PMC II EXAM II LIPID-LOWERING AGENTS ESPOSITO
Which drugs works on A - Answers :statin
which drug works on B - Answers :fibrate
which drug works on C - Answers :niacin
which drug works on D - Answers :bile acids
which drug works on E - Answers :Cholesterol absorption blockers
Vytorin is made of - Answers :statin and ezetimibe
simcor is made of - Answers :simvastatin and niacin
MOA of statins - Answers :inhibit cholesterol precursor mevalonic acid
MOA of fibrates - Answers :PPAR-alpha agonist which increases lipoprotein lipase
synthesis and increases TG clearance
MOA of bile acid sequestrants - Answers :block intestinal absorptions
MOA of cholesterol absorption inhibitors - Answers :block the reabsorption of
cholesterol in the brush border of the small intestine
MOA of niacin - Answers :descreases hepatic VLDL, inhibits lipolysis
ADE of niacin - Answers :flushing
ADE of fibrates and statins - Answers :rhabdomyolysis
Used in digitalis toxicity - Answers :bile acid sequestrants
ADE of fish oil - Answers :weight gain
ADE of statins - Answers :grapefruit juice alters metabolism
Avoid in patients with renal or hepatic dysfunction - Answers :Fibrates
ADE of Bile Acid Sequestrants - Answers :constipation
What lipoprotein originates from the intestines? - Answers :chylomicrons
MOA of garlic - Answers :formation of sulfide bridges, by the disulfides, with HMG-CoA
reductase which in turn inhibit enzyme
Which drugs works on A - Answers :statin
which drug works on B - Answers :fibrate
which drug works on C - Answers :niacin
which drug works on D - Answers :bile acids
which drug works on E - Answers :Cholesterol absorption blockers
Vytorin is made of - Answers :statin and ezetimibe
simcor is made of - Answers :simvastatin and niacin
MOA of statins - Answers :inhibit cholesterol precursor mevalonic acid
MOA of fibrates - Answers :PPAR-alpha agonist which increases lipoprotein lipase
synthesis and increases TG clearance
MOA of bile acid sequestrants - Answers :block intestinal absorptions
MOA of cholesterol absorption inhibitors - Answers :block the reabsorption of
cholesterol in the brush border of the small intestine
MOA of niacin - Answers :descreases hepatic VLDL, inhibits lipolysis
ADE of niacin - Answers :flushing
ADE of fibrates and statins - Answers :rhabdomyolysis
Used in digitalis toxicity - Answers :bile acid sequestrants
ADE of fish oil - Answers :weight gain
ADE of statins - Answers :grapefruit juice alters metabolism
Avoid in patients with renal or hepatic dysfunction - Answers :Fibrates
ADE of Bile Acid Sequestrants - Answers :constipation
What lipoprotein originates from the intestines? - Answers :chylomicrons
MOA of garlic - Answers :formation of sulfide bridges, by the disulfides, with HMG-CoA
reductase which in turn inhibit enzyme
