Wilkes NSG 533 Exam 2 Study Guide Advanced Pharmacology, 100% Verified.

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EXAM 2 STUDY GUIDE

Advanced Pharmacology - Wilkes




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NSG 533 Exam 2 Study Guide

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,1. genetics:
study of inherited traits and their variation (individual)


2. genome:
total genetic composition of an organism or species (group)



3. genomics:
molecular analysis of the entire genome of a species


4. gene:
basic unit of heredity



5. list the four types of mendelian inheritance:
1. autosomal dominant
2. autosomal recessive
3. X-linked dominant
4. X-linked recessive


6. autosomal dominant:
- phenotype is expressed in those who have 1 copy of a gene mutation


- mothers and fathers are equally likely to transmit or inherit the disorder


- seen in multiple generations



, 7. autosomal recessive:
- requires presence of 2 copies of a gene mutation in order to express phenotype


- usually seen in a single generation


- mothers/fathers equally likely to transmit or inherit disorder



8. X-linked dominant:
- dominant disorder caused by a mutation in a gene on the X chromosome


- heterozygous female (XAXa) and hemizygous male (XAY)


- affected males have more severe phenotype



9. X-Linked Recessive:
mutation on gene in X chromosome causes phenotype to be expressed in
hemizygous males (XaY) and homozygous females (XaXa)


10. types of X-linked recessive disorders:

1. duchene muscular dystrophy
2. hemophilia
3. color blindness