BIOD331 Module 2 Neoplasia
Comprehensive Final Test (Qns & Ans)
2025
Question 1 (Multiple Choice)
Question:
Which of the following features best distinguishes a malignant
neoplasm from a benign tumor?
A) Slow growth rate
B) Well-circumscribed borders
C) Invasive behavior and metastasis
D) Uniform cellular appearance
Correct ANS:
C) Invasive behavior and metastasis
Rationale:
©2025
,While benign tumors are usually slow-growing, well-
circumscribed, and composed of uniform cells, the hallmark of
malignancy is the ability to invade surrounding tissues and
migrate to distant sites (metastasis). These features reflect the loss
of normal regulatory controls.
---
Question 2 (Fill in the Blank)
Question:
The process by which normal cells accumulate genetic and
epigenetic changes that transform them into neoplastic cells is
known as ________ .
Correct ANS:
carcinogenesis
Rationale:
Carcinogenesis refers to the multi-step process in which normal
cells undergo genetic mutations and epigenetic alterations that
lead to uncontrolled proliferation and the development of cancer.
This process involves initiation, promotion, and progression
stages.
©2025
,---
Question 3 (True/False)
Question:
True/False: Benign tumors are capable of metastasizing and
invading adjacent tissues.
Correct ANS:
False
Rationale:
Benign tumors are non-invasive and remain localized; they do not
metastasize. In contrast, malignant tumors possess the ability to
invade nearby structures and spread to distant sites through
metastasis.
---
Question 4 (Multiple Response)
Question:
Select all features that are recognized as hallmarks of cancer:
A) Self-sufficiency in growth signals
©2025
, B) Insensitivity to anti-growth signals
C) Evasion of apoptosis
D) Sustained angiogenesis
E) Tissue invasion and metastasis
Correct ANS:
A, B, C, D, E
Rationale:
The hallmarks of cancer include a series of biological capabilities
acquired during tumor development such as self-sufficiency in
growth signals, insensitivity to inhibitory signals, evading
programmed cell death (apoptosis), inducing angiogenesis to
supply nutrients, and the ability to invade and metastasize.
---
Question 5 (Multiple Choice)
Question:
A patient presents with a family history of colon cancer and
multiple colonic adenomas. Which gene mutation is most
commonly associated with hereditary colorectal cancer in this
setting?
©2025
Comprehensive Final Test (Qns & Ans)
2025
Question 1 (Multiple Choice)
Question:
Which of the following features best distinguishes a malignant
neoplasm from a benign tumor?
A) Slow growth rate
B) Well-circumscribed borders
C) Invasive behavior and metastasis
D) Uniform cellular appearance
Correct ANS:
C) Invasive behavior and metastasis
Rationale:
©2025
,While benign tumors are usually slow-growing, well-
circumscribed, and composed of uniform cells, the hallmark of
malignancy is the ability to invade surrounding tissues and
migrate to distant sites (metastasis). These features reflect the loss
of normal regulatory controls.
---
Question 2 (Fill in the Blank)
Question:
The process by which normal cells accumulate genetic and
epigenetic changes that transform them into neoplastic cells is
known as ________ .
Correct ANS:
carcinogenesis
Rationale:
Carcinogenesis refers to the multi-step process in which normal
cells undergo genetic mutations and epigenetic alterations that
lead to uncontrolled proliferation and the development of cancer.
This process involves initiation, promotion, and progression
stages.
©2025
,---
Question 3 (True/False)
Question:
True/False: Benign tumors are capable of metastasizing and
invading adjacent tissues.
Correct ANS:
False
Rationale:
Benign tumors are non-invasive and remain localized; they do not
metastasize. In contrast, malignant tumors possess the ability to
invade nearby structures and spread to distant sites through
metastasis.
---
Question 4 (Multiple Response)
Question:
Select all features that are recognized as hallmarks of cancer:
A) Self-sufficiency in growth signals
©2025
, B) Insensitivity to anti-growth signals
C) Evasion of apoptosis
D) Sustained angiogenesis
E) Tissue invasion and metastasis
Correct ANS:
A, B, C, D, E
Rationale:
The hallmarks of cancer include a series of biological capabilities
acquired during tumor development such as self-sufficiency in
growth signals, insensitivity to inhibitory signals, evading
programmed cell death (apoptosis), inducing angiogenesis to
supply nutrients, and the ability to invade and metastasize.
---
Question 5 (Multiple Choice)
Question:
A patient presents with a family history of colon cancer and
multiple colonic adenomas. Which gene mutation is most
commonly associated with hereditary colorectal cancer in this
setting?
©2025
