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Kawasaki Disease description
an acute, afebrile, immune mediated self limited disease of young children
characterized by vasculitis that leads to coronary artery aneurysms, especially in
medium sized vessels, with multi system involvement
Kawasaki Disease aka
Mucocutaneous lymph node syndrome
Kawasaki Disease vasculopathy 3 linked processes
-necrotizing arteritis
-subacute/chronic vasculitis, resulting in pericarditis and myocarditis around coronary
arteries
-luminal myofibroplastic proliferative may lead to decrease in lumen diameter resulting
in stenotic vessels
Kawasaki Disease risk factors
-History of KD increases risk of recurrence
-Siblings of Japanese parents
-<5 years old
-Asian decent: Japanese or Korean
Kawasaki Disease Acute phase (1-2 weeks) Assessment Findings
-High fever for a least 5 that is unresponsive to ABX
-Oral mucosal lesions that may last 1-2 weeks
-Perineal rash
-Nontender cervical adenopathy
-Painful rash and edema to feet
-Possible MI
Kawasaki Disease Diagnostic criteria require 5 days of fever and 4 of the
following
-Edema or erythema of the hands and feet
-Conjunctival injection
-Cervical lymphadenopathy
, -Rash (nonvesicular an polymorphous) maculopapular, diffuse erythroderma, or
erythema multiform like
-Exudative pharyngitis with diffuse oral erythema, strawberry tongue, crusting/cracking
of lips and mouth
Kawasaki Disease Subacute phase (2-8 weeks after onset) Assessment Findings
-Desquamation of palms, feet, periungual area, perineal area, coronary artery
aneurysm, joint aches and pain
-Acute MI
-Pancarditis
-Diarrhea, jaundice, hepatosplenomegaly
-Aseptic meningitis
-Sterile pyuria
-Platelet count may rise to 10000000
Kawasaki Disease Convalescent phase (6-8 weeks after onset) Assessment
Findings
Symptoms usually resolve and sedimentation rate returns to normal
Kawasaki Disease nonspecific S/S
-Beau's lines on nails
-Cough
-Rhinorrhea
-Pulmonary infiltrate
-Abdominal pain
-Hydrops of gallbladder
-Paralytic ileus
-Facial palsy
Kawasaki Disease lab findings
-CBC leukocytosis
-Lymphocytes usually drop in acute phase
-Anemia: normocytic and normochormic
-Elevated platelet count
-ESR >100