BasicgandgClinicalgPharmacologyg14thgEditiongKatzunggTrevorgTestg Bank
Chapterg1.gIntroduction:gThegNaturegofgDrugsg&gDruggDevelopmentg&gRegulation
1.
Agnursegworkinggingradiologygadministersgiodinegtogagpatientgwhogisghavi
nggagcomputedgtomographyg(CT)gscan.gThegnursegworkinggongthegoncologyg
unitgadministersgchemotherapygtogpatientsgwhoghavegcancer.gAtgthegPublicgH
ealthgDepartment,gagnursegadministersgagmeasles-mumps-
rubellag(MMR)gvaccinegtogag14-month-
oldgchildgasgagroutinegimmunization.gWhichgbranchgofgpharmacologygbestgde
scribesgthegactionsgofgallgthreeg nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacologygisgthegstudygofgthegbiologicgeffectsgofgchemicals.gNursesgaregi
nvolvedgwithgclinicalgpharmacologygorgpharmacotherapeutics,gwhichgisgagbr
anchgofgpharmacologygthatgdealsgwithgthegusesgofgdrugsgtogtreat,gprevent,gan
dgdiagnosegdisease.gThegradiologygnursegisgadministeringgagdruggtoghelpgdia
gnosegagdisease.gThegoncologygnursegisgadministeringgagdruggtoghelpgtreatgag
disease.gPharmacoeconomicsgincludesganygcostsginvolvedgingdruggtherapy.
Pharmacodynamicsginvolvesghowgagdruggaffectsgthegbodygandgpharmacokinet
icsgisghowgthegbodygactsgongthegbody.
2.
Agphysicianghasgorderedgintramuscularg(IM)ginjectionsgofgmorphine,gagnar
cotic,geveryg4ghoursgasgneededgforgpaingingagmotorgvehiclegaccidentgvictim.g
Thegnursegisgawaregthisgdrugghasgaghighgabusegpotential.gUndergwhatgcategor
ygwouldgmorphinegbegclassified?
,A) SchedulegI
B) SchedulegII
C) SchedulegIII
D) SchedulegIV
Ans: B
Feedback:
NarcoticsgwithgaghighgabusegpotentialgaregclassifiedgasgSchedulegIIgdrugsgbe
causegofgseveregdependencegliability.gSchedulegIgdrugsghaveghighgabusegpot
entialgandgnogacceptedgmedicalguse.gSchedulegIIIgdrugsghavegaglessergabuseg
potentialgthangIIgandgangacceptedgmedicalguse.gSchedulegIVgdrugsghaveglowg
abusegpotentialgandglimitedgdependencegliability.
3.
WhenginvolvedgingphasegIIIgdruggevaluationgstudies,gwhatgresponsibili
tiesgwouldgthegnurseghave?
A) Workinggwithganimalsgwhogareggivengexperimentalg drugs
B) Choosinggappropriategpatientsgtogbeginvolvedgingthegdrugg study
C) Monitoringgandgobservinggpatientsgcloselygforgadverseg effects
D) Conductinggresearchgtogdeterminegeffectivenessgofgtheg drug
Ans: C
Feedback:
PhasegIIIgstudiesginvolvegusegofgagdruggingagvastgclinicalgpopulationgingwhich
gpatientsgaregaskedgtogrecordganygsymptomsgtheygexperiencegwhilegtakinggth
egdrugs.gNursesgmaygbegresponsiblegforghelpinggcollectgandganalyzegtheginfo
rmationgtogbegsharedgwithgthegFoodgandgDruggAdministrationg(FDA)gbutgwo
uldgnotgconductgresearchgindependentlygbecausegnursesgdognotgprescribegme
dications.gUsegofganimalsgingdruggtestinggisgdonegingthegpreclinicalgtrials.gSe
lectgpatientsgwhogareginvolvedgingphasegIIgstudiesgtogparticipategingstudiesgw
heregthegparticipantsghavegthegdiseasegthegdruggisgintendedgtogtreat.gThesegpa
tientsgaregmonitoredgcloselygforgdruggactiongandgadversegeffects.gPhasegIgstu
diesginvolveghealthyghumangvolunteersgwhogaregusuallygpaidgforgtheirgpartici
pation.gNursesgmaygobservegforgadversegeffectsgandgtoxicity.
,4.
Whatgconceptgisgconsideredgwhenggenericgdrugsgaregsubstitutedgforgbr
andgnamegdrugs?
A) Bioavailability
B) Criticalgconcentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailabilitygisgthegportiongofgagdosegofgagdruggthatgreachesgthegsystemicg
circulationgandgisgavailablegtogactgongbodygcells.gBindersgusedgingaggenericg
druggmaygnotgbegthegsamegasgthosegusedgingthegbrandgnamegdrug.gTherefore
,gthegwaygthegbodygbreaksgdowngandgusesgthegdruggmaygdiffer,gwhichgmayg
eliminategaggenericgdruggsubstitution.gCriticalgconcentrationgisgthegamountgo
fgagdruggthatgisgneededgtogcausegagtherapeuticgeffectgandgshouldgnotgdiffergb
etweenggenericgandgbrandgnamegmedications.gDistributiongisgthegphasegofgp
harmacokinetics,gwhichginvolvesgthegmovementgofgagdruggtogthegbodysgtiss
uesgandgisgthegsameginggenericgandgbrandgnamegdrugs.gAgdrugsghalf-
lifegisgthegtimegitgtakesgforgthegamountgofgdruggtogdecreasegtoghalfgthegpeakg
level,gwhichgshouldgnotgchangegwhengsubstitutinggaggenericg medication.
5.
Agnursegisgassessinggthegpatientsghomegmedicationguse.gAfterglisteninggto
gthegpatientglistgcurrentgmedications,gthegnursegasksgwhatgprioritygquestion?
A) Dogyougtakeganyggenericg medications?
B) Areganygofgthesegmedicationsgorphang drugs?
C) Aregthesegmedicationsgsafegtogtakegduringg pregnancy?
D) Dogyougtakeganygover-the-counterg medications?
Ans: D
Feedback:
, Itgisgimportantgforgthegnursegtogspecificallygquestiongusegofgover-the-
countergmedicationsgbecausegpatientsgmaygnotgconsidergthemgimportant.gTh
egpatientgisgunlikelygtogknowgthegmeaninggofgorphangdrugsgunlessgtheygtoog
areghealthgcaregproviders.gSafetygduringgpregnancy,gusegofgaggenericgmedica
tion,gorgclassificationgofgorphangdrugsgaregthingsgthegpatientgwouldgbegunabl
egtoganswergbutgcouldgbegfoundgingreferencegbooksgifgthegnursegwishesgtogre
searchgthem.
6.
Aftergcompletinggagcoursegongpharmacologygforgnurses,gwhatgwillgthegn
ursegknow?
A) Everythinggnecessarygforgsafegandgeffectivegmedicationg administration
B)
Currentgpharmacologicgtherapy;gthegnursegwillgnotgrequireg
ongoinggeducationgforg5gyears.
C)
Generalgdrugginformation;gthegnursegcangconsultgagdruggguidegforg
specificgdrugginformation.
D)
Thegdruggactionsgthatgaregassociatedgwithgeachgclassific
ationgofgmedication
Ans: C
Feedback:
Aftergcompletinggagpharmacologygcoursegnursesgwillghaveggeneralgdrugginfo
rmationgneededgforgsafegandgeffectivegmedicationgadministrationgbutgwillgne
edgtogconsultgagdruggguidegforgspecificgdrugginformationgbeforegadministerin
gganygmedication.gPharmacologygisgconstantlygchanging,gwithgnewgdrugsgen
teringgthegmarketgandgnewgusesgforgexistinggdrugsgidentified.
Continuinggeducationgingpharmacologygisgessentialgtogsafegpractice.gNursesg
tendgtogbecomegfamiliargwithgthegmedicationsgtheygadministergmostgoften,gb
utgtheregwillgalwaysgbegagneedgtogresearchgnewgdrugsgandgalsogthosegthegnur
segisgnotgfamiliargwithgbecausegnognursegknowsgallgmedications.
7.
Agnursegisginstructinggagpregnantgpatientgconcerninggthegpotentialgriskgtog
hergfetusgfromgagPregnancygCategorygBgdrug.gWhatgwouldgthegnurseginform
gthegpatient?
Chapterg1.gIntroduction:gThegNaturegofgDrugsg&gDruggDevelopmentg&gRegulation
1.
Agnursegworkinggingradiologygadministersgiodinegtogagpatientgwhogisghavi
nggagcomputedgtomographyg(CT)gscan.gThegnursegworkinggongthegoncologyg
unitgadministersgchemotherapygtogpatientsgwhoghavegcancer.gAtgthegPublicgH
ealthgDepartment,gagnursegadministersgagmeasles-mumps-
rubellag(MMR)gvaccinegtogag14-month-
oldgchildgasgagroutinegimmunization.gWhichgbranchgofgpharmacologygbestgde
scribesgthegactionsgofgallgthreeg nurses?
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacologygisgthegstudygofgthegbiologicgeffectsgofgchemicals.gNursesgaregi
nvolvedgwithgclinicalgpharmacologygorgpharmacotherapeutics,gwhichgisgagbr
anchgofgpharmacologygthatgdealsgwithgthegusesgofgdrugsgtogtreat,gprevent,gan
dgdiagnosegdisease.gThegradiologygnursegisgadministeringgagdruggtoghelpgdia
gnosegagdisease.gThegoncologygnursegisgadministeringgagdruggtoghelpgtreatgag
disease.gPharmacoeconomicsgincludesganygcostsginvolvedgingdruggtherapy.
Pharmacodynamicsginvolvesghowgagdruggaffectsgthegbodygandgpharmacokinet
icsgisghowgthegbodygactsgongthegbody.
2.
Agphysicianghasgorderedgintramuscularg(IM)ginjectionsgofgmorphine,gagnar
cotic,geveryg4ghoursgasgneededgforgpaingingagmotorgvehiclegaccidentgvictim.g
Thegnursegisgawaregthisgdrugghasgaghighgabusegpotential.gUndergwhatgcategor
ygwouldgmorphinegbegclassified?
,A) SchedulegI
B) SchedulegII
C) SchedulegIII
D) SchedulegIV
Ans: B
Feedback:
NarcoticsgwithgaghighgabusegpotentialgaregclassifiedgasgSchedulegIIgdrugsgbe
causegofgseveregdependencegliability.gSchedulegIgdrugsghaveghighgabusegpot
entialgandgnogacceptedgmedicalguse.gSchedulegIIIgdrugsghavegaglessergabuseg
potentialgthangIIgandgangacceptedgmedicalguse.gSchedulegIVgdrugsghaveglowg
abusegpotentialgandglimitedgdependencegliability.
3.
WhenginvolvedgingphasegIIIgdruggevaluationgstudies,gwhatgresponsibili
tiesgwouldgthegnurseghave?
A) Workinggwithganimalsgwhogareggivengexperimentalg drugs
B) Choosinggappropriategpatientsgtogbeginvolvedgingthegdrugg study
C) Monitoringgandgobservinggpatientsgcloselygforgadverseg effects
D) Conductinggresearchgtogdeterminegeffectivenessgofgtheg drug
Ans: C
Feedback:
PhasegIIIgstudiesginvolvegusegofgagdruggingagvastgclinicalgpopulationgingwhich
gpatientsgaregaskedgtogrecordganygsymptomsgtheygexperiencegwhilegtakinggth
egdrugs.gNursesgmaygbegresponsiblegforghelpinggcollectgandganalyzegtheginfo
rmationgtogbegsharedgwithgthegFoodgandgDruggAdministrationg(FDA)gbutgwo
uldgnotgconductgresearchgindependentlygbecausegnursesgdognotgprescribegme
dications.gUsegofganimalsgingdruggtestinggisgdonegingthegpreclinicalgtrials.gSe
lectgpatientsgwhogareginvolvedgingphasegIIgstudiesgtogparticipategingstudiesgw
heregthegparticipantsghavegthegdiseasegthegdruggisgintendedgtogtreat.gThesegpa
tientsgaregmonitoredgcloselygforgdruggactiongandgadversegeffects.gPhasegIgstu
diesginvolveghealthyghumangvolunteersgwhogaregusuallygpaidgforgtheirgpartici
pation.gNursesgmaygobservegforgadversegeffectsgandgtoxicity.
,4.
Whatgconceptgisgconsideredgwhenggenericgdrugsgaregsubstitutedgforgbr
andgnamegdrugs?
A) Bioavailability
B) Criticalgconcentration
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailabilitygisgthegportiongofgagdosegofgagdruggthatgreachesgthegsystemicg
circulationgandgisgavailablegtogactgongbodygcells.gBindersgusedgingaggenericg
druggmaygnotgbegthegsamegasgthosegusedgingthegbrandgnamegdrug.gTherefore
,gthegwaygthegbodygbreaksgdowngandgusesgthegdruggmaygdiffer,gwhichgmayg
eliminategaggenericgdruggsubstitution.gCriticalgconcentrationgisgthegamountgo
fgagdruggthatgisgneededgtogcausegagtherapeuticgeffectgandgshouldgnotgdiffergb
etweenggenericgandgbrandgnamegmedications.gDistributiongisgthegphasegofgp
harmacokinetics,gwhichginvolvesgthegmovementgofgagdruggtogthegbodysgtiss
uesgandgisgthegsameginggenericgandgbrandgnamegdrugs.gAgdrugsghalf-
lifegisgthegtimegitgtakesgforgthegamountgofgdruggtogdecreasegtoghalfgthegpeakg
level,gwhichgshouldgnotgchangegwhengsubstitutinggaggenericg medication.
5.
Agnursegisgassessinggthegpatientsghomegmedicationguse.gAfterglisteninggto
gthegpatientglistgcurrentgmedications,gthegnursegasksgwhatgprioritygquestion?
A) Dogyougtakeganyggenericg medications?
B) Areganygofgthesegmedicationsgorphang drugs?
C) Aregthesegmedicationsgsafegtogtakegduringg pregnancy?
D) Dogyougtakeganygover-the-counterg medications?
Ans: D
Feedback:
, Itgisgimportantgforgthegnursegtogspecificallygquestiongusegofgover-the-
countergmedicationsgbecausegpatientsgmaygnotgconsidergthemgimportant.gTh
egpatientgisgunlikelygtogknowgthegmeaninggofgorphangdrugsgunlessgtheygtoog
areghealthgcaregproviders.gSafetygduringgpregnancy,gusegofgaggenericgmedica
tion,gorgclassificationgofgorphangdrugsgaregthingsgthegpatientgwouldgbegunabl
egtoganswergbutgcouldgbegfoundgingreferencegbooksgifgthegnursegwishesgtogre
searchgthem.
6.
Aftergcompletinggagcoursegongpharmacologygforgnurses,gwhatgwillgthegn
ursegknow?
A) Everythinggnecessarygforgsafegandgeffectivegmedicationg administration
B)
Currentgpharmacologicgtherapy;gthegnursegwillgnotgrequireg
ongoinggeducationgforg5gyears.
C)
Generalgdrugginformation;gthegnursegcangconsultgagdruggguidegforg
specificgdrugginformation.
D)
Thegdruggactionsgthatgaregassociatedgwithgeachgclassific
ationgofgmedication
Ans: C
Feedback:
Aftergcompletinggagpharmacologygcoursegnursesgwillghaveggeneralgdrugginfo
rmationgneededgforgsafegandgeffectivegmedicationgadministrationgbutgwillgne
edgtogconsultgagdruggguidegforgspecificgdrugginformationgbeforegadministerin
gganygmedication.gPharmacologygisgconstantlygchanging,gwithgnewgdrugsgen
teringgthegmarketgandgnewgusesgforgexistinggdrugsgidentified.
Continuinggeducationgingpharmacologygisgessentialgtogsafegpractice.gNursesg
tendgtogbecomegfamiliargwithgthegmedicationsgtheygadministergmostgoften,gb
utgtheregwillgalwaysgbegagneedgtogresearchgnewgdrugsgandgalsogthosegthegnur
segisgnotgfamiliargwithgbecausegnognursegknowsgallgmedications.
7.
Agnursegisginstructinggagpregnantgpatientgconcerninggthegpotentialgriskgtog
hergfetusgfromgagPregnancygCategorygBgdrug.gWhatgwouldgthegnurseginform
gthegpatient?
