NR546 WEEK 2 TEST YOUR KNOWLEDGE QUESTIONS WITH CORRECT ANSWERS.

NR546 WEEK 2: TEST YOUR
KNOWLEDGE QUESTIONS WITH
CORRECT ANSWERS

Pharmacokinetics - ANSWER: the study of what happens to a drug from the time of nn nn nn nn nn nn nn nn nn nn nn nn nn nn



administration until the parent drug and all metabolites leave the body
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Pharmacokinetics concepts - ANSWER: absorption nn nn nn nn



distribution
metabolism
excretion

Flockhart Table - ANSWER: drug interactions that are mediated by cytochrome P450
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enzymes
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comprehensive list of drugs and the interactions related to the cytochrome P450
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system
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client factors that impact the effect of psychotropic medications - ANSWER: -age
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-diet
-smoking status nn



-other prescribed medications
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-over-the-counter medications nn




*all impact drug metabolism
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Neurotransmitters - ANSWER: chemicals released by neurons to send communication nn nn nn nn nn nn nn nn nn



across synaptic clefts to other neurons
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-impact human emotion and behavior
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Many psychiatric disorders and client symptoms occur from an excess, deficiency, or
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imbalance of _________ - ANSWER: neurotransmitters
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Neurotransmission: - ANSWER: the chemical transmission of information between nn nn nn nn nn nn nn nn



neurons and their target cells
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-the chemicals, or neurotransmitters, are released from their transport vesicles to bind
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with receptor sites to perform their duties, which are excitatory or inhibitory
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-neurotransmitter then either returned and stored for future use (reuptake) or
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inactivated and dissolved by enzymes
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, Excitatory neurotransmitters: - ANSWER: increase the likelihood that the neuron will
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fire an action potential
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inhibitory neurotransmitters: - ANSWER: decrease the likelihood that a neuron will fire
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an action
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neurotransmitters that most impact mental health can be classified into four major nn nn nn nn nn nn nn nn nn nn nn



categories: - ANSWER: cholinergics
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-acetylcholine

monoamines
-norepinephrine, dopamine, serotonin, histamine nn nn nn




amino acids nn



-gamma- amino-butyric acid and glutamate
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neuropeptides

Inhibitors: VISA CKGQ - ANSWER: Valproate
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Isoniazid
Sulfonamides
Amiodarone
Chloramphenicol
Ketoconazole
Grapefruit Juice nn



Quinidine

-decrease medication metabolism nn nn




Inducers: CRAP GPS - ANSWER: Carbamazepine
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Rifampin
Alcohol
Phenytoin
Griseofulvin
Phenobarbital
Sulfonylureas

-increase medication metabolism nn nn




neurotransmitters that may be responsible for a client's symptoms of depression - nn nn nn nn nn nn nn nn nn nn nn



ANSWER: Imbalanced levels of acetylcholine, norepinephrine, serotonin, histamine,
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or glutamate can contribute to symptoms of depression
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client who is a poor metabolizer: - ANSWER: has a lower concentration of the
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necessary enzyme to metabolize a drug, which results in higher blood concentrations
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of the drug.
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