what is hemostasis? - Answers process of forming fibrin clots in the wall of damaged blood vessels and
preventing blood loss
hypercoagulation and excessive throbi/emboli formation can lead to what? - Answers impaired
circulatory problems -->thromboembolism
stroke
MI
impaired circulatory problems from excessive blood loss can lead to what? - Answers shock
Low BP
Low tissue gas exchange
low nutrient delivery and waste removal
acid-base dis balance
what is primary hemostasis? - Answers includes vasoconstriction and platelet plug formation
is fast but temporary
what is secondary hemostasis? - Answers blood clot formation (coagulation)
in general what are the 5 steps in the bodies response to tissue damage? - Answers tissue damage
(trauma)
bleeding
, Hemostasis (fibrin clot)
Clot dissolution
tissue repair and regeneration
how long can the vascular spasm last in response to tissue damage? - Answers max of 30 minutes
vascular spasms in hemostasis are triggered by what? - Answers direct injury to vascular smooth muscle
chemicals released by endothelial cells (TxA2, ET1) and platelets (serotonin, TxA2)
how is the vascular spasm maintained and where is it most effective? - Answers maintained by pain
most effective in small vessels and as the amount of tissue damage increases
platelet plug formatin is initiated by exposure of blood to what? - Answers damaged endothelium
underlying collagen
damaged endothelium does not produce what? - Answers protective factors NO and PG2
the intact endothelium produces _____________ in response to substances released from the
______________, what are they called? - Answers produces vasodilators
released from the platelets
are called Vasodilators or Endothelium-Derived-Relaxing Factors (EDRF)
what are the 4 steps in the platelet plug formation? - Answers 1)tethering and rolling of platelets
2)Adhesion of platelets by:
Collagen