PMC III EXAM 2 DR. ESPOSITO ANTIVIRALS PART 3

PMC III EXAM 2: DR. ESPOSITO ANTIVIRALS PART 3
What are the drugs that are independent of viral enzymes - Answers :-Docosanol
(Abreva)
-Trifluridine (Trifluorothymidine)
-Foscarnet
-Cidofovir
-Letermovir

What is the MOA of Docosanol - Answers :-prevents HSV1 viral envelope fusion

What are the uses of Docosanol - Answers :-reduces healing time for orolabial herpes
by ~18h
-use within the first 12h of symptom onset

What are the uses of Trifluridine - Answers :-HSV1
-HSV2
-CMV

What is the MOA of trifluridine - Answers :inhibits the incorporation of thymidine
triphosphate into viral DNA, creates defective DNA strand

What is Trifluridine phosphorylated by - Answers :host enzymes (not viral thymidine
kinase like the others)

Trifluridine is used for: - Answers :-topical treatment of epithelial keratitis cause by HSV

What is Foscarnet used for - Answers :-HSV
-VZV (HHV3)
-CMV retinitis

What is the MOA of Foscarnet - Answers :inhibits viral DNA/RNA polymerase and HIV
reverse transcriptase without requiring activation by phosphorylation

When is Foscarnet avoided - Answers :-avoid taking it with drugs that have nephrotoxic
potential

-Foscarnet causes renal toxicity (Ca/K/Mg/PO)

What in combination with Ganciclovir has a synergistic effect against CMV - Answers
:foscarnet

Why isnt Foscarnet used orally - Answers :deposits in bone

What is Cidofovir (IV) used for - Answers :-HSV
-VZV (HHV3)