APHON Principles of Chemo and Biotherapy Exam Questions And Answers Verified 100% Correct

APHON Principles of Chemo and Biotherapy Exam Questions And Answers Verified 100% Correct What chemo classification provide an anti cancer effect and not clearly understood? - ANSWER Biological response modifiers Which agents are Cell Cycle Specific? - ANSWER Antimetabolites, plant alkaloids, and misc agents such as asparaginase and dacarbazine. Which agents are cell cycle nonspecific? - ANSWER Alkylating agents, nitrosureas, antitumor antibiotics, hormones, steroids, and misc agents such as procarbazine What are common pediatric chemo alkylating agents? - ANSWER Cyclophosphamide, ifosfamide, temozolomide, dacarbazine, procarbazine, carboplatin, cisplatin What are common pediatric chemo plant alkaloids? - ANSWER Vincristine, vinblastine, etoposide, irinotecan, topotecan, paclitaxel What are common side effects of plant alkaloids? - ANSWER Peripheral neuropathies, constipation, N&V, diarrhea, amenorrhea, and infertility Which types of agents are associated with secondary malignancies? - ANSWER Alkylating agents, plant alkaloids What are common side effects of alkylating agents? - ANSWER N&V, bone marrow suppression, reproductive disabilities What are common side effects of antitumor antibiotics? - ANSWER Bone marrow suppression, mucositis, N&V, cardiac toxicity, reproductive disabilities Which antitumor antibiotic is cell cycle specific? - ANSWER Bleomycin-it works in both G2 and M phase What are the major side effects of antimetabolites? - ANSWER Bone marrow suppression, N&V, mucositis, liver injury What pediatric chemo drugs are antimetabolite agents? - ANSWER Methotrexate, fluorouracil (5- FU), cytarabine (Ara-C), Mercaptopurine (6-MP), thioguanine (6-TG), hydroxyurea Which antimetabolite is associated with hepatoportal sclerosis and esophageal varices? - ANSWER Thioguanine Which chemotherapy agents are hormonal agents? - ANSWER Corticosteroids How do corticosteroids fight cancers? - ANSWER By lysing lymphoblasts, decreasing cerebral edema associated with brain tumors, and help with antiemetic control MDR1 - ANSWER Multidrug resistance gene 1. May occur prior to exposure of chemo or after. Caused by the presence of P-glycoprotein Biotherapy - ANSWER Targeted anticancer agents also known as biological response modifiers (BRM) Tyrosine kinase inhibitors (TKIs) are what class - ANSWER Biotherapy Monoclonal antibodies (MoAbs) are what class - ANSWER Biotherapy Define pharmacokinetics - ANSWER Study of drug absorption, metabolism, and excretion Define pharmacodynamics - ANSWER The concentration of the drug in the body and how it produces a response Define adjuvant chemotherapy - ANSWER The use of chemo after another type of therapy, such as surgery, to treat residual disease or undetectable metastasis. How should chemo be administered to maximize effectiveness? - ANSWER At the maximum tolerated doses with the shortest possible interval