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Systemic pathology handwritten

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Systemic pathology, as covered in Paper 2 and based on Robbins, focuses on diseases affecting specific organ systems. It includes cardiovascular conditions like atherosclerosis, myocardial infarction, and rheumatic heart disease, highlighting pathogenesis and morphological changes. Respiratory diseases such as pneumonia, tuberculosis, and COPD are discussed with emphasis on patterns of inflammation and structural damage. In the gastrointestinal system, peptic ulcer disease and inflammatory bowel diseases like ulcerative colitis are key topics, detailing their causes, pathology, and complications. Each system is approached through gross and microscopic pathology to understand disease progression and clinical relevance.

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THY ROID
follimarcels
Thy void horow
Anatomy -



7 2 lobea mus




Para
follicularthyroid
ea

Synthesis of thyroid hormones PTM
Iodine
absorption >
- thyroid peroxidase I
In (diet) +
Intral
Oxidation
ofIodine
Ciodide) (converts Iodide Fodination
to Iodine) Indive +
tyrosine
L
Released when needed ↓
↑ mono-Podotyrosine (MIT -



thyroid binding globulin di
iodotyrosine (DIT-


fl Thyroidd

follides ,
MIT+ DIT
Peroxidase


3-festating
+




Ty-slow Acting




Negative feedback
↓ in >
-



Hypol pit
↓ ↑ TSH

Tsiy

<
-
↑ TRHYTSH J +


prolactin

, Disorders (Hyperthyroidism Hypothalamus pituitary
Axis .


Hypothalances


TRA

↳ Ant
petultary

st

thysoid
cells
more in blood

Hypothyroidism
Negative Signal
⑮ Th





causing LTsHa Tot




TSH TRH &L
TgT4
less in
blood

causes
&TSHTRM
9




- Colloid

G
-
para follicular cells

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Uploaded on
May 8, 2025
Number of pages
12
Written in
2024/2025
Type
Class notes
Professor(s)
Patho
Contains
All classes

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