic hyperplasia includes both hormonal and compensatory
hyperplasia.
Define hormonal hyperplasia.
Define compensatory hyperplasia
2) Pathologic hyperplasia is a nonphysiologic response. Most forms of
pathologic hyperplasia result from what?
3) Give two examples of pathological hyperplasia. -- Answer ✔✔ 1) -
hormonal: exemplified by the proliferation of the glandular epithelium
of the female breast at puberty/during pregnancy.
-compensatory: in which residual tissue grows after removal or loss of
part of an organ or tissue (possibly from disease)
2) -excessive hormonal or growth factor stimulation
3) -After a normal menstrual period there is a burst of uterine epithelial
proliferation that is normally tightly regulated by stimulation through
pituitary hormones and ovarian estrogen and by inhibition through
progesterone. However, a disturbed balance between estrogen and
progesterone causes endometrial hyperplasia, which is a common
cause of abnormal menstrual bleeding
-response of connective tissue cells (proliferating fibroblasts) in wound-
healing (growth factors produced by WBC, respond to injury)
, 1) What does hypertrophy refer to?
2) Hypertrophy is the only method of adaptation that can occur in?
3) For example, the cells of the heart (myocardium) will hypertrophy in
response to? -- Answer ✔✔ 1) increase in cell size
2) tissues made up of permanent cells, in which an increased
functional demand cannot be met by cell multiplication
3) an increased metabolic demand
1) During hypertrophy, there is an increase in?
2) Skeletal muscle can only respond hypertrophy of?
3) Both hyperplasia and hypertrophy can be physiologic, occurring in
response to? -- Answer ✔✔ 1) the amount of cytoplasm and the
numbers of cytoplasmic organelles
2) individual muscle cells
3) an increased demand
1) Both hyperplasia and hypertrophy are reversible:
2) Hypertrophy and hyperplasia can also occur together, leading to?
3) Hyperplasia and hypertrophy can also be pathologic, occurring
without? -- Answer ✔✔ 1) if the demand is removed, tissues will return
to normal
2) organ enlargement (ie physiologic enlargement of the pregnant
uterus)
3) an increased functional demand
